UniProt P62136
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (UniProt P62136), EC 3.1.3.16: 53 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 29 pockets. Binding sites, druggability and…
- UniProt
- P62136
- Protein
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- EC
- 3.1.3.16
- Experimental structures
- 53
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 29 · 4 records with a druggable one
Structures
54 records of P62136 in the MolNFT archive: 53 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3E7A | Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin Nodularin-R | x-ray diffraction | A, B | — | — |
| 3E7A | Crystal structure of protein phosphatase-1 bound to the natural toxin nodularin-R | x-ray diffraction | A, B | — | — |
| 3E7B | Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin inhibitor Tautomycin | x-ray diffraction | A, B | — | — |
| 3E7B | Crystal structure of protein phosphatase-1 bound to the natural toxin inhibitor tautomycin | x-ray diffraction | A, B | — | — |
| 3EGG | Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and… | x-ray diffraction | A, B | — | — |
| 3EGG | Crystal structure of a complex between protein phosphatase 1 alpha (PP1) and the PP1 binding and… | x-ray diffraction | A, B | — | — |
| 3EGH | Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1), the PP1 binding and PDZ… | x-ray diffraction | A, B | — | — |
| 3EGH | Crystal structure of a complex between protein phosphatase 1 alpha (PP1), the PP1 binding and PDZ… | x-ray diffraction | A, B | — | — |
| 3HVQ | Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and… | x-ray diffraction | A, B | — | — |
| 3HVQ | Crystal structure of a complex between protein phosphatase 1 alpha (PP1) and the PP1 binding and… | x-ray diffraction | A, B | — | — |
| 3N5U | Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1 | x-ray diffraction | A, B | — | — |
| 3N5U | Crystal structure of an rb C-terminal peptide bound to the catalytic subunit of PP1 | x-ray diffraction | A, B | — | — |
| 3V4Y | Crystal Structure of the first Nuclear PP1 holoenzyme | x-ray diffraction | A, C, E, G | — | — |
| 3V4Y | Crystal structure of the first nuclear PP1 holoenzyme | x-ray diffraction | A, C, E, G | — | — |
| 4G9J | Protein Ser/Thr phosphatase-1 in complex with cell-permeable peptide | x-ray diffraction | A, B | — | — |
| 4G9J | Protein SER/THR phosphatase-1 in complex with cell-permeable peptide | x-ray diffraction | A, B | — | — |
| 4MOV | 1.45 A Resolution Crystal Structure of Protein Phosphatase 1 | x-ray diffraction | A, B | — | — |
| 4MOV | 1.45 a resolution crystal structure of protein phosphatase 1 | x-ray diffraction | A, B | — | — |
| 4MOY | Structure of a second nuclear PP1 Holoenzyme, crystal form 1 | x-ray diffraction | A | — | — |
| 4MOY | Structure of a second nuclear PP1 holoenzyme, crystal form 1 | x-ray diffraction | A | — | — |
| 4MP0 | Structure of a second nuclear PP1 Holoenzyme, crystal form 2 | x-ray diffraction | A, C | — | — |
| 4MP0 | Structure of a second nuclear PP1 holoenzyme, crystal form 2 | x-ray diffraction | A, C | — | — |
| 4XPN | Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GADD34 | x-ray diffraction | A, C | — | — |
| 4XPN | Crystal structure of protein phosphate 1 complexed with PP1 binding domain of GADD34 | x-ray diffraction | A, C | — | — |
| 5IOH | RepoMan-PP1a (protein phosphatase 1, alpha isoform) holoenzyme complex | x-ray diffraction | A, C | — | — |
| 5IOH | Repoman-PP1A (protein phosphatase 1, alpha isoform) holoenzyme complex | x-ray diffraction | A, C | — | — |
| 6ALZ | Crystal structure of protein phosphatase 1 bound to the natural inhibitor tautomycetin | x-ray diffraction | A, B | MN, BKM, CL | — |
| 6CZO | The KNL1-PP1 holoenzyme | x-ray diffraction | A, C | MN, PO4 | — |
| 6DCX | Iaspp-pp-1C structure and targeting of P53 | x-ray diffraction | A, B | — | — |
| 6DNO | Crystal structure of protein phosphatase 1 (PP1) bound to the muscle glycogen-targeting subunit (gm) | x-ray diffraction | A | 1ZN | — |
