MolNFT v1 · #37693 · protein
Structure of the dead domain of human eukaryotic initiation factor 4A, EIF4A
2G9N · Eukaryotic initiation factor 4A-I: “Structure of the dead domain of human eukaryotic initiation factor 4A, EIF4A”. X-ray diffraction, 4 pockets (best druggability 0.65). MolNFT v1 #37693 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2G9N
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic initiation factor 4A-I
- EC
- 3.6.1.-
- UniProt
- P60842
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic initiation factor 4A-I (EC 3.6.1.-) | protein | 216 | 40% helix, 14% strand | P60842 |
| B | Eukaryotic initiation factor 4A-I (EC 3.6.1.-) | protein | 215 | 44% helix, 14% strand | P60842 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 335 | 0.65 | 0.80 | 44 | empty |
| 2 | 51 | 0.38 | 0.81 | 19 | empty |
| 3 | 56 | 0.35 | 0.78 | 14 | empty |
| 4 | 52 | 0.28 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 826 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 27 modified (methylation).
Compared structures
- 2G9N · Structure of the DEAD domain of Human eukaryotic initiation factor 4A, eIF4A · the same entry in another collection · chain A against A, TM-score 1.00
- P60842 · AlphaFold monomer V2.0 prediction for eukaryotic initiation factor 4A-I (P60842) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60842
- Elsewhere: RCSB PDB 2G9N · PDBe 2G9N · UniProt P60842
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