GL1X · GenesisL1 explorer

Ligand · HZE

HZE · 5,6-bis(fluoranyl)-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide

HZE, 5,6-bis(fluoranyl)-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide (C22 H24 F2 N4 O2, 414.5 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its…

Component
HZE
Formula
C22 H24 F2 N4 O2
Class
ligand
Structures
3
PDB entries
2

Binding sites

HZE in 3 structures; the first of them:

  • 7A16 · Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor… · HZE A508 · binds PHE219, PRO220, HIS231, ASP262, LEU328, HIS331, ILE338, HIS339 and 8 more
  • 6QEI · Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor… · HZE A505 · binds PHE219, PRO220, HIS231, ASP262, LEU328, HIS331, ILE338, HIS339 and 7 more
  • 7A16 · Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor… · HZE A508 · binds PHE219, PRO220, HIS231, ASP262, LEU328, HIS331, ILE338, HIS339 and 7 more

Residues it binds most

HIS 3, LEU 3, TYR 3, GLU 3, ALA 3, ASP 3, ILE 3, MET 3, PHE 3, PRO 3 (residue and the binding sites it lines).

Found with

  • MN · Manganese (II) ion
  • PO4 · Phosphate ion
  • DMS · Dimethyl sulfoxide
  • EDO · 1,2-ethanediol
  • GOL · Glycerol

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