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MolNFT v1 · #182239 · protein + DNA

RNA polymerase II pre-initiation complex (PIC3)

7ML2: “RNA polymerase II pre-initiation complex (PIC3)”. Electron microscopy, 3 ligands (SF4, ZN, MG). MolNFT v1 #182239 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
7ML2
Type
protein + DNA
Length
8,315 residues
Chains
30
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
A0A6A5Q1P2, A0A6A5Q4H2, A0A6A5Q0Z3, A0A6A5PTI6, A0A6A5Q456, A0A6L0ZRI7, A0A6A5Q270, A0A6A5Q8C2, A0A7I9EWC2, A0A6A5Q7Q6, A0A6A5Q7A1, A0A6A5PY05, P29055, P41895, A0A6A5PZ00, A0A6A5Q2T8, A0A6A5PRZ0, A0A6A5PTU5, A0A6A5PS93, G4XSG8, A0A6A5Q1C1, A0A6A5Q2X3, Q3E7C1, Q00578, A0A7I9BTI9
Ligands
SF4, ZN, MG

Structure

electron microscopy · 30 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein1398—A0A6A5Q1P2
B—protein1152—A0A6A5Q4H2
C—protein262—A0A6A5Q0Z3
D—protein157—A0A6A5PTI6
E—protein213—A0A6A5Q456
F—protein83—A0A6L0ZRI7
G—protein171—A0A6A5Q270
H—protein136—A0A6A5Q8C2
I—protein116—A0A7I9EWC2
J—protein65—A0A6A5Q7Q6
K—protein112—A0A6A5Q7A1
L—protein45—A0A6A5PY05
M—protein279—P29055
Q—protein148—P41895
R—protein190—A0A6A5PZ00
U—protein46—A0A6A5Q2T8
V—protein49—A0A6A5PRZ0
W—protein191—A0A6A5PTU5
X—protein156—A0A6A5PS93
T—dna56——
N—dna56——
O—protein180—G4XSG8
1—protein367——
4—protein284——
0—protein754—A0A6A5Q1C1
6—protein351——
2—protein460—A0A6A5Q2X3
5—protein66—Q3E7C1
7—protein634—Q00578
3—protein138—A0A7I9BTI9

Ligands and binding sites

  • SF4 · Iron/sulfur cluster · ligand · chains 0
  • ZN · Zinc ion · metal · 17 copies · chains A, B, C, I, J, L, M, W, 4, 6, 3
  • MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7ML2 · RNA polymerase II pre-initiation complex (PIC3) · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

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