UniProt Q06124
Tyrosine-protein phosphatase non-receptor type 11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (UniProt Q06124), EC 3.1.3.48: 116 experimental structures on GenesisL1, 30 ligands bound, 81 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q06124
- Protein
- Tyrosine-protein phosphatase non-receptor type 11
- EC
- 3.1.3.48
- Experimental structures
- 116
- Predicted models
- 0
- Ligands
- 30
- Pockets
- 81 · 6 records with a druggable one
Structures
116 records of Q06124 in the MolNFT archive: 116 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2SHP | Tyrosine phosphatase shp-2 | x-ray diffraction | A, B | — | — |
| 2SHP | Tyrosine phosphatase shp-2 | x-ray diffraction | A, B | — | — |
| 3B7O | Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site | x-ray diffraction | A | — | — |
| 3B7O | Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site | x-ray diffraction | A | — | — |
| 3MOW | Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1 | x-ray diffraction | A | — | — |
| 3MOW | Crystal structure of SHP2 in complex with a tautomycetin analog ttn D- 1 | x-ray diffraction | A | — | — |
| 3O5X | Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based… | x-ray diffraction | A | — | — |
| 3O5X | Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based… | x-ray diffraction | A | — | — |
| 3TKZ | Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide | x-ray diffraction | A | — | — |
| 3TKZ | Structure of the shp-2 N-SH2 domain in a 1:2 complex with rvipyfvplnr peptide | x-ray diffraction | A | — | — |
| 3TL0 | Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide | x-ray diffraction | A | — | — |
| 3TL0 | Structure of SHP2 N-SH2 domain in complex with rlnpyaqlwhr peptide | x-ray diffraction | A | — | — |
| 3ZM0 | Catalytic domain of human SHP2 | x-ray diffraction | A | — | — |
| 3ZM0 | Catalytic domain of human SHP2 | x-ray diffraction | A | — | — |
| 3ZM1 | Catalytic domain of human SHP2 | x-ray diffraction | A | — | — |
| 3ZM1 | Catalytic domain of human SHP2 | x-ray diffraction | A | — | — |
| 3ZM2 | Catalytic domain of human SHP2 | x-ray diffraction | A | — | — |
| 3ZM2 | Catalytic domain of human SHP2 | x-ray diffraction | A | — | — |
| 3ZM3 | Catalytic domain of human SHP2 | x-ray diffraction | A | — | — |
| 3ZM3 | Catalytic domain of human SHP2 | x-ray diffraction | A | — | — |
| 4DGP | The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) | x-ray diffraction | A | — | — |
| 4DGP | The wild-type src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) | x-ray diffraction | A | — | — |
| 4DGX | LEOPARD Syndrome-Associated SHP2/Y279C mutant | x-ray diffraction | A | — | — |
| 4DGX | Leopard syndrome-associated SHP2/Y279C mutant | x-ray diffraction | A | — | — |
| 4GWF | Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation | x-ray diffraction | A, B | — | — |
| 4GWF | Crystal structure of the tyrosine phosphatase shp-2 with Y279C mutation | x-ray diffraction | A, B | — | — |
| 4H1O | Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation | x-ray diffraction | A | — | — |
| 4H1O | Crystal structure of the tyrosine phosphatase shp-2 with D61G mutation | x-ray diffraction | A | — | — |
| 4H34 | Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation | x-ray diffraction | A | — | — |
| 4H34 | Crystal structure of the tyrosine phosphatase shp-2 with Q506P mutation | x-ray diffraction | A | — | — |
| 4JE4 | Crystal Structure of Monobody NSa1/SHP2 N-SH2 Domain Complex | x-ray diffraction | A | — | — |
| 4JE4 | Crystal structure of monobody NSA1/SHP2 N-SH2 domain complex | x-ray diffraction | A | — | — |
| 4JEG | Crystal Structure of Monobody CS1/SHP2 C-SH2 Domain Complex | x-ray diffraction | A | — | — |
| 4JEG | Crystal structure of monobody CS1/SHP2 C-SH2 domain complex | x-ray diffraction | A | — | — |
| 4JMG | Crystal structure of the synthetic protein in complex with pY peptide | x-ray diffraction | B | — | — |
| 4JMG | Crystal structure of the synthetic protein in complex with py peptide | x-ray diffraction | B | — | — |
| 4NWF | Crystal structure of the tyrosine phosphatase SHP-2 with N308D mutation | x-ray diffraction | A, B | — | — |
| 4NWF | Crystal structure of the tyrosine phosphatase shp-2 with N308D mutation | x-ray diffraction | A, B | — | — |
| 4NWG | Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation | x-ray diffraction | A, B | — | — |
| 4NWG | Crystal structure of the tyrosine phosphatase shp-2 with E139D mutation | x-ray diffraction | A, B | — | — |
| 4OHD | LEOPARD Syndrome-Associated SHP2/A461T mutant | x-ray diffraction | A | — | — |
| 4OHD | Leopard syndrome-associated SHP2/A461T mutant | x-ray diffraction | A | — | — |
| 4OHE | LEOPARD Syndrome-Associated SHP2/G464A mutant | x-ray diffraction | A | — | — |
| 4OHE | Leopard syndrome-associated SHP2/G464A mutant | x-ray diffraction | A | — | — |
