UniProt P63098
Beta-2 adrenergic receptor,Calcineurin subunit B type 1 (P63098)
Beta-2 adrenergic receptor,Calcineurin subunit B type 1 (UniProt P63098): 25 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P63098
- Protein
- Beta-2 adrenergic receptor,Calcineurin subunit B type 1
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 12 · 2 records with a druggable one
Structures
26 records of P63098 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AUI | Human calcineurin heterodimer | x-ray diffraction | B | — | — |
| 1AUI | Human calcineurin heterodimer | x-ray diffraction | B | — | — |
| 1M63 | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of… | x-ray diffraction | B, F | — | — |
| 1M63 | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of… | x-ray diffraction | B, F | — | — |
| 1MF8 | Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin | x-ray diffraction | B | — | — |
| 1MF8 | Crystal structure of human calcineurin complexed with cyclosporin a and human cyclophilin | x-ray diffraction | B | — | — |
| 2P6B | Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide | x-ray diffraction | B, D | — | — |
| 2P6B | Crystal structure of human calcineurin in complex with pvivit peptide | x-ray diffraction | B, D | — | — |
| 3LL8 | Crystal Structure of Calcineurin in Complex with AKAP79 Peptide | x-ray diffraction | B, D | — | — |
| 3LL8 | Crystal structure of calcineurin in complex with AKAP79 peptide | x-ray diffraction | B, D | — | — |
| 4F0Z | Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African… | x-ray diffraction | B | — | — |
| 4F0Z | Crystal structure of calcineurin in complex with the calcineurin- inhibiting domain of the african… | x-ray diffraction | B | — | — |
| 4OR9 | Crystal structure of human calcineurin | x-ray diffraction | B | — | — |
| 4OR9 | Crystal structure of human calcineurin | x-ray diffraction | B | — | — |
| 4ORA | Crystal structure of a human calcineurin mutant | x-ray diffraction | B | — | — |
| 4ORA | Crystal structure of a human calcineurin mutant | x-ray diffraction | B | — | — |
| 4ORC | Crystal structure of mammalian calcineurin | x-ray diffraction | B | — | — |
| 4ORC | Crystal structure of mammalian calcineurin | x-ray diffraction | B | — | — |
| 5SVE | Structure of Calcineurin in complex with NFATc1 LxVP peptide | x-ray diffraction | B | CA | 4 (best 0.62) |
| 5SVE | Structure of calcineurin in complex with NFATC1 lxvp peptide | x-ray diffraction | B | CA | — |
| 6NUC | Structure of calcineurin in complex with NHE1 peptide | x-ray diffraction | B | CA | — |
| 6NUF | Structure of calcineurin in complex with NHE1 peptide | x-ray diffraction | B | CA | — |
| 6NUU | Structure of calcineurin mutant in complex with NHE1 peptide | x-ray diffraction | B | CA | — |
| 7U0T | Crystal structure of a human calcineurin a - calcineurin B fusion bound to FKBP12 and fk-520 | x-ray diffraction | A | CA, KXX | — |
| 9CHU | Cryo-EM structure of calcineurin fused beta2 adrenergic receptor in norepinephrine bound inactive… | electron microscopy | A | E5E, FK5 | 8 (best 0.80) |
| P63098 | AlphaFold monomer V2.0 prediction for calcineurin subunit B type 1 (P63098) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 6 records
- E5E · Noradrenaline · in 1 record
- FK5 · 8-deethyl-8-[but-3-enyl]-ascomycin · in 1 record
- KXX · (3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,22r,26as)-8-ethyl-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4, 10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19, 24,25,26,26A-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone · in 1 record
Experiment against prediction
- 2P6B chain D against the predicted model P63098: TM-score 0.98, RMSD 0.67 Å
- 2P6B chain D against the predicted model P63098: TM-score 0.98, RMSD 0.67 Å
- 3LL8 chain D against the predicted model P63098: TM-score 0.98, RMSD 0.70 Å
- 3LL8 chain D against the predicted model P63098: TM-score 0.98, RMSD 0.70 Å
- 6NUF chain B against the predicted model P63098: TM-score 0.97, RMSD 0.82 Å
- 3LL8 chain B against the predicted model P63098: TM-score 0.97, RMSD 0.82 Å
- 3LL8 chain B against the predicted model P63098: TM-score 0.97, RMSD 0.82 Å
- 6NUC chain B against the predicted model P63098: TM-score 0.97, RMSD 0.83 Å
- 6NUU chain B against the predicted model P63098: TM-score 0.97, RMSD 0.85 Å
- 2P6B chain B against the predicted model P63098: TM-score 0.96, RMSD 0.90 Å
Elsewhere
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