MolNFT v1 · #182237 · protein + DNA

RNA polymerase II pre-initiation complex (PIC1)

7ML0: “RNA polymerase II pre-initiation complex (PIC1)”. Electron microscopy, 3 ligands (SF4, ZN, MG). MolNFT v1 #182237 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7ML0
Type: protein + DNA
Length: 8,238 residues
Chains: 28
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: A0A6A5Q1P2, A0A6A5Q4H2, A0A6A5Q0Z3, A0A6A5PTI6, A0A6A5Q456, A0A6L0ZRI7, A0A6A5Q270, A0A6A5Q8C2, A0A7I9EWC2, A0A6A5Q7Q6, A0A6A5Q7A1, A0A6A5PY05, P29055, P41895, A0A6A5PZ00, A0A6A5PTU5, A0A6A5PS93, P13393, A0A6A5Q1C1, A0A6A5Q2X3, Q3E7C1, A0A7I9BTI9, Q00578
Ligands: SF4, ZN, MG

Structure

electron microscopy · 28 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	1398	—	A0A6A5Q1P2
B	—	protein	1147	—	A0A6A5Q4H2
C	—	protein	262	—	A0A6A5Q0Z3
D	—	protein	157	—	A0A6A5PTI6
E	—	protein	213	—	A0A6A5Q456
F	—	protein	83	—	A0A6L0ZRI7
G	—	protein	171	—	A0A6A5Q270
H	—	protein	136	—	A0A6A5Q8C2
I	—	protein	116	—	A0A7I9EWC2
J	—	protein	65	—	A0A6A5Q7Q6
K	—	protein	112	—	A0A6A5Q7A1
L	—	protein	45	—	A0A6A5PY05
M	—	protein	279	—	P29055
Q	—	protein	148	—	P41895
R	—	protein	190	—	A0A6A5PZ00
W	—	protein	191	—	A0A6A5PTU5
X	—	protein	156	—	A0A6A5PS93
O	—	protein	180	—	P13393
T	—	dna	66	—	—
N	—	dna	66	—	—
0	—	protein	753	—	A0A6A5Q1C1
1	—	protein	367	—	—
4	—	protein	284	—	—
6	—	protein	351	—	—
2	—	protein	461	—	A0A6A5Q2X3
5	—	protein	66	—	Q3E7C1
3	—	protein	137	—	A0A7I9BTI9
7	—	protein	638	—	Q00578

Ligands and binding sites

SF4 · Iron/sulfur cluster · ligand · chains 0
ZN · Zinc ion · metal · 17 copies · chains A, B, C, I, J, L, M, W, 4, 6, 3
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7ML0 · RNA polymerase II pre-initiation complex (PIC1) · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A6A5Q1P2
Every structure of UniProt A0A6A5Q4H2
Every structure of UniProt A0A6A5Q0Z3
Every structure of UniProt A0A6A5PTI6
Every structure of UniProt A0A6A5Q456
Every structure of UniProt A0A6L0ZRI7
Every structure of UniProt A0A6A5Q270
Every structure of UniProt A0A6A5Q8C2
Every structure of UniProt A0A7I9EWC2
Every structure of UniProt A0A6A5Q7Q6
Every structure of UniProt A0A6A5Q7A1
Every structure of UniProt A0A6A5PY05
Every structure of UniProt P29055
Every structure of UniProt P41895
Every structure of UniProt A0A6A5PZ00
Every structure of UniProt A0A6A5PTU5
Every structure of UniProt A0A6A5PS93
Every structure of UniProt P13393
Every structure of UniProt A0A6A5Q1C1
Every structure of UniProt A0A6A5Q2X3
Every structure of UniProt Q3E7C1
Every structure of UniProt A0A7I9BTI9
Every structure of UniProt Q00578
Elsewhere: RCSB PDB 7ML0 · PDBe 7ML0 · UniProt A0A6A5Q1P2 · UniProt A0A6A5Q4H2 · UniProt A0A6A5Q0Z3 · UniProt A0A6A5PTI6 · UniProt A0A6A5Q456 · UniProt A0A6L0ZRI7 · UniProt A0A6A5Q270 · UniProt A0A6A5Q8C2 · UniProt A0A7I9EWC2 · UniProt A0A6A5Q7Q6 · UniProt A0A6A5Q7A1 · UniProt A0A6A5PY05 · UniProt P29055 · UniProt P41895 · UniProt A0A6A5PZ00 · UniProt A0A6A5PTU5 · UniProt A0A6A5PS93 · UniProt P13393 · UniProt A0A6A5Q1C1 · UniProt A0A6A5Q2X3 · UniProt Q3E7C1 · UniProt A0A7I9BTI9 · UniProt Q00578

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