UniProt P61964
WD repeat-containing protein 5 (P61964)
WD repeat-containing protein 5 (UniProt P61964): 241 experimental structures on GenesisL1, 75 ligands bound, 142 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P61964
- Protein
- WD repeat-containing protein 5
- Experimental structures
- 241
- Predicted models
- 0
- Ligands
- 75
- Pockets
- 142 · 50 records with a druggable one
Structures
241 records of P61964 in the MolNFT archive: 241 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CNX | WDR5 and Histone H3 Lysine 4 dimethyl complex at 2.1 angstrom | x-ray diffraction | A | — | — |
| 2CNX | WDR5 and histone H3 lysine 4 dimethyl complex at 2.1 ångström | x-ray diffraction | A | — | — |
| 2CO0 | WDR5 and unmodified Histone H3 complex at 2.25 Angstrom | x-ray diffraction | A, C | — | — |
| 2CO0 | WDR5 and unmodified histone H3 complex at 2.25 ångström | x-ray diffraction | A, C | — | — |
| 2G99 | Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40… | x-ray diffraction | A, B | — | — |
| 2G99 | Structural basis for the specific recognition of methylated histone H3 lysine 4 by the wd-40… | x-ray diffraction | A, B | — | — |
| 2G9A | Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40… | x-ray diffraction | A | — | — |
| 2G9A | Structural basis for the specific recognition of methylated histone H3 lysine 4 by the wd-40… | x-ray diffraction | A | — | — |
| 2GNQ | Structure of wdr5 | x-ray diffraction | A | — | — |
| 2GNQ | Structure of WDR5 | x-ray diffraction | A | — | — |
| 2H13 | Crystal structure of WDR5/histone H3 complex | x-ray diffraction | A | — | — |
| 2H13 | Crystal structure of WDR5/HISTONE H3 complex | x-ray diffraction | A | — | — |
| 2H14 | Crystal of WDR5 (apo-form) | x-ray diffraction | A | — | — |
| 2H14 | Crystal of WDR5 (apo-form) | x-ray diffraction | A | — | — |
| 2H68 | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | x-ray diffraction | A, B | — | — |
| 2H68 | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | x-ray diffraction | A, B | — | — |
| 2H6K | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | x-ray diffraction | A, B | — | — |
| 2H6K | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | x-ray diffraction | A, B | — | — |
| 2H6N | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | x-ray diffraction | A, B | — | — |
| 2H6N | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | x-ray diffraction | A, B | — | — |
| 2H6Q | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | x-ray diffraction | A, B | — | — |
| 2H6Q | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | x-ray diffraction | A, B | — | — |
| 2H9L | WDR5delta23 | x-ray diffraction | A | — | — |
| 2H9L | WDR5DELTA23 | x-ray diffraction | A | — | — |
| 2H9M | WDR5 in complex with unmodified H3K4 peptide | x-ray diffraction | A, C | — | — |
| 2H9M | WDR5 in complex with unmodified H3K4 peptide | x-ray diffraction | A, C | — | — |
| 2H9N | WDR5 in complex with monomethylated H3K4 peptide | x-ray diffraction | A, C | — | — |
| 2H9N | WDR5 in complex with monomethylated H3K4 peptide | x-ray diffraction | A, C | — | — |
| 2H9P | WDR5 in complex with trimethylated H3K4 peptide | x-ray diffraction | A | — | — |
| 2H9P | WDR5 in complex with trimethylated H3K4 peptide | x-ray diffraction | A | — | — |
| 2O9K | WDR5 in Complex with Dimethylated H3K4 Peptide | x-ray diffraction | A, C | — | — |
| 2O9K | WDR5 in complex with dimethylated H3K4 peptide | x-ray diffraction | A, C | — | — |
| 3EG6 | Structure of WDR5 bound to MLL1 peptide | x-ray diffraction | A | — | — |
| 3EG6 | Structure of WDR5 bound to MLL1 peptide | x-ray diffraction | A | — | — |
| 3EMH | Structural basis of WDR5-MLL interaction | x-ray diffraction | A | — | — |
| 3EMH | Structural basis of WDR5-mll interaction | x-ray diffraction | A | — | — |
| 3MXX | Crystal structure of WDR5 mutant (S62A) | x-ray diffraction | A | — | — |
| 3MXX | Crystal structure of WDR5 mutant (S62A) | x-ray diffraction | A | — | — |
| 3N0D | Crystal structure of WDR5 mutant (W330F) | x-ray diffraction | A | — | — |
| 3N0D | Crystal structure of WDR5 mutant (W330F) | x-ray diffraction | A | — | — |
| 3N0E | Crystal structure of WDR5 mutant (W330Y) | x-ray diffraction | A | — | — |
| 3N0E | Crystal structure of WDR5 mutant (W330Y) | x-ray diffraction | A | — | — |
