UniProt P72525
DNA topoisomerase 4 subunit B,DNA topoisomerase 4 subunit A (P72525)
DNA topoisomerase 4 subunit B,DNA topoisomerase 4 subunit A (UniProt P72525), EC 5.6.2.2, 5.99.1.3: 36 experimental structures on GenesisL1, 5 ligands bound, 50 pockets. Binding sites, pockets, druggability and 3D structures in…
- UniProt
- P72525
- Protein
- DNA topoisomerase 4 subunit B,DNA topoisomerase 4 subunit A
- EC
- 5.6.2.2, 5.99.1.3
- Experimental structures
- 36
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 50 · 3 records with a druggable one
Structures
36 records of P72525 in the MolNFT archive: 36 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NOV | Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone… | x-ray diffraction | A, B, C, D | — | — |
| 2NOV | Breakage-reunion domain of S.PNEUMONIAE topo IV: crystal structure of a gram-positive quinolone… | x-ray diffraction | A, B, C, D | — | — |
| 3FOE | Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases | x-ray diffraction | A, B | — | — |
| 3FOE | Structural insight into the quinolone-DNA cleavage complex of type iia topoisomerases | x-ray diffraction | A, B | — | — |
| 3FOF | Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases | x-ray diffraction | A, B | — | — |
| 3FOF | Structural insight into the quinolone-DNA cleavage complex of type iia topoisomerases | x-ray diffraction | A, B | — | — |
| 3K9F | Detailed structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases | x-ray diffraction | A, B | — | — |
| 3K9F | Detailed structural insight into the quinolone-DNA cleavage complex of type iia topoisomerases | x-ray diffraction | A, B | — | — |
| 3KSA | Detailed structural insight into the DNA cleavage complex of type IIA topoisomerases (cleaved form) | x-ray diffraction | A, B | — | — |
| 3KSA | Detailed structural insight into the DNA cleavage complex of type iia topoisomerases (cleaved form) | x-ray diffraction | A, B | — | — |
| 3KSB | Detailed structural insight into the DNA cleavage complex of type IIA topoisomerases (re-sealed… | x-ray diffraction | A, B | — | — |
| 3KSB | Detailed structural insight into the DNA cleavage complex of type iia topoisomerases (re-sealed… | x-ray diffraction | A, B | — | — |
| 3LTN | Inhibitor-stabilized topoisomerase IV-DNA cleavage complex (S. pneumoniae) | x-ray diffraction | A, B | — | — |
| 3LTN | Inhibitor-stabilized topoisomerase IV-DNA cleavage complex (S. pneumoniae) | x-ray diffraction | A, B | — | — |
| 3RAD | Quinolone(Clinafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 3RAD | QUINOLONE(CLINAFLOXACIN)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 3RAE | Quinolone(Levofloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 3RAE | QUINOLONE(LEVOFLOXACIN)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 3RAF | Quinazolinedione-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 3RAF | Quinazolinedione-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 4JUO | A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space… | x-ray diffraction | A | — | — |
| 4JUO | A low-resolution three-gate structure of topoisomerase IV from streptococcus pneumoniae in space… | x-ray diffraction | A | — | — |
| 4KOE | Quinolone(Trovafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 4KOE | QUINOLONE(TROVAFLOXACIN)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 4KPE | Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate | x-ray diffraction | A, B | — | — |
| 4KPE | Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate | x-ray diffraction | A, B | — | — |
| 4KPF | Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate | x-ray diffraction | A, B | — | — |
| 4KPF | Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate | x-ray diffraction | A, B | — | — |
| 4Z3O | Quinolone(Moxifloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae | x-ray diffraction | A, B | MG, MFX | 17 (best 0.79) |
| 4Z3O | QUINOLONE(MOXIFLOXACIN)-DNA cleavage complex of topoisomerase IV from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 4Z4Q | Quinazolinedione(PD 0305970)-DNA cleavage complex of topoisomerase IV from S. pneumoniae | x-ray diffraction | A, B | MG, PDQ | 17 (best 0.77) |
| 4Z4Q | QUINAZOLINEDIONE(PD 0305970)-DNA cleavage complex of topoisomerase IV from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 4Z53 | Quinolone(Trovafloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 4Z53 | QUINOLONE(TROVAFLOXACIN)-DNA cleavage complex of topoisomerase IV from S. pneumoniae | x-ray diffraction | A, B | — | — |
| 8QMB | Nucleant-assisted 2.0 A resolution structure of the Streptococcus pneumoniae topoisomerase… | x-ray diffraction | A, B | MG, CL, TE9 | 16 (best 0.85) |
| P72525 | AlphaFold monomer V2.0 prediction for DNA topoisomerase 4 subunit a (P72525) | — | — | — |
Ligands
- MG · Magnesium ion · in 3 records
- CL · Chloride ion · in 1 record
- MFX · 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid · in 1 record
- PDQ · 3-amino-7-{(3R)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methylquinazoline-2,4(1H,3H)-dione · in 1 record
- TE9 · delafloxacin · in 1 record
Elsewhere
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