UniProt Q02372
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Q02372)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (UniProt Q02372): 44 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 113 pockets. Binding sites, druggability and experiment…
- UniProt
- Q02372
- Protein
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
- Experimental structures
- 44
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 113 · 33 records with a druggable one
Structures
45 records of Q02372 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7DGQ | Activity optimized supercomplex state1 | electron microscopy | e | — | 1 (best 0.84) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | e | — | 1 (best 0.84) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | e | — | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | e | — | 1 (best 0.84) |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | e | — | — |
| 7DKF | Activity optimized supercomplex state4 | electron microscopy | e2 | — | 1 (best 0.84) |
| 7QSD | Bovine complex I in the active state at 3.1 A | electron microscopy | l | 3PE | 4 (best 0.84) |
| 7QSD | Bovine complex I in the active state at 3.1 a | electron microscopy | l | 3PE | — |
| 7QSK | Bovine complex I in lipid nanodisc, Active-Q10 | electron microscopy | l | 3PE, MYR | 3 (best 0.86) |
| 7QSK | Bovine complex I in lipid nanodisc, active-Q10 | electron microscopy | l | 3PE, MYR | — |
| 7QSL | Bovine complex I in lipid nanodisc, active-apo | electron microscopy | l | 3PE, MYR | — |
| 7QSM | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | electron microscopy | l | 3PE, MYR | 4 (best 0.85) |
| 7QSM | Bovine complex I in lipid nanodisc, deactive-ligand (composite) | electron microscopy | l | 3PE, MYR | — |
| 7QSN | Bovine complex I in lipid nanodisc, Deactive-apo | electron microscopy | l | 3PE, MYR | 4 (best 0.87) |
| 7QSN | Bovine complex I in lipid nanodisc, deactive-apo | electron microscopy | l | 3PE, MYR | — |
| 7QSO | Bovine complex I in lipid nanodisc, State 3 (Slack) | electron microscopy | l | 3PE | — |
| 7QSO | Bovine complex I in lipid nanodisc, state 3 (slack) | electron microscopy | l | 3PE | — |
| 7R41 | Bovine complex I in the presence of IM1761092, active class i (Composite map) | electron microscopy | l | 3PE, MYR | 4 (best 0.85) |
| 7R42 | Bovine complex I in the presence of IM1761092, active class ii (Composite map) | electron microscopy | l | 3PE, MYR | 3 (best 0.87) |
| 7R43 | Bovine complex I in the presence of IM1761092, active class iii (Composite map) | electron microscopy | l | 3PE, MYR | — |
| 7R44 | Bovine complex I in the presence of IM1761092, active class iv (Composite map) | electron microscopy | l | 3PE, MYR | 3 (best 0.86) |
| 7R45 | Bovine complex I in the presence of IM1761092, deactive class i (Composite map) | electron microscopy | l | 3PE, MYR | 4 (best 0.86) |
| 7R46 | Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) | electron microscopy | l | 3PE, MYR | 3 (best 0.87) |
| 7R47 | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | electron microscopy | l | 3PE, MYR | — |
| 7R48 | Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) | electron microscopy | l | 3PE, MYR | 4 (best 0.85) |
| 7R4C | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | electron microscopy | l | 3PE, MYR | 5 (best 0.85) |
| 7R4D | Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) | electron microscopy | l | 3PE, MYR | 4 (best 0.85) |
| 7R4F | Bovine complex I in the presence of IM1761092, slack class i (Composite map) | electron microscopy | l | 3PE, MYR | 3 (best 0.88) |
| 7R4G | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | electron microscopy | l | 3PE, MYR | 4 (best 0.85) |
| 8Q0A | Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | l | PC1, 3PE, MYR | 4 (best 0.87) |
| 8Q0F | Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | l | PC1, 3PE, MYR | 4 (best 0.87) |
| 8Q0J | Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. | electron microscopy | l | — | 4 (best 0.86) |
| 8Q0M | Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | l | PC1, PLC, 3PE, MYR | 4 (best 0.86) |
| 8Q0O | Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | l | PC1, PLC, 3PE, MYR | 3 (best 0.88) |
| 8Q0Q | Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM | electron microscopy | l | — | 3 (best 0.85) |
| 8Q1P | Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially… | electron microscopy | l | PC1, 3PE, MYR | 4 (best 0.87) |
| 8Q1U | Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially… | electron microscopy | l | PC1, 3PE, MYR | 5 (best 0.86) |
| 8Q1Y | Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially… | electron microscopy | l | PC1, 3PE, MYR | 3 (best 0.88) |
| 8Q25 | Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially… | electron microscopy | l | PC1, 3PE, MYR | 3 (best 0.88) |
| 8Q46 | Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | l | PC1, 3PE, MYR | 4 (best 0.86) |
| 8Q47 | Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. | electron microscopy | l | PC1, 3PE, MYR | 3 (best 0.88) |
| 8Q48 | Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. | electron microscopy | l | PLC, PC1, 3PE, MYR | 4 (best 0.87) |
| 8Q49 | Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | l | PC1, 3PE, MYR | 3 (best 0.88) |
| 8Q4A | Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | l | PC1, 3PE, MYR | 4 (best 0.87) |
| Q02372 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8… | predicted | A | — | 2 (best 0.32) |
Ligands
Experiment against prediction
- 7R4C chain l against the predicted model Q02372: TM-score 0.98, RMSD 0.75 Å
- 7R4D chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.76 Å
- 7R43 chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.78 Å
- 7R45 chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.78 Å
- 7R47 chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.78 Å
- 7R44 chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.79 Å
- 7R4F chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.79 Å
- 7R4G chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.79 Å
- 7R46 chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.82 Å
- 7R42 chain l against the predicted model Q02372: TM-score 0.97, RMSD 0.82 Å
Elsewhere
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