| 3P4F | Structural and biochemical insights into MLL1 core complex assembly and regulation. | x-ray diffraction | A | — | — |
| 3P4F | Structural and biochemical insights into MLL1 core complex assembly and regulation. | x-ray diffraction | A | — | — |
| 3PSL | Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic | x-ray diffraction | A, B | — | — |
| 3PSL | Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic | x-ray diffraction | A, B | — | — |
| 3SMR | Crystal structure of human WD repeat domain 5 with compound | x-ray diffraction | A, B, C, D | — | — |
| 3SMR | Crystal structure of human wd repeat domain 5 with compound | x-ray diffraction | A, B, C, D | — | — |
| 3UR4 | Crystal structure of human WD repeat domain 5 with compound | x-ray diffraction | A, B | — | — |
| 3UR4 | Crystal structure of human wd repeat domain 5 with compound | x-ray diffraction | A, B | — | — |
| 3UVK | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2 | x-ray diffraction | A | — | — |
| 3UVK | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2 | x-ray diffraction | A | — | — |
| 3UVL | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3 | x-ray diffraction | A | — | — |
| 3UVL | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3 | x-ray diffraction | A | — | — |
| 3UVM | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4 | x-ray diffraction | A | — | — |
| 3UVM | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4 | x-ray diffraction | A | — | — |
| 3UVN | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A | x-ray diffraction | A, C | — | — |
| 3UVN | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A | x-ray diffraction | A, C | — | — |
| 3UVO | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B | x-ray diffraction | A | — | — |
| 3UVO | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B | x-ray diffraction | A | — | — |
181 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 33 records
- CL · Chloride ion · in 6 records
- UNX · Unknown atom or ion · in 5 records
- ALQ · 2-methyl-propionic acid · in 4 records
- S7Z · (E)-(4-((2,6-difluoro-4-(hydroxymethyl)phenyl) diazenyl)-2,6-difluorophenyl)methanol · in 4 records
- SCN · Thiocyanate ion · in 4 records
- ACE · Acetyl group · in 3 records
- NA · Sodium ion · in 3 records
- SRO · Serotonin · in 3 records
- G2D · N-[(1R)-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl]-3-methoxy-4-methylbenzamide · in 2 records
- G2V · 6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1-methylindoline · in 2 records
- HH7 · N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine · in 2 records
- HLM · N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide · in 2 records
- HLP · 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid · in 2 records
- HLS · 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3, 5-dimethoxyphenyl)methyl]-4-fluorobenzamide · in 2 records
- K · Potassium ion · in 2 records
- OGM · methyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate · in 2 records
- OH7 · N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}acetamide · in 2 records
- OHJ · (2-butyl-1H-imidazol-4-yl)methanol · in 2 records
- Q0M · 3-{[(5-bromo-3-chloro-2-hydroxyphenyl)sulfonyl]amino}-5-(1-cyanocyclobutyl)-2-hydroxy-N-methylbenzamide · in 2 records
- Q0Y · 5-bromo-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzene-1-sulfonamide · in 2 records
- Q1J · 5-bromo-N-(4-hydroxy[1,1'-biphenyl]-3-yl)-2-methoxybenzene-1-sulfonamide · in 2 records
- Q1M · 3-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-5-chloro-2-hydroxybenzoic acid · in 2 records
- Q1P · 3-{[(5-bromo-2-hydroxyphenyl)sulfonyl]amino}-5-cyclopropyl-6-fluoro-2-hydroxybenzoic acid · in 2 records
- Q1S · N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]isoquinolin-1-amine · in 2 records
- Q3X · ~{N}-[5-[4-[2-[2-[2-[2-[3-[[3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-3~{H}-pyridine-3-carboxamide · in 2 records
- Q8G · 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid · in 2 records
- Q8S · 5-bromo-3-chloro-N-(1-cyclopentyl-2-methyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide · in 2 records
- QBM · 6-methyl-3-(propylsulfanyl)-1,2,4-triazin-5-ol · in 2 records
- QBS · (2R)-2-(4-chlorophenyl)-3-oxobutanenitrile · in 2 records
Elsewhere
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