UniProt P97275
Alkyldihydroxyacetonephosphate synthase, peroxisomal (P97275)
Alkyldihydroxyacetonephosphate synthase, peroxisomal (UniProt P97275), EC 2.5.1.26: 18 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 360 pockets. Binding sites, druggability and experiment against…
- UniProt
- P97275
- Protein
- Alkyldihydroxyacetonephosphate synthase, peroxisomal
- EC
- 2.5.1.26
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 360 · 18 records with a druggable one
Structures
19 records of P97275 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BBY | Mammalian alkyldihydroxyacetonephosphate synthase: wild-type | x-ray diffraction | A, B, C, D | FAD, SO4 | 20 (best 0.90) |
| 4BBY | Mammalian alkyldihydroxyacetonephosphate synthase: wild-type | x-ray diffraction | A, B, C, D | FAD, SO4 | 20 (best 0.90) |
| 4BC7 | MAMMALIAN ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE: Arg419His mutant | x-ray diffraction | A, B, C, D | FAD, SO4, 1DO | 20 (best 0.89) |
| 4BC7 | Mammalian alkyldihydroxyacetonephosphate synthase: ARG419HIS mutant | x-ray diffraction | A, B, C, D | FAD, SO4, 1DO | 20 (best 0.89) |
| 4BC9 | Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl | x-ray diffraction | A, B, C, D | CNV, FAD, SO4 | 20 (best 0.89) |
| 4BC9 | Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl | x-ray diffraction | A, B, C, D | CNV, FAD, SO4 | 20 (best 0.89) |
| 4BCA | MAMMALIAN ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE: Tyr578Phe mutant | x-ray diffraction | A, B, C, D | FAD, CL, SO4 | 20 (best 0.90) |
| 4BCA | Mammalian alkyldihydroxyacetonephosphate synthase: TYR578PHE mutant | x-ray diffraction | A, B, C, D | FAD, CL, SO4 | 20 (best 0.90) |
| 5ADZ | Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1a | x-ray diffraction | A, B, C, D | FAD, KQS | 20 (best 0.90) |
| 5ADZ | Ether lipid-generating enzyme agps in complex with inhibitor 1A | x-ray diffraction | A, B, C, D | FAD, KQS | 20 (best 0.90) |
| 5AE1 | Ether Lipid-Generating Enzyme AGPS in complex with inhibitor ZINC69435460 | x-ray diffraction | A, B, C, D | B2Z, FAD, SO4 | 20 (best 0.90) |
| 5AE1 | Ether lipid-generating enzyme agps in complex with inhibitor ZINC69435460 | x-ray diffraction | A, B, C, D | B2Z, FAD, SO4 | 20 (best 0.90) |
| 5AE2 | Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1e | x-ray diffraction | A, B, C, D | FYC, FAD, SO4 | 20 (best 0.90) |
| 5AE2 | Ether lipid-generating enzyme agps in complex with inhibitor 1E | x-ray diffraction | A, B, C, D | FYC, FAD, SO4 | 20 (best 0.90) |
| 5AE3 | Ether Lipid-Generating Enzyme AGPS in complex with antimycin A | x-ray diffraction | A, B, C, D | AWB, FAD, SO4 | 20 (best 0.89) |
| 5AE3 | Ether lipid-generating enzyme agps in complex with antimycin a | x-ray diffraction | A, B, C, D | AWB, FAD, SO4 | 20 (best 0.89) |
| 6GOU | Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I | x-ray diffraction | D, A, B, C | FAD, F6T | 20 (best 0.90) |
| 6GOU | Development of alkyl glycerone phosphate synthase inhibitors: complex with inhibitor 2I | x-ray diffraction | D, A, B, C | FAD, F6T | 20 (best 0.90) |
| P97275 | AlphaFold monomer V2.0 prediction for alkyldihydroxyacetonephosphate synthase, peroxisomal (P97275) | predicted | A | — | — |
Ligands
- FAD · Flavin-adenine dinucleotide · in 18 records
- SO4 · Sulfate ion · in 14 records
- 1DO · 1-dodecanol · in 2 records
- AWB · [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 3-methylbutanoate · in 2 records
- B2Z · (3-(2-fluorophenyl)-N-(1-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)ethyl)butanamide) · in 2 records
- CL · Chloride ion · in 2 records
- CNV · propanenitrile · in 2 records
- F6T · (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl) methyl]butanamide · in 2 records
- FYC · 3-(2-fluorophenyl)-2-methyl-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)acrylamide · in 2 records
- KQS · (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide) · in 2 records
Experiment against prediction
- 4BBY chain D against the predicted model P97275: TM-score 0.99, RMSD 0.63 Å
- 4BBY chain D against the predicted model P97275: TM-score 0.99, RMSD 0.63 Å
- 5AE2 chain D against the predicted model P97275: TM-score 0.99, RMSD 0.65 Å
- 5AE2 chain D against the predicted model P97275: TM-score 0.99, RMSD 0.65 Å
- 4BCA chain D against the predicted model P97275: TM-score 0.99, RMSD 0.65 Å
- 4BCA chain D against the predicted model P97275: TM-score 0.99, RMSD 0.65 Å
- 5AE2 chain C against the predicted model P97275: TM-score 0.99, RMSD 0.66 Å
- 5AE2 chain C against the predicted model P97275: TM-score 0.99, RMSD 0.66 Å
- 5ADZ chain C against the predicted model P97275: TM-score 0.99, RMSD 0.67 Å
- 5ADZ chain C against the predicted model P97275: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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