GL1X · GenesisL1 explorer

Ligand · NFX

NFX · 7-[(3R)-3-aminopyrrolidin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

NFX, 7-[(3R)-3-aminopyrrolidin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (C17 H17 Cl F N3 O3, 365.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding…

Component
NFX
Formula
C17 H17 Cl F N3 O3
Class
ligand
Structures
4
PDB entries
2

Binding sites

NFX in 4 structures; the first of them:

  • 3FOE · Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases · NFX F0 · binds GLY77, ASP78, SER79, SER80, DA1, DT15, DT4, DA5
  • 3RAD · Quinolone(Clinafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae · NFX F101 · binds SER79, ARG117, ARG456, GLY457, DT15, DC4, DA5, DG1
  • 3FOE · Structural insight into the quinolone-DNA cleavage complex of type iia topoisomerases · NFX F0 · binds GLY77, ASP78, SER79, SER80, DA1, DT15, DT4, DA5
  • 3RAD · QUINOLONE(CLINAFLOXACIN)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae · NFX F101 · binds SER79, ARG117, ARG456, GLY457, DT15, DC4, DA5, DG1

Residues it binds most

DA 8, DT 8, SER 8, ARG 4, GLY 8, ASP 4, DC 4, DG 4, GLU 2 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.