MolNFT v1 · #185323 · protein
Crystal structure of the burkholderia lethal factor 1 (BLF1) C94S inactive mutant in complex with human EIF4A - crystal form B
7PQ0: “Crystal structure of the burkholderia lethal factor 1 (BLF1) C94S inactive mutant in complex with human EIF4A…”. X-ray diffraction, 5 pockets (best druggability 0.78). MolNFT v1 #185323 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7PQ0
- Type
- protein
- Length
- 595 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Burkholderia lethal factor 1 (BLF1); Eukaryotic initiation factor 4A-I
- EC
- 3.6.4.13
- UniProt
- Q63UP7, P60842
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Burkholderia lethal factor 1 (BLF1) | protein | 210 | 16% helix, 42% strand | Q63UP7 |
| B | Eukaryotic initiation factor 4A-I (EC 3.6.4.13) | protein | 385 | 39% helix, 19% strand | P60842 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 900 | 0.78 | 0.81 | 84 | empty |
| 2 | 78 | 0.56 | 0.87 | 20 | empty |
| 3 | 232 | 0.54 | 0.77 | 35 | empty |
| 4 | 59 | 0.44 | 0.83 | 20 | empty |
| 5 | 66 | 0.30 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1992 Ų buried · 48 hydrogen bonds · protein-protein
Compared structures
- 7PQ0 · Crystal structure of the Burkholderia Lethal Factor 1 (BLF1) C94S inactive mutant in… · the same entry in another collection · chain A against A, TM-score 1.00
- P60842 · AlphaFold monomer V2.0 prediction for eukaryotic initiation factor 4A-I (P60842) · a predicted model of the same protein · chain B against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q63UP7
- Every structure of UniProt P60842
- Elsewhere: RCSB PDB 7PQ0 · PDBe 7PQ0 · UniProt Q63UP7 · UniProt P60842
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