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UniProt Q00578

General transcription and DNA repair factor IIH helicase subunit XPB (Q00578)

General transcription and DNA repair factor IIH helicase subunit XPB (UniProt Q00578), EC 3.6.4.12: 43 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 70 pockets. Binding sites, druggability and…

UniProt
Q00578
Protein
General transcription and DNA repair factor IIH helicase subunit XPB
EC
3.6.4.12
Experimental structures
43
Predicted models
1
Ligands
3
Pockets
70 · 21 records with a druggable one

Structures

44 records of Q00578 in the MolNFT archive: 43 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
5FMFthe P-lobe of RNA polymerase II pre-initiation complexelectron microscopy1——
5FMFThe P-lobe of RNA polymerase II pre-initiation complexelectron microscopy1——
5OQJStructure of yeast transcription pre-initiation complex with tfiihelectron microscopy7——
5OQMStructure of yeast transcription pre-initiation complex with tfiih and core mediatorelectron microscopy7—1 (best 0.84)
5OQMStructure of yeast transcription pre-initiation complex with tfiih and core mediatorelectron microscopy7——
5SVAMediator-RNA Polymerase II Pre-Initiation Complexelectron microscopyZ——
5SVAMediator-RNA polymerase II pre-initiation complexelectron microscopyZ——
6GYMStructure of a yeast closed complex with distorted DNA (CCdist)electron microscopy7——
6GYMStructure of a yeast closed complex with distorted DNA (ccdist)electron microscopy7——
7K01Structure of TFIIH in TFIIH/Rad4-Rad23-Rad33 DNA opening complexelectron microscopy7—6 (best 0.83)
7K01Structure of tfiih in TFIIH/RAD4-RAD23-RAD33 DNA opening complexelectron microscopy7——
7K04Structure of TFIIH/Rad4-Rad23-Rad33/DNA in DNA openingelectron microscopy7—5 (best 0.81)
7K04Structure of TFIIH/RAD4-RAD23-RAD33/DNA in DNA openingelectron microscopy7——
7M2UNucleotide Excision Repair complex TFIIH Rad4-33electron microscopy7—6 (best 0.81)
7M2UNucleotide excision repair complex tfiih RAD4-33electron microscopy7——
7ML0RNA polymerase II pre-initiation complex (PIC1)electron microscopy7——
7ML1RNA polymerase II pre-initiation complex (PIC2)electron microscopy7—2 (best 0.83)
7ML1RNA polymerase II pre-initiation complex (PIC2)electron microscopy7——
7ML2RNA polymerase II pre-initiation complex (PIC3)electron microscopy7—2 (best 0.80)
7ML2RNA polymerase II pre-initiation complex (PIC3)electron microscopy7——
7ML3General transcription factor tfiih (weak binding)electron microscopy7——
7ML4RNA polymerase II initially transcribing complex (ITC)electron microscopy7—1 (best 0.75)
7ML4RNA polymerase II initially transcribing complex (itc)electron microscopy7——
7O4IYeast RNA polymerase II transcription pre-initiation complex with initial transcription bubbleelectron microscopy7BEF, MG, ADP3 (best 0.81)
7O4IYeast RNA polymerase II transcription pre-initiation complex with initial transcription bubbleelectron microscopy7BEF, MG, ADP—
7O4JYeast RNA polymerase II transcription pre-initiation complex (consensus)electron microscopy7BEF, MG, ADP3 (best 0.80)
7O4JYeast RNA polymerase II transcription pre-initiation complex (consensus)electron microscopy7BEF, ADP—
7O4KYeast TFIIH in the contracted state within the pre-initiation complexelectron microscopy7BEF, MG, ADP6 (best 0.83)
7O4KYeast tfiih in the contracted state within the pre-initiation complexelectron microscopy7BEF, MG, ADP—
7O4LYeast TFIIH in the expanded state within the pre-initiation complexelectron microscopy7BEF, MG, ADP6 (best 0.80)
7O4LYeast tfiih in the expanded state within the pre-initiation complexelectron microscopy7BEF, MG, ADP—
7O72Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNAelectron microscopy7BEF, MG, ADP4 (best 0.82)
7O72Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNAelectron microscopy7BEF, MG, ADP—
7O73Yeast RNA polymerase II transcription pre-initiation complex with closed distorted promoter DNAelectron microscopy7BEF, MG, ADP—
7O75Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNAelectron microscopy7BEF, MG, ADP3 (best 0.80)
7O75Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNAelectron microscopy7BEF, MG, ADP—
7ZS9Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome (complex A)electron microscopy7—2 (best 0.82)
7ZSAYeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP…electron microscopy7—4 (best 0.78)
7ZSBYeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP…electron microscopy7—2 (best 0.82)
8CENYeast RNA polymerase II transcription pre-initiation complex with core Mediatorelectron microscopy7—2 (best 0.83)
8CEOYeast RNA polymerase II transcription pre-initiation complex with core Mediator and the +1…electron microscopy7—2 (best 0.83)
8UMIconsensus map of PICdeltaTFIIK form1electron microscopy7MG1 (best 0.82)
8UOQComposite map of PIC_delta_TFIIK form2electron microscopy7MG2 (best 0.86)
Q00578AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih helicase…predictedA—7 (best 0.79)

Ligands

  • MG · Magnesium ion · in 14 records
  • ADP · Adenosine-5'-diphosphate · in 13 records
  • BEF · Beryllium trifluoride ion · in 13 records

Experiment against prediction

Elsewhere

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