UniProt P50579
Methionine aminopeptidase 2 (P50579)
Methionine aminopeptidase 2 (UniProt P50579), EC 3.4.11.18: 67 experimental structures and 1 predicted model on GenesisL1, 21 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P50579
- Protein
- Methionine aminopeptidase 2
- EC
- 3.4.11.18
- Experimental structures
- 67
- Predicted models
- 1
- Ligands
- 21
- Pockets
- 27 · 7 records with a druggable one
Structures
68 records of P50579 in the MolNFT archive: 67 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B59 | Complex of human methionine aminopeptidase-2 complexed with ovalicin | x-ray diffraction | A | — | — |
| 1B59 | Complex of human methionine aminopeptidase-2 complexed with ovalicin | x-ray diffraction | A | — | — |
| 1B6A | Human methionine aminopeptidase 2 complexed with tnp-470 | x-ray diffraction | A | — | — |
| 1B6A | Human methionine aminopeptidase 2 complexed with tnp-470 | x-ray diffraction | A | — | — |
| 1BN5 | Human methionine aminopeptidase 2 | x-ray diffraction | A | — | — |
| 1BN5 | Human methionine aminopeptidase 2 | x-ray diffraction | A | — | — |
| 1BOA | Human methionine aminopeptidase 2 complexed with angiogenesis inhibitor fumagillin | x-ray diffraction | A | — | — |
| 1BOA | Human methionine aminopeptidase 2 complexed with angiogenesis inhibitor fumagillin | x-ray diffraction | A | — | — |
| 1KQ0 | Human methionine aminopeptidase type II in complex with D-methionine | x-ray diffraction | A | — | — |
| 1KQ0 | Human methionine aminopeptidase type II in complex with D- methionine | x-ray diffraction | A | — | — |
| 1KQ9 | Human methionine aminopeptidase type II in complex with L-methionine | x-ray diffraction | A | — | — |
| 1KQ9 | Human methionine aminopeptidase type II in complex with L- methionine | x-ray diffraction | A | — | — |
| 1QZY | Human Methionine Aminopeptidase in complex with bengamide inhibitor LAF153 and cobalt | x-ray diffraction | A | — | — |
| 1QZY | Human methionine aminopeptidase in complex with bengamide inhibitor LAF153 and cobalt | x-ray diffraction | A | — | — |
| 1R58 | Crystal Structure of MetAP2 complexed with A357300 | x-ray diffraction | A | — | — |
| 1R58 | Crystal structure of METAP2 complexed with A357300 | x-ray diffraction | A | — | — |
| 1R5G | Crystal Structure of MetAP2 complexed with A311263 | x-ray diffraction | A | — | — |
| 1R5G | Crystal structure of METAP2 complexed with A311263 | x-ray diffraction | A | — | — |
| 1R5H | Crystal Structure of MetAP2 complexed with A320282 | x-ray diffraction | A | — | — |
| 1R5H | Crystal structure of METAP2 complexed with A320282 | x-ray diffraction | A | — | — |
| 1YW7 | h-MetAP2 complexed with A444148 | x-ray diffraction | A | — | — |
| 1YW7 | H-METAP2 complexed with A444148 | x-ray diffraction | A | — | — |
| 1YW8 | h-MetAP2 complexed with A751277 | x-ray diffraction | A | — | — |
| 1YW8 | H-METAP2 complexed with A751277 | x-ray diffraction | A | — | — |
| 1YW9 | h-MetAP2 complexed with A849519 | x-ray diffraction | A | — | — |
| 1YW9 | H-METAP2 complexed with A849519 | x-ray diffraction | A | — | — |
| 2ADU | Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor | x-ray diffraction | A | — | — |
| 2ADU | Human methionine aminopeptidase complex with 4-aryl-1,2,3-triazole inhibitor | x-ray diffraction | A | — | — |
| 2EA2 | h-MetAP2 complexed with A773812 | x-ray diffraction | A | — | — |
| 2EA2 | H-METAP2 complexed with A773812 | x-ray diffraction | A | — | — |
| 2EA4 | h-MetAP2 complexed with A797859 | x-ray diffraction | A | — | — |
| 2EA4 | H-METAP2 complexed with A797859 | x-ray diffraction | A | — | — |
| 2GA2 | h-MetAP2 complexed with A193400 | x-ray diffraction | A | — | — |
| 2GA2 | H-METAP2 complexed with A193400 | x-ray diffraction | A | — | — |
| 2OAZ | Human Methionine Aminopeptidase-2 Complexed with SB-587094 | x-ray diffraction | A | — | — |
| 2OAZ | Human methionine aminopeptidase-2 complexed with sb-587094 | x-ray diffraction | A | — | — |
| 5CLS | Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31a | x-ray diffraction | A | CO, 52T, CL | — |
| 5CLS | Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31A | x-ray diffraction | A | — | — |
| 5D6E | Structure of human methionine aminopeptidase 2 with covalent spiroepoxytriazole inhibitor (-)-31B | x-ray diffraction | A | — | — |
| 5D6F | Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31B | x-ray diffraction | A | — | — |
| 5JFR | Potent, reversible METAP2 inhibitors via fragment based drug discovery | x-ray diffraction | A | — | — |
| 5JHU | Potent, Reversible MetAP2 Inhibitors via FBDD | x-ray diffraction | A | MN, 6KO | 4 (best 0.69) |
| 5JHU | Potent, reversible METAP2 inhibitors via fbdd | x-ray diffraction | A | — | — |
| 5JI6 | Potent, Reversible MetAP2 Inhibitors via FBDD | x-ray diffraction | A | MN, SO4, 6KN | 3 (best 0.68) |