| 4OHH | LEOPARD Syndrome-Associated SHP2/Q506P mutant | x-ray diffraction | A | — | — |
| 4OHH | Leopard syndrome-associated SHP2/Q506P mutant | x-ray diffraction | A | — | — |
| 4OHI | LEOPARD Syndrome-Associated SHP2/Q510E mutant | x-ray diffraction | A | — | — |
| 4OHI | Leopard syndrome-associated SHP2/Q510E mutant | x-ray diffraction | A | — | — |
| 4OHL | LEOPARD Syndrome-Associated SHP2/T468M mutant | x-ray diffraction | A, B | — | — |
| 4OHL | Leopard syndrome-associated SHP2/T468M mutant | x-ray diffraction | A, B | — | — |
| 4PVG | Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small… | x-ray diffraction | A | — | — |
| 4PVG | Crystal structure of protein tyrosine phosphatase SHP2 catalytic domain complex with small… | x-ray diffraction | A | — | — |
| 4QSY | SHP2 SH2 domain in complex with GAB1 peptide | x-ray diffraction | A | — | — |
| 4QSY | SHP2 SH2 domain in complex with GAB1 peptide | x-ray diffraction | A | — | — |
| 4RDD | Co-crystal structure of SHP2 in complex with a Cefsulodin derivative | x-ray diffraction | A | — | — |
| 4RDD | Co-crystal structure of SHP2 in complex with a cefsulodin derivative | x-ray diffraction | A | — | — |
| 5BK8 | Cancer-associated SHP2/T507K mutant | x-ray diffraction | A | — | — |
| 5BK8 | Cancer-associated SHP2/T507K mutant | x-ray diffraction | A | — | — |
| 5DF6 | Crystal structure of PTPN11 tandem SH2 domains in complex with a txnip peptide | x-ray diffraction | A | — | — |
| 5EHP | Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP836 | x-ray diffraction | A, B | 5OA, PO4 | — |
56 records more on the page itself.
Ligands
- PO4 · Phosphate ion · in 18 records
- 5OD · 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine · in 7 records
- DZS · 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2, 4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid · in 3 records
- 3CW · [3-(4-amino-4-methylpiperidin-1-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl]methanol · in 2 records
- 8J6 · 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine · in 2 records
- DYV · 1-(3-chloro-4-{[1-(2-hydroxy-3-methoxyphenyl)-5-oxo[1, 2,4]triazolo[4,3-a]quinazolin-4(5H)-yl]methyl}benzene-1-carbonyl)-L-proline · in 2 records
- DZV · 4-[(2-chlorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one · in 2 records
- JEA · 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclopropylamino)pyridin-4-yl]-5-methyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one · in 2 records
- 33I · 6-(4-amino-4-methylpiperidin-1-yl)-3-(3-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one · in 1 record
- 37I · 4-[6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl]-3-chloro-N-methylpyridin-2-amine · in 1 record
- 3ED · 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3H)-one · in 1 record
- 4Q4 · {3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl}methanol · in 1 record
- 5OA · 5-[2,3-bis(chloranyl)phenyl]-2-[(3~{R},5~{S})-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine · in 1 record
- 83Q · 6-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-3-[2,3-bis(chloranyl)phenyl]sulfanyl-pyrazin-2-amine · in 1 record
- A1H4H · (1R,5S)-8-[7-(4-chloranyl-2-methyl-indazol-5-yl)-5H-pyrrolo[2,3-b]pyrazin-3-yl]-8-azabicyclo[3.2.1]octan-3-amine · in 1 record
- A1H4I · N-(1H-indol-7-yl)methanesulfonamide · in 1 record
- A1H4N · 3,5-bis(chloranyl)pyrazin-2-amine · in 1 record
- A1H4Q · 5-(aminomethyl)-N-(3-chloranyl-1-methyl-indol-7-yl)-1,3-dihydroisoindole-2-sulfonamide · in 1 record
- A1H4T · (1S,5R)-8-[3-[2,3-bis(chloranyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-6-yl]-8-azabicyclo[3.2.1]octan-3-amine · in 1 record
- CL · Chloride ion · in 1 record
- DZJ · 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-B][1, 3]benzothiazol-4-one · in 1 record
- JE1 · 2-[4-(aminomethyl)-4-methylpiperidin-1-yl]-5-{[2-(trifluoromethyl)pyridin-3-yl]sulfanyl}pyrimidin-4(3H)-one · in 1 record
- JE4 · 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)-5-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one · in 1 record
- JE7 · 5-[(2,3-dichlorophenyl)sulfanyl]-3H-imidazo[4,5-b]pyridin-2-amine · in 1 record
- JED · 3-(4-bromophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid · in 1 record
- JEJ · 3-(2-chlorophenyl)-6-{4-[(dimethylamino)methyl]phenyl}-5-methyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one · in 1 record
- SO4 · Sulfate ion · in 1 record
- U9Y · 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine · in 1 record
- VKP · 6-(4-amino-4-methylpiperidin-1-yl)-3-[(2,3-dichlorophenyl)sulfanyl]pyrazin-2-amine · in 1 record
- VKS · (3S,4S)-8-{6-amino-5-[(2-amino-3-chloropyridin-4-yl) sulfanyl]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine · in 1 record
Elsewhere
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