UniProt P9WG47
DNA gyrase subunit A (P9WG47)
DNA gyrase subunit A (UniProt P9WG47), EC 5.6.2.2, 5.99.1.3: 21 experimental structures on GenesisL1, 7 ligands bound, 122 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P9WG47
- Protein
- DNA gyrase subunit A
- EC
- 5.6.2.2, 5.99.1.3
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 122 · 8 records with a druggable one
Structures
21 records of P9WG47 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5BS8 | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | MG, MFX | 14 (best 0.85) |
| 5BS8 | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 5BTA | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | MG, MFX | 12 (best 0.86) |
| 5BTA | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 5BTC | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 5BTD | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | GFN, MG | 15 (best 0.84) |
| 5BTD | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 5BTF | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 5BTG | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 5BTI | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | MG, LFX | 11 (best 0.86) |
| 5BTI | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 5BTL | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 5BTN | Crystal structure of a topoisomerase II complex | x-ray diffraction | A, C | — | — |
| 6GAU | Extremely 'open' clamp structure of DNA gyrase: role of the Corynebacteriales GyrB specific insert | x-ray diffraction | A, B | ANP, MG | 20 (best 0.79) |
| 6GAU | Extremely 'open' clamp structure of DNA gyrase: role of the corynebacteriales gyrb specific insert | x-ray diffraction | A, B | ANP, MG | — |
| 6GAV | Extremely 'open' clamp structure of DNA gyrase: role of the Corynebacteriales GyrB specific insert | x-ray diffraction | A, B | — | 20 (best 0.75) |
| 6GAV | Extremely 'open' clamp structure of DNA gyrase: role of the corynebacteriales gyrb specific insert | x-ray diffraction | A, B | — | — |
| 7UGW | M. tuberculosis DNA gyrase cleavage core bound to DNA and evybactin | x-ray diffraction | A, C | — | 13 (best 0.84) |
| 7UGW | M. tuberculosis DNA gyrase cleavage core bound to DNA and evybactin | x-ray diffraction | A, C | — | — |
| 9FOY | Ternary complex of a Mycobacterium tuberculosis DNA gyrase core fusion with DNA and the inhibitor… | x-ray diffraction | A, B | A1ID8, A1ID9 | 17 (best 0.82) |
| P9WG47 | AlphaFold monomer V2.0 prediction for DNA gyrase subunit a (P9WG47) | — | — | — |
Ligands
- MG · Magnesium ion · in 6 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- MFX · 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid · in 2 records
- A1ID8 · (1~{S})-2-[4-[[4-bromanyl-3,5-bis(fluoranyl)phenyl]methylamino]cyclohexyl]-1-(6-methoxy-1,5-naphthyridin-4-yl)ethanol · in 1 record
- A1ID9 · (1~{R})-2-[4-[[4-bromanyl-3,5-bis(fluoranyl)phenyl]methylamino]cyclohexyl]-1-(6-methoxy-1,5-naphthyridin-4-yl)ethanol · in 1 record
- GFN · 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid · in 1 record
- LFX · (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid · in 1 record
Experiment against prediction
- 9FOY chain A against the predicted model P9WG45: TM-score 0.22, RMSD 7.75 Å
- 9FOY chain B against the predicted model P9WG45: TM-score 0.21, RMSD 8.20 Å
Elsewhere
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