| 6G0I | Active fe-PP1 | x-ray diffraction | A | PO4, FE, MN | — |
| 6G0J | Inactive fe-PP1 | x-ray diffraction | A | FE, MN, PO4 | — |
| 6GHM | Structure of PP1 alpha phosphatase bound to ASPP2 | x-ray diffraction | A, B | MN | — |
| 6OBN | The crystal structure of coexpressed SDS22:PP1 complex | x-ray diffraction | A, B | PO4, FE, CL | — |
| 6OBP | Reconstituted PP1 holoenzyme | x-ray diffraction | A | PO4, MN, CL | — |
| 6OBQ | PP1 H66K in complex with microcystin lr | x-ray diffraction | A, B | 1ZN, MN | — |
| 6OBR | PP1 Y134A in complex with Microcystin LR | x-ray diffraction | A, B | MN, CL | 7 (best 0.56) |
| 6OBR | PP1 Y134A in complex with microcystin lr | x-ray diffraction | A, B | 1ZN, MN, CL | — |
| 6OBS | PP1 Y134K | x-ray diffraction | A, B | MN, PO4 | — |
| 6OBU | PP1 Y134K in complex with microcystin lr | x-ray diffraction | A, B | 1ZN, MN, CL | — |
| 6ZEE | Structure of PP1(7-300) bound to PHACTR1 (507-580) at PH8.4 | x-ray diffraction | P, Q, B, A, I, K | MN, SO4, 16P | — |
| 6ZEF | Structure of PP1(7-300) bound to Phactr1 (516-580) at pH 5.25 | x-ray diffraction | A, B | CL, MN | 12 (best 0.64) |
| 6ZEF | Structure of PP1(7-300) bound to PHACTR1 (516-580) at pH 5.25 | x-ray diffraction | A, B | CL, MN | — |
| 6ZEG | Structure of PP1-IRSP53 chimera [PP1(7-304) + linker (G/S)X9 + IRSP53(449-465)] bound to PHACTR1… | x-ray diffraction | A, B | MN, PO4, 16P | — |
| 6ZEH | Structure of PP1-spectrin alpha II chimera [PP1(7-304) + linker (G/S) X9 + spectrin alpha II… | x-ray diffraction | A, B | MN, PO4, SO4 | — |
| 6ZEI | Structure of PP1-IRSP53 S455E chimera [PP1(7-304) + linker (G/S)X9 + IRSP53(449-465)] bound to… | x-ray diffraction | A, B | MN, PO4 | — |
| 6ZEJ | Structure of PP1-PHACTR1 chimera [PP1(7-304) + linker (sgsgs) + PHACTR1(526-580)] | x-ray diffraction | D, A, F, I, L, O | MN | — |
| 6ZK6 | Protein phosphatase 1 (PP1) T320E mutant | x-ray diffraction | A | MN, FE, PO4 | — |
| 7TVF | Crystal structure of the SHOC2-mras-PP1CA (smp) complex to a resolution of 2.17 ångström | x-ray diffraction | F, C | SO4, MN, NA, PO4, CL | — |
| 7TXH | Human mras Q71R in complex with human SHOC2 lrr domain M173I and human PP1CA | x-ray diffraction | C, F | MN, PO4 | — |
| 7UPI | Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex | electron microscopy | B | MN, CL | 8 (best 0.86) |
| 7UPI | Cryo-EM structure of SHOC2-PP1C-mras holophosphatase complex | electron microscopy | B | MN, CL | — |
| 8DWK | Inhibitor-3:PP1 reconstituted complex | x-ray diffraction | A, B | MN | — |
| P62136 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase PP1-alpha catalytic… | predicted | A | — | 2 (best 0.60) |
Ligands
- MN · Manganese (II) ion · in 24 records
- PO4 · Phosphate ion · in 12 records
- CL · Chloride ion · in 11 records
- 1ZN · (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid · in 4 records
- FE · Fe (III) ion · in 4 records
- SO4 · Sulfate ion · in 3 records
- 16P · 3,6,9,12,15,18-hexaoxaicosane · in 2 records
- BKM · (2Z)-2-[(1R)-3-{[(2R,3S,4R,7S,8S,11S,13R,16E)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 4MP0 chain C against the predicted model P62136: TM-score 1.00, RMSD 0.26 Å
- 4MP0 chain C against the predicted model P62136: TM-score 1.00, RMSD 0.26 Å
- 6G0I chain A against the predicted model P62136: TM-score 1.00, RMSD 0.29 Å
- 7TVF chain F against the predicted model P62136: TM-score 1.00, RMSD 0.30 Å
- 6CZO chain A against the predicted model P62136: TM-score 1.00, RMSD 0.32 Å
- 7TXH chain C against the predicted model P62136: TM-score 1.00, RMSD 0.33 Å
- 4XPN chain C against the predicted model P62136: TM-score 1.00, RMSD 0.35 Å
- 4XPN chain C against the predicted model P62136: TM-score 1.00, RMSD 0.35 Å
- 6ZEF chain A against the predicted model P62136: TM-score 1.00, RMSD 0.39 Å
- 6ZEF chain A against the predicted model P62136: TM-score 1.00, RMSD 0.39 Å
Elsewhere
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