UniProt P49166
60S ribosomal protein L37-A (P49166)
60S ribosomal protein L37-A (UniProt P49166): 189 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 192 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49166
- Protein
- 60S ribosomal protein L37-A
- Experimental structures
- 189
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 192 · 99 records with a druggable one
Structures
190 records of P49166 in the MolNFT archive: 189 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J6X | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II) | electron microscopy | 77 | — | — |
| 3J6Y | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I) | electron microscopy | 77 | — | — |
| 3J77 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | 87 | — | — |
| 3J78 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | 87 | — | — |
| 3JCT | Cryo-em structure of eukaryotic pre-60S ribosomal subunits | electron microscopy | j | — | — |
| 4U3M | Crystal structure of Anisomycin bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U3N | Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U3U | Crystal structure of Cycloheximide bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U4N | Crystal structure of Edeine bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U4O | Crystal structure of Geneticin bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U4Q | Crystal structure of Homoharringtonine bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U4R | Crystal structure of Lactimidomycin bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U4U | Crystal structure of Lycorine bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U4Y | Crystal structure of Pactamycin bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U4Z | Crystal structure of Phyllanthoside bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U50 | Crystal structure of Verrucarin bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U51 | Crystal structure of Narciclasine bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U52 | Crystal structure of Nagilactone C bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U53 | Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U55 | Crystal structure of Cryptopleurine bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U56 | Crystal structure of Blasticidin S bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4U6F | Crystal structure of T-2 toxin bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | — | — |
| 4V4B | Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models… | electron microscopy | BY | — | — |
| 4V6I | Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces… | electron microscopy | Bl | — | — |
| 4V7F | Arx1 pre-60S particle. | electron microscopy | h | — | — |
| 4V7F | ARX1 pre-60S particle. | electron microscopy | h | — | — |
| 4V7R | Yeast 80S ribosome. | x-ray diffraction | Bd, Dd | — | — |
| 4V88 | The structure of the eukaryotic ribosome at 3.0 A resolution. | x-ray diffraction | Bj, Dj | — | — |
| 4V8T | Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1 | electron microscopy | j | — | — |
| 4V8Y | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | electron microscopy | Bj | — | — |
| 4V8Z | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | electron microscopy | Bj | — | — |
| 5DGF | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA… | x-ray diffraction | O7, o7 | ZN | 1 (best 0.87) |
| 5DGV | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA… | x-ray diffraction | O7, o7 | ZN | 3 (best 0.87) |
| 5FCI | Structure of the vacant uL3 W255C mutant 80S yeast ribosome | x-ray diffraction | O7, o7 | OHX, MG, ZN | 2 (best 0.87) |
| 5GAK | Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A | electron microscopy | l | — | 2 (best 0.88) |
| 5H4P | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1 | electron microscopy | j | — | — |
| 5I4L | Crystal structure of Amicoumacin A bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | OHX, MG, ZN | 1 (best 0.86) |
| 5JCS | Cryo-EM structure of the RIX1-REA1 pre-60S particle | electron microscopy | j | — | 2 (best 0.85) |
| 5JUO | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | OA | — | 1 (best 0.88) |
| 5JUP | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | OA | — | — |
| 5JUS | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | OA | — | — |
| 5JUT | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | OA | — | 1 (best 0.87) |
| 5JUU | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | OA | — | 1 (best 0.88) |
| 5LYB | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | O7, o7 | MG, OHX, ZN | 3 (best 0.87) |
| 5M1J | Nonstop ribosomal complex bound with Dom34 and Hbs1 | electron microscopy | j5 | MG, ZN | 1 (best 0.85) |
| 5MC6 | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | electron microscopy | AF | — | — |
| 5MEI | Crystal structure of Agelastatin A bound to the 80S ribosome | x-ray diffraction | AK, DL | OHX, MG, ZN | — |
| 5NDG | Crystal structure of geneticin (G418) bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | MG, GET, ZN | 2 (best 0.88) |
| 5NDV | Crystal structure of Paromomycin bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | PAR, MG, ZN | — |
| 5NDW | Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome | x-ray diffraction | o7, O7 | MG, 8UZ, ZN | 2 (best 0.89) |
| 5OBM | Crystal structure of Gentamicin bound to the yeast 80S ribosome | x-ray diffraction | O7, o7 | MG, LLL, ZN | 2 (best 0.88) |
| 5T62 | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | w | MG | 4 (best 0.87) |
| 5T6R | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | w | — | 2 (best 0.87) |
| 5TGA | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | O7, o7 | OHX, MG, ZN | 1 (best 0.87) |
| 5TGM | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | O7, o7 | OHX, MG, ZN | 1 (best 0.87) |
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP) | electron microscopy | n | — | 1 (best 0.83) |
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (RPF1-tap) | electron microscopy | n | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | j | ZN | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | j | ZN | — |
| 6CB1 | Yeast nucleolar pre-60S ribosomal subunit (state 3) | electron microscopy | j | ZN | 1 (best 0.82) |
130 records more on the page itself.
Ligands
- ZN · Zinc ion · in 90 records
- MG · Magnesium ion · in 50 records
- OHX · osmium (III) hexammine · in 7 records
- T1C · Tigecycline · in 2 records
- 8UZ · Tc007 · in 1 record
- GET · Geneticin · in 1 record
- K · Potassium ion · in 1 record
- LLL · (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-diamino-3-((2R, 3R,6S)-3-amino-6-(aminomethyl)-tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-methyl-4-(methylamino)-tetrahydro-2H-pyran-3,5-diol · in 1 record
- PAR · Paromomycin · in 1 record
Experiment against prediction
- 9F9S chain Mh against the predicted model P49166: TM-score 0.96, RMSD 0.65 Å
- 8P8N chain RJ against the predicted model P49166: TM-score 0.96, RMSD 0.66 Å
- 8BN3 chain O7 against the predicted model P49166: TM-score 0.96, RMSD 0.66 Å
- 7ZW0 chain Lm against the predicted model P49166: TM-score 0.96, RMSD 0.65 Å
- 8AGT chain W against the predicted model P49166: TM-score 0.96, RMSD 0.66 Å
- 8AGZ chain W against the predicted model P49166: TM-score 0.96, RMSD 0.66 Å
- 8AGW chain W against the predicted model P49166: TM-score 0.96, RMSD 0.66 Å
- 8AAF chain W against the predicted model P49166: TM-score 0.96, RMSD 0.66 Å
- 8AGU chain W against the predicted model P49166: TM-score 0.96, RMSD 0.66 Å
- 8AGV chain W against the predicted model P49166: TM-score 0.96, RMSD 0.66 Å
Elsewhere
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