MolNFT v1 · #75417 · protein

Crystal structure of the candida albicans methionine synthase by surface entropy reduction, alanine variant with zinc

3PPG · 5-methyltetrahydropteroyltriglutamate--homocysteine…: “Crystal structure of the candida albicans methionine synthase by surface entropy reduction, alanine variant…”. X-ray diffraction, 1 ligand (ZN), 12 pockets (best druggability…

PDB: 3PPG
Type: protein
Length: 740 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC: 2.1.1.14
UniProt: P82610
Ligands: ZN
Pockets: 12 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	protein	740	48% helix, 14% strand	P82610

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.78	0.98	25	empty
2	631	0.73	0.80	56	empty
3	323	0.60	0.77	44	empty
4	186	0.58	0.81	20	empty
5	85	0.52	0.84	20	empty

Compared structures

3PPG · Crystal structure of the Candida albicans methionine synthase by surface entropy… · the same entry in another collection · chain A against A, TM-score 1.00
P82610 · AlphaFold monomer V2.0 prediction for 5-methyltetrahydropteroyltriglutamate--homocysteine… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P82610
Elsewhere: RCSB PDB 3PPG · PDBe 3PPG · UniProt P82610

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