5OD · 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine

Binding sites

5OD in 7 structures; the first of them:

• 6BMW · Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors… · 5OD A601 · binds THR108, GLU110, ARG111, PHE113, HIS114, THR218, THR219, GLU249 and 8 more
• 6BMU · Non-receptor protein tyrosine phosphatase SHP2 in complex with allosteric inhibitors… · 5OD A601 · binds THR108, GLU110, ARG111, PHE113, HIS114, THR218, THR219, GLU249 and 7 more
• 6BMW · Non-receptor protein tyrosine phosphatase SHP2 in complex with allosteric inhibitors… · 5OD A601 · binds THR108, GLU110, ARG111, PHE113, HIS114, THR218, THR219, GLU249 and 7 more
• 6BMY · Non-receptor protein tyrosine phosphatase SHP2 in complex with allosteric inhibitors… · 5OD A601 · binds THR108, GLU110, ARG111, PHE113, HIS114, THR218, THR219, GLU249 and 7 more
• 6CMR · Closed structure of active SHP2 mutant E76D bound to SHP099 inhibitor · 5OD A601 · binds THR108, GLU110, ARG111, PHE113, HIS114, THR218, THR219, GLU249 and 7 more
• 6CMS · Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor · 5OD A601 · binds THR108, GLU110, ARG111, PHE113, HIS114, THR218, THR219, GLU249 and 7 more
• 6CRG · Crystal structure of SHP2 E76K gof mutant in complex with SHP099 · 5OD A601 · binds THR108, GLU110, ARG111, PHE113, HIS114, THR218, THR219, GLU249 and 8 more

Residues it binds most

THR 12, GLU 12, GLN 12, ARG 12, HIS 12, LEU 12, LYS 12, PHE 12, PRO 12, ASP 3 (residue and the binding sites it lines).

Found with

• GOL · Glycerol
• PO4 · Phosphate ion
• DZS · 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2, 4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid
• DYV · 1-(3-chloro-4-{[1-(2-hydroxy-3-methoxyphenyl)-5-oxo[1, 2,4]triazolo[4,3-a]quinazolin-4(5H)-yl]methyl}benzene-1-carbonyl)-L-proline
• DZV · 4-[(2-chlorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
• SO4 · Sulfate ion