MolNFT v1 · #98326 · protein
Crystal structure of the candida albicans methionine synthase in complex with 5-methyl-tetrahydrofolate
4L64 · 5-methyltetrahydropteroyltriglutamate--homocysteine…: “Crystal structure of the candida albicans methionine synthase in complex with 5-methyl-tetrahydrofolate”. X-ray diffraction, 2 ligands (C2F, ZN), 10 pockets (best druggability…
- PDB
- 4L64
- Type
- protein
- Length
- 733 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- EC
- 2.1.1.14
- UniProt
- P82610
- Ligands
- C2F, ZN
- Pockets
- 10 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) | protein | 733 | 46% helix, 15% strand | P82610 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.78 | 0.97 | 28 | empty |
| 2 | 983 | 0.76 | 0.79 | 95 | C2F |
| 3 | 276 | 0.60 | 0.79 | 42 | empty |
| 4 | 171 | 0.55 | 0.80 | 19 | empty |
| 5 | 182 | 0.50 | 0.77 | 23 | empty |
Compared structures
- 4L64 · Crystal structure of the Candida albicans Methionine Synthase in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P82610 · AlphaFold monomer V2.0 prediction for 5-methyltetrahydropteroyltriglutamate--homocysteine… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P82610
- Elsewhere: RCSB PDB 4L64 · PDBe 4L64 · UniProt P82610
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