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Ligand · GFN

GFN · 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

GFN, 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (C19 H22 F N3 O4, 375.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding…

Component
GFN
Formula
C19 H22 F N3 O4
Class
ligand
Structures
3
PDB entries
2

Binding sites

GFN in 3 structures; the first of them:

  • 5BTD · Crystal structure of a topoisomerase II complex · GFN E101 · binds ALA90, SER91, ARG482, GLY483, THR500, GLU501, ARG128, PTR129 and 8 more
  • 7F35 · Crystal structure of anti S-gatifloxacin antibody Fab fragment in complex with… · GFN A301 · binds PHE34, HIS36, TYR38, LEU48, TYR51, GLN91, THR93, TYR98 and 6 more
  • 7F35 · Crystal structure of anti S-gatifloxacin antibody Fab fragment in complex with… · GFN A301 · binds PHE34, HIS36, TYR38, TYR51, GLN91, THR93, TRP99, ASN100 and 3 more

Residues it binds most

TYR 6, ARG 8, GLU 8, THR 8, ASN 6, DA 2, DT 2, GLN 6, HIS 6, PHE 6 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion
  • CL · Chloride ion
  • SO4 · Sulfate ion
  • CIT · Citric acid
  • EDO · 1,2-ethanediol
  • GOL · Glycerol
  • MG · Magnesium ion

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