Ligand · C2F
C2F · 5-methyl-5,6,7,8-tetrahydrofolic acid
C2F, 5-methyl-5,6,7,8-tetrahydrofolic acid (C20 H25 N7 O6, 459.5 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (12 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…
- Component
- C2F
- Formula
- C20 H25 N7 O6
- Class
- ligand
- Structures
- 12
- PDB entries
- 12
Binding sites
C2F in 12 structures; the first of them:
- 1B02 · Crystal structure of thymidylate synthase a from bacillus subtilis · C2F A281 · binds ALA64, THR67, GLU71, ILE93, TRP94, TRP97, LEU158, CYS161 and 7 more
- 1Q8J · Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima (Cd2+, Hcy… · C2F A801 · binds GLU320, ASN323, ALA325, GLY326, ARG327, ASP358, ASP390, ASN411 and 8 more
- 1TLS · Thymidylate synthase ternary complex with fdump and methylenetetrahydrofolate · C2F A266 · binds LYS48, HIS51, SER54, ILE79, TRP80, TRP83, LEU143, CYS146 and 7 more
- 1TSN · Thymidylate synthase ternary complex with fdump and methylenetetrahydrofolate · C2F A266 · binds LYS48, HIS51, SER54, THR78, ILE79, TRP80, TRP83, LEU143 and 9 more
- 1U1J · A. thaliana cobalamine independent methionine synthase · C2F A773 · binds ARG15, LYS18, ASN116, HIS118, TRP514, SER517, TYR518, SER520 and 4 more
- 1XPG · Crystal Structure of T. maritima Cobalamin-Independent Methionine Synthase complexed with… · C2F A1882 · binds ARG15, LYS18, LYS104, ASN109, HIS111, ASP467, TRP486, SER489 and 8 more
- 1XR2 · Crystal Structure of oxidized T. maritima Cobalamin-Independent Methionine Synthase… · C2F A1200 · binds ARG15, LYS18, LYS104, HIS111, ASP467, TRP486, SER489, TYR490 and 7 more
- 1ZP4 · Glu28Gln mutant of E. coli Methylenetetrahydrofolate Reductase (oxidized) complex with… · C2F A995 · binds GLN28, THR59, ASP120, GLN183, PHE184, LEU212, ASN216, GLN219 and 6 more
- 2E7F · 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with… · C2F A3000 · binds GLU6, ASN9, MET11, PHE12, GLY13, ASP75, ASN96, ILE120 and 9 more
- 5VOO · Methionine synthase folate-binding domain with methyltetrahydrofolate from Thermus… · C2F A3001 · binds GLU373, ARG374, ASN376, GLY379, SER380, LYS381, ASP411, ASP443 and 11 more
- 5VOP · Methionine synthase folate-binding domain from Thermus thermophilus HB8 native · C2F A3001 · binds GLU373, ASN376, GLY379, SER380, LYS381, ASP411, ASP443, ASN464 and 9 more
- 7XLF · Crystal structure of CH3-THF complex of methylenetetrahydrofolate reductase from… · C2F A301 · binds GLU21, THR23, THR46, LEU48, ASP107, GLN175, PHE176, PHE215 and 4 more
Residues it binds most
ASP 23, ASN 17, SER 22, ARG 21, LEU 20, GLY 16, PHE 20, ILE 16, LYS 16, GLU 19 (residue and the binding sites it lines).
Found with
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