UniProt P82610
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (P82610)
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (UniProt P82610), EC 2.1.1.14: 22 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 250 pockets. Binding sites, druggability and…
- UniProt
- P82610
- Protein
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- EC
- 2.1.1.14
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 250 · 22 records with a druggable one
Structures
23 records of P82610 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3PPC | Crystal structure of the Candida albicans methionine synthase by surface entropy reduction… | x-ray diffraction | A, B | ZN, CL | 20 (best 0.77) |
| 3PPC | Crystal structure of the candida albicans methionine synthase by surface entropy reduction… | x-ray diffraction | A, B | ZN, CL | 20 (best 0.77) |
| 3PPF | Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine… | x-ray diffraction | A | — | 11 (best 0.76) |
| 3PPF | Crystal structure of the candida albicans methionine synthase by surface entropy reduction, alanine… | x-ray diffraction | A | — | 11 (best 0.76) |
| 3PPG | Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, alanine… | x-ray diffraction | A | ZN | 12 (best 0.78) |
| 3PPG | Crystal structure of the candida albicans methionine synthase by surface entropy reduction, alanine… | x-ray diffraction | A | ZN | 12 (best 0.78) |
| 3PPH | Crystal structure of the Candida albicans methionine synthase by surface entropy reduction… | x-ray diffraction | A, B | — | 19 (best 0.78) |
| 3PPH | Crystal structure of the candida albicans methionine synthase by surface entropy reduction… | x-ray diffraction | A, B | — | 19 (best 0.78) |
| 4L5Z | Crystal structure of the Candida albicans Methionine Synthase in complex with Homocysteine | x-ray diffraction | A | ZN, HCS | 8 (best 0.77) |
| 4L5Z | Crystal structure of the candida albicans methionine synthase in complex with homocysteine | x-ray diffraction | A | ZN, HCS | 8 (best 0.77) |
| 4L61 | Crystal structure of the Candida albicans Methionine Synthase in complex with Methionine | x-ray diffraction | A | MET, ZN | 8 (best 0.77) |
| 4L61 | Crystal structure of the candida albicans methionine synthase in complex with methionine | x-ray diffraction | A | MET, ZN | 8 (best 0.77) |
| 4L64 | Crystal structure of the Candida albicans Methionine Synthase in complex with… | x-ray diffraction | A | ZN, C2F | 10 (best 0.78) |
| 4L64 | Crystal structure of the candida albicans methionine synthase in complex with… | x-ray diffraction | A | ZN, C2F | 10 (best 0.78) |
| 4L65 | Crystal structure of the Candida albicans Methionine Synthase in complex with… | x-ray diffraction | A | ZN, C2F, MET | 10 (best 0.79) |
| 4L65 | Crystal structure of the candida albicans methionine synthase in complex with… | x-ray diffraction | A | ZN, C2F, MET | 10 (best 0.79) |
| 4L6H | Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and… | x-ray diffraction | A | ZN, HCS, MTX | 9 (best 0.76) |
| 4L6H | Crystal structure of the candida albicans methionine synthase in complex with methotrexate and… | x-ray diffraction | A | ZN, HCS, MTX | 9 (best 0.76) |
| 4L6O | Crystal structure of the Candida albicans Methionine Synthase in complex with Glutamine | x-ray diffraction | A | ZN, GLN | 8 (best 0.77) |
| 4L6O | Crystal structure of the candida albicans methionine synthase in complex with glutamine | x-ray diffraction | A | ZN, GLN | 8 (best 0.77) |
| 4QQU | Crystal structure of the cobalamin-independent methionine synthase enzyme in a closed conformation | x-ray diffraction | A | HCS, ZN, PO4, 39S | 10 (best 0.79) |
| 4QQU | Crystal structure of the cobalamin-independent methionine synthase enzyme in a closed conformation | x-ray diffraction | A | HCS, ZN, PO4, 39S | 10 (best 0.79) |
| P82610 | AlphaFold monomer V2.0 prediction for 5-methyltetrahydropteroyltriglutamate--homocysteine… | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 18 records
- HCS · 2-amino-4-mercapto-butyric acid · in 6 records
- C2F · 5-methyl-5,6,7,8-tetrahydrofolic acid · in 4 records
- MET · Methionine · in 4 records
- 39S · N-[4-({[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-gamma-glutamyl-L-gamma-glutamyl-L-glutamic acid · in 2 records
- CL · Chloride ion · in 2 records
- GLN · Glutamine · in 2 records
- MTX · Methotrexate · in 2 records
- PO4 · Phosphate ion · in 2 records
Experiment against prediction
- 4QQU chain A against the predicted model P82610: TM-score 0.98, RMSD 1.19 Å
- 4QQU chain A against the predicted model P82610: TM-score 0.98, RMSD 1.19 Å
- 3PPF chain A against the predicted model P82610: TM-score 0.96, RMSD 1.96 Å
- 3PPF chain A against the predicted model P82610: TM-score 0.96, RMSD 1.96 Å
- 4L5Z chain A against the predicted model P82610: TM-score 0.96, RMSD 1.94 Å
- 4L5Z chain A against the predicted model P82610: TM-score 0.96, RMSD 1.94 Å
- 4L65 chain A against the predicted model P82610: TM-score 0.96, RMSD 2.02 Å
- 4L65 chain A against the predicted model P82610: TM-score 0.96, RMSD 2.02 Å
- 4L6H chain A against the predicted model P82610: TM-score 0.96, RMSD 2.10 Å
- 4L6H chain A against the predicted model P82610: TM-score 0.96, RMSD 2.10 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.