| 5JI6 | Potent, reversible METAP2 inhibitors via fbdd | x-ray diffraction | A | — | — |
| 5LYW | CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX; WITH AN INHIBITOR… | x-ray diffraction | A | 7BH, MN | — |
| 5LYW | Crystal structure of human methionine aminopeptidase-2 in complex; with an inhibitor… | x-ray diffraction | A | 7BH, MN | — |
| 5LYX | CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX; WITH AN INHIBITOR… | x-ray diffraction | A | 7BF, MN | — |
| 5LYX | Crystal structure of human methionine aminopeptidase-2 in complex; with an inhibitor… | x-ray diffraction | A | 7BF, MN | — |
| 6QED | Crystal structure of human methionine aminopeptidase-2 in complex; with an inhibitor… | x-ray diffraction | A | HZK, MN | — |
| 6QEF | Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor… | x-ray diffraction | A | HZW, MN | — |
| 6QEG | CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR… | x-ray diffraction | A | K4K, MN | — |
| 6QEG | Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor… | x-ray diffraction | A | K4K, MN | — |
| 6QEH | CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR… | x-ray diffraction | A | HZQ, MN | 4 (best 0.68) |
| 6QEH | Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor… | x-ray diffraction | A | HZQ, MN | — |
| 6QEI | Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor… | x-ray diffraction | A | HZE, MN | — |
| 6QEJ | Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor… | x-ray diffraction | A | HZT, MN | — |
| 7A12 | Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor GW557358X… | x-ray diffraction | A | PO4, QVK, MN | — |
| 7A12 | Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor GW557358X… | x-ray diffraction | A | PO4, QVK, MN | — |
| 7A13 | Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor GSK1978537A… | x-ray diffraction | A | PO4, QW5, MN | — |
8 records more on the page itself.
Ligands
- MN · Manganese (II) ion · in 23 records
- PO4 · Phosphate ion · in 8 records
- HZE · 5,6-bis(fluoranyl)-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide · in 3 records
- 7BF · 5-[[(2~{R})-1-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl) pyrrolidin-2-yl]methoxy]isoquinoline · in 2 records
- 7BH · 6-[(2~{R})-2-[(2-methylphenoxy)methyl]pyrrolidin-1-yl]-7~{H}-purine · in 2 records
- CO · Cobalt (II) ion · in 2 records
- HZQ · 5-chloranylquinolin-8-ol · in 2 records
- K4K · (3~{S})-3-oxidanyl-2-oxidanylidene-1-phenyl-~{N}-(2-thiophen-2-ylethyl)pyrrolidine-3-carboxamide · in 2 records
- QV5 · 5-chloranyl-6-fluoranyl-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide · in 2 records
- QVK · 5-chloranyl-3-phenyl-1~{H}-indole-2-carboxamide · in 2 records
- 52T · (4R,7R)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate · in 1 record
- 6KN · 4-(3-methylpyridin-4-yl)-6-(trifluoromethyl)-1H-indazole · in 1 record
- 6KO · [(2R)-1-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-2-yl]methyl 2-methoxybenzoate · in 1 record
- CL · Chloride ion · in 1 record
- HZK · (3~{S})-~{N}-[(3-chloranyl-5-fluoranyl-phenyl)methyl]-3-oxidanyl-2-oxidanylidene-1-(2-oxidanylidene-3,4-dihydro-1~{H}-quinolin-6-yl)pyrrolidine-3-carboxamide · in 1 record
- HZT · ~{N}-[(4-fluorophenyl)methyl]-~{N}-(1~{H}-1,2,4-triazol-5-ylmethyl)thiophene-2-sulfonamide · in 1 record
- HZW · (3~{S})-~{N}-[(3-chloranyl-5-fluoranyl-phenyl)methyl]-3-oxidanyl-2-oxidanylidene-1-phenyl-pyrrolidine-3-carboxamide · in 1 record
- QVB · 5-chloranyl-6-fluoranyl-3-(2-propan-2-yloxyphenyl)-1~{H}-indole-2-carboxamide · in 1 record
- QW5 · 5-chloranyl-3-(3-methoxyphenyl)-1~{H}-indole-2-carboxamide · in 1 record
- SO4 · Sulfate ion · in 1 record
- W5N · [(1~{R},2~{S},3~{S},4~{R})-2-methoxy-4-methyl-3-[(2~{R},3~{S})-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-4-oxidanyl-cyclohexyl] ~{N}-(4-azanylcyclohexyl)carbamate · in 1 record
Experiment against prediction
- 5D6E chain A against the predicted model P50579: TM-score 1.00, RMSD 0.21 Å
- 1B6A chain A against the predicted model P50579: TM-score 1.00, RMSD 0.23 Å
- 1B6A chain A against the predicted model P50579: TM-score 1.00, RMSD 0.23 Å
- 1B59 chain A against the predicted model P50579: TM-score 1.00, RMSD 0.23 Å
- 1B59 chain A against the predicted model P50579: TM-score 1.00, RMSD 0.23 Å
- 5JI6 chain A against the predicted model P50579: TM-score 1.00, RMSD 0.24 Å
- 5JI6 chain A against the predicted model P50579: TM-score 1.00, RMSD 0.24 Å
- 2ADU chain A against the predicted model P50579: TM-score 1.00, RMSD 0.23 Å
- 2ADU chain A against the predicted model P50579: TM-score 1.00, RMSD 0.23 Å
- 1R5H chain A against the predicted model P50579: TM-score 1.00, RMSD 0.25 Å
Elsewhere
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