MolNFT v1 · #331937 · protein
AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih helicase subunit xpb (Q00578)
Q00578: “AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih helicase subunit xpb…”. 7 pockets (best druggability 0.79). MolNFT v1 #331937 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q00578
- Type
- protein
- Length
- 843 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xCe4913b38f6cdd39cE5A2503280B7fe0683920B8
- Molecule
- General transcription and DNA repair factor iih helicase subunit xpb
- UniProt
- Q00578
- Pockets
- 7 · best druggability 0.79
Structure
1 distinct chain · 36% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General transcription and DNA repair factor iih helicase subunit xpb | protein | 843 | 36% helix, 15% strand | Q00578 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 700 | 0.79 | 0.83 | 87 | empty |
| 2 | 651 | 0.77 | 0.83 | 82 | empty |
| 3 | 396 | 0.61 | 0.77 | 51 | empty |
| 4 | 139 | 0.53 | 0.80 | 24 | empty |
| 5 | 69 | 0.39 | 0.79 | 11 | empty |
Compared structures
- 7O75 · Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNA · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O75 · Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNA · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O4I · Yeast RNA polymerase II transcription pre-initiation complex with initial transcription… · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O4L · Yeast tfiih in the expanded state within the pre-initiation complex · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O4L · Yeast TFIIH in the expanded state within the pre-initiation complex · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O4J · Yeast RNA polymerase II transcription pre-initiation complex (consensus) · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O4J · Yeast RNA polymerase II transcription pre-initiation complex (consensus) · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O72 · Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O72 · Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O73 · Yeast RNA polymerase II transcription pre-initiation complex with closed distorted… · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7O4K · Yeast tfiih in the contracted state within the pre-initiation complex · an experimental structure of the same protein · chain A against 7, TM-score 0.68
- 7ML0 · RNA polymerase II pre-initiation complex (PIC1) · an experimental structure of the same protein · chain A against 7, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00578
- Elsewhere: UniProt Q00578 · AlphaFold DB Q00578
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