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Ligand · CPF

CPF · 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid

CPF, 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid (C17 H18 F N3 O3, 331.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (4 PDB entries). Every binding site with its residues…

Component
CPF
Formula
C17 H18 F N3 O3
Class
ligand
Structures
4
PDB entries
4

Binding sites

CPF in 4 structures; the first of them:

  • 1OYE · Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump · CPF A5001 · binds LYS29
  • 1T9U · Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump · CPF A5001 · binds SER96, GLY97, THR98, PHE388, PHE459, ARG468
  • 8GJL · multi-drug efflux pump RE-CmeB bound with Ciprofloxacin · CPF C1101 · binds ILE136, VAL139, ILE291, PRO327, TYR328, VAL568, MET570, VAL605 and 6 more
  • 8VTY · Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with… · CPF 1A4056 · binds C1782, A2062, U2584, U2585, C2586, U2609

Residues it binds most

PHE 3, U 2, C 2, ILE 1, LEU 1, VAL 1, A 2, ARG 2, ASN 1, SER 2 (residue and the binding sites it lines).

Found with

  • ARG · Arginine
  • SF4 · Iron/sulfur cluster
  • MG · Magnesium ion
  • ZN · Zinc ion
  • MPD · (4S)-2-methyl-2,4-pentanediol

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