MolNFT v1 · #185322 · protein
Crystal structure of the burkholderia lethal factor 1 (BLF1) C94S inactive mutant in complex with human EIF4A - crystal form a
7PPZ: “Crystal structure of the burkholderia lethal factor 1 (BLF1) C94S inactive mutant in complex with human EIF4A…”. X-ray diffraction, 7 pockets (best druggability 0.76). MolNFT v1 #185322 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7PPZ
- Type
- protein
- Length
- 580 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Burkholderia lethal factor 1 (BLF1); Eukaryotic initiation factor 4A-I
- EC
- 3.6.4.13
- UniProt
- Q63UP7, P60842
- Pockets
- 7 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Burkholderia lethal factor 1 (BLF1) | protein | 209 | 17% helix, 44% strand | Q63UP7 |
| B | Eukaryotic initiation factor 4A-I (EC 3.6.4.13) | protein | 371 | 39% helix, 19% strand | P60842 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 870 | 0.76 | 0.80 | 82 | empty |
| 2 | 51 | 0.73 | 0.99 | 16 | empty |
| 3 | 61 | 0.51 | 0.86 | 19 | empty |
| 4 | 96 | 0.49 | 0.82 | 22 | empty |
| 5 | 134 | 0.45 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1999 Ų buried · 42 hydrogen bonds · protein-protein
Compared structures
- 7PPZ · Crystal structure of the Burkholderia Lethal Factor 1 (BLF1) C94S inactive mutant in… · the same entry in another collection · chain A against A, TM-score 1.00
- P60842 · AlphaFold monomer V2.0 prediction for eukaryotic initiation factor 4A-I (P60842) · a predicted model of the same protein · chain B against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q63UP7
- Every structure of UniProt P60842
- Elsewhere: RCSB PDB 7PPZ · PDBe 7PPZ · UniProt Q63UP7 · UniProt P60842
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