UniProt P60842
Eukaryotic initiation factor 4A-I (P60842)
Eukaryotic initiation factor 4A-I (UniProt P60842), EC 3.6.4.13: 16 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P60842
- Protein
- Eukaryotic initiation factor 4A-I
- EC
- 3.6.4.13
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 18 · 4 records with a druggable one
Structures
17 records of P60842 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G9N | Structure of the DEAD domain of Human eukaryotic initiation factor 4A, eIF4A | x-ray diffraction | A, B | — | — |
| 2G9N | Structure of the dead domain of human eukaryotic initiation factor 4A, EIF4A | x-ray diffraction | A, B | — | — |
| 2ZU6 | crystal structure of the eIF4A-PDCD4 complex | x-ray diffraction | A, C, D, F | — | — |
| 2ZU6 | Crystal structure of the EIF4A-PDCD4 complex | x-ray diffraction | A, C, D, F | — | — |
| 3EIQ | Crystal structure of Pdcd4-eIF4A | x-ray diffraction | A, D | — | — |
| 3EIQ | Crystal structure of PDCD4-EIF4A | x-ray diffraction | A, D | — | — |
| 5ZBZ | Crystal structure of the dead domain of human EIF4A with sanguinarine | x-ray diffraction | A | SAU | — |
| 5ZC9 | Crystal structure of the human EIF4A1-ATP analog-roca-polypurine RNA complex | x-ray diffraction | A | ANP, MG, RCG | — |
| 7PPZ | Crystal structure of the Burkholderia Lethal Factor 1 (BLF1) C94S inactive mutant in complex with… | x-ray diffraction | B | — | 6 (best 0.76) |
| 7PPZ | Crystal structure of the burkholderia lethal factor 1 (BLF1) C94S inactive mutant in complex with… | x-ray diffraction | B | — | — |
| 7PQ0 | Crystal structure of the Burkholderia Lethal Factor 1 (BLF1) C94S inactive mutant in complex with… | x-ray diffraction | B | — | 4 (best 0.78) |
| 7PQ0 | Crystal structure of the burkholderia lethal factor 1 (BLF1) C94S inactive mutant in complex with… | x-ray diffraction | B | — | — |
| 8HUJ | Cryo-EM structure of the J-K-St region of EMCV IRES in complex with eIF4G-HEAT1 and eIF4A | electron microscopy | A | — | 5 (best 0.63) |
| 8OZ0 | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | electron microscopy | 3, 1 | — | — |
| 8XXN | Cryo-EM structure of the human 43S ribosome with PDCD4 | electron microscopy | 4A | — | — |
| 9AVR | Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol | x-ray diffraction | A | ANP, MG, IOD, A1AG8 | 3 (best 0.65) |
| P60842 | AlphaFold monomer V2.0 prediction for eukaryotic initiation factor 4A-I (P60842) | predicted | A | — | — |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- MG · Magnesium ion · in 2 records
- A1AG8 · silvestrol · in 1 record
- IOD · Iodide ion · in 1 record
- RCG · (1r,2r,3s,3ar,8bs)-6,8-dimethoxy-3A-(4-methoxyphenyl)-N,N-dimethyl-1,8B-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide · in 1 record
- SAU · 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium · in 1 record
Experiment against prediction
- 2G9N chain B against the predicted model P60842: TM-score 0.98, RMSD 1.01 Å
- 2G9N chain B against the predicted model P60842: TM-score 0.98, RMSD 1.01 Å
- 9AVR chain A against the predicted model P60842: TM-score 0.98, RMSD 1.21 Å
- 5ZC9 chain A against the predicted model P60842: TM-score 0.98, RMSD 1.22 Å
- 2G9N chain A against the predicted model P60842: TM-score 0.97, RMSD 1.11 Å
- 2G9N chain A against the predicted model P60842: TM-score 0.97, RMSD 1.11 Å
- 5ZBZ chain A against the predicted model P60842: TM-score 0.96, RMSD 1.21 Å
- 8OZ0 chain 3 against the predicted model P60842: TM-score 0.75, RMSD 4.09 Å
- 8OZ0 chain 1 against the predicted model P60842: TM-score 0.74, RMSD 4.00 Å
- 3EIQ chain A against the predicted model P60842: TM-score 0.67, RMSD 4.22 Å
Elsewhere
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