MolNFT v1 · #98340 · protein
Crystal structure of the candida albicans methionine synthase in complex with glutamine
4L6O · 5-methyltetrahydropteroyltriglutamate--homocysteine…: “Crystal structure of the candida albicans methionine synthase in complex with glutamine”. X-ray diffraction, 2 ligands (GLN, ZN), 8 pockets (best druggability 0.77). MolNFT v1…
- PDB
- 4L6O
- Type
- protein
- Length
- 746 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- EC
- 2.1.1.14
- UniProt
- P82610
- Ligands
- GLN, ZN
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) | protein | 746 | 47% helix, 14% strand | P82610 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1097 | 0.77 | 0.79 | 105 | GLN |
| 2 | 329 | 0.75 | 0.86 | 48 | empty |
| 3 | 153 | 0.56 | 0.81 | 24 | empty |
| 4 | 67 | 0.51 | 0.85 | 20 | empty |
| 5 | 232 | 0.46 | 0.73 | 22 | empty |
Compared structures
- 4L6O · Crystal structure of the Candida albicans Methionine Synthase in complex with Glutamine · the same entry in another collection · chain A against A, TM-score 1.00
- P82610 · AlphaFold monomer V2.0 prediction for 5-methyltetrahydropteroyltriglutamate--homocysteine… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P82610
- Elsewhere: RCSB PDB 4L6O · PDBe 4L6O · UniProt P82610
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