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Ligand · DZS

DZS · 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2, 4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid

DZS, 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2, 4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid (C23 H15 Cl N4 O4, 446.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding…

Component
DZS
Formula
C23 H15 Cl N4 O4
Class
ligand
Structures
2
PDB entries
2

Binding sites

DZS in 2 structures; the first of them:

  • 6BMV · Non-receptor protein tyrosine phosphatase SHP2 in complex with allosteric inhibitor SHP504 · DZS A601 · binds GLN79, TYR80, GLU83, HIS84, LEU262, TYR263, SER264, ARG265 and 4 more
  • 6BMW · Non-receptor protein tyrosine phosphatase SHP2 in complex with allosteric inhibitors… · DZS A602 · binds GLN79, TYR80, GLU83, HIS84, LEU262, TYR263, SER264, ARG265 and 4 more

Residues it binds most

GLN 4, LEU 4, TYR 4, ARG 4, ASN 4, GLU 4, HIS 4, LYS 4, SER 4 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion
  • 5OD · 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine
  • GOL · Glycerol

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