UniProt P48730
Casein kinase I isoform delta (P48730)
Casein kinase I isoform delta (UniProt P48730), EC 2.7.11.1, 2.7.11.26: 68 experimental structures and 1 predicted model on GenesisL1, 24 ligands bound, 118 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P48730
- Protein
- Casein kinase I isoform delta
- EC
- 2.7.11.1, 2.7.11.26
- Experimental structures
- 68
- Predicted models
- 1
- Ligands
- 24
- Pockets
- 118 · 16 records with a druggable one
Structures
69 records of P48730 in the MolNFT archive: 68 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3UYS | Crystal structure of apo human ck1d | x-ray diffraction | A, B, C, D | — | — |
| 3UYS | Crystal structure of apo human CK1D | x-ray diffraction | A, B, C, D | — | — |
| 3UYT | crystal structure of ck1d with PF670462 from P1 crystal form | x-ray diffraction | A, B, C, D | — | — |
| 3UYT | Crystal structure of CK1D with PF670462 from P1 crystal form | x-ray diffraction | A, B, C, D | — | — |
| 3UZP | crystal structure of ck1d with PF670462 from P21 crystal form | x-ray diffraction | A, B | — | — |
| 3UZP | Crystal structure of CK1D with PF670462 from P21 crystal form | x-ray diffraction | A, B | — | — |
| 4HGT | Crystal structure of ck1d with compound 13 | x-ray diffraction | A, B | — | — |
| 4HGT | Crystal structure of CK1D with compound 13 | x-ray diffraction | A, B | — | — |
| 4HNF | Crystal structure of ck1d in complex with pf4800567 | x-ray diffraction | A, B | — | — |
| 4HNF | Crystal structure of CK1D in complex with PF4800567 | x-ray diffraction | A, B | — | — |
| 4KB8 | CK1d in complex with 1-{4-[3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}-N-METHYLMETHANA… | x-ray diffraction | A, B, C, D | — | — |
| 4KB8 | CK1D in complex with 1-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4… | x-ray diffraction | A, B, C, D | — | — |
| 4KBA | CK1d in complex with 9-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-2,3,4,5-tetrahydropyrido[2,3-f]… | x-ray diffraction | A, B, C, D | — | — |
| 4KBA | CK1D in complex with 9-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]… | x-ray diffraction | A, B, C, D | — | — |
| 4KBC | CK1d in complex with {4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}METHANOL inhibitor | x-ray diffraction | A, B | — | — |
| 4KBC | CK1D in complex with {4-[3-(4-fluorophenyl)-1H-pyrazol-4-YL]PYRIDIN-2- YL}METHANOL inhibitor | x-ray diffraction | A, B | — | — |
| 4KBK | CK1d in complex with (3S)-3-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}morpholine… | x-ray diffraction | A, B, C, D | — | — |
| 4KBK | CK1D in complex with (3S)-3-{4-[3-(4-fluorophenyl)-1-methyl-1H… | x-ray diffraction | A, B, C, D | — | — |
| 4TN6 | CK1d in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4TN6 | CK1D in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4TW9 | Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with… | x-ray diffraction | A, B | — | — |
| 4TW9 | Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1DELTA and epsilon with… | x-ray diffraction | A, B | — | — |
| 4TWC | 2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4- carboxamide derivatives as potent inhibitors of… | x-ray diffraction | A, B | — | — |
| 4TWC | 2-benzamido-N-(1H-BENZO[D]IMIDAZOL-2-YL)THIAZOLE-4- carboxamide derivatives as potent inhibitors of… | x-ray diffraction | A, B | — | — |
| 5IH4 | Human Casein Kinase 1 isoform delta apo (kinase domain) | x-ray diffraction | A | ZN, SRT, SO4 | — |
| 5IH4 | Human casein kinase 1 isoform delta apo (kinase domain) | x-ray diffraction | A | — | — |
| 5IH5 | Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A | x-ray diffraction | A | ZN, AUE, SRT, SO4 | 1 (best 0.63) |
| 5IH5 | Human casein kinase 1 isoform delta (kinase domain) in complex with epiblastin a | x-ray diffraction | A | — | — |
| 5IH6 | Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative | x-ray diffraction | A | ZN, SRT, SO4, AUG | — |
| 5IH6 | Human casein kinase 1 isoform delta (kinase domain) in complex with epiblastin a derivative | x-ray diffraction | A | — | — |
| 5MQV | Crystal structure of human Casein Kinase I delta in complex with… | x-ray diffraction | A, B, C, D, E, F | D5Q, PO4 | 16 (best 0.79) |
| 5MQV | Crystal structure of human casein kinase I delta in complex with 4-(2… | x-ray diffraction | A, B, C, D, E, F | D5Q, PO4 | — |
| 5OKT | Crystal structure of human Casein Kinase I delta in complex with IWP-2 | x-ray diffraction | A, B, C, D | 9XK, SO4 | — |
| 5OKT | Crystal structure of human casein kinase I delta in complex with iwp-2 | x-ray diffraction | A, B, C, D | 9XK, SO4 | — |
| 5W4W | Identification and Profiling of a Selective and Brain Penetrant Radioligand for In Vivo Target… | x-ray diffraction | A, B, C, D | 9WG, SO4 | — |
| 5W4W | Identification and profiling of a selective and brain penetrant radioligand for in vivo target… | x-ray diffraction | A, B, C, D | 9WG, SO4 | — |
| 6F1W | Crystal structure of human Casein Kinase I delta in complex with compound 31a | x-ray diffraction | A, B | SO4, CG5 | 4 (best 0.82) |
| 6F1W | Crystal structure of human casein kinase I delta in complex with compound 31A | x-ray diffraction | A, B | SO4, CG5 | — |
| 6F26 | Crystal structure of human casein kinase I delta in complex with compound 31B | x-ray diffraction | A, B | SO4, C9Z | — |
| 6GZM | Crystal Structure of Human CKIdelta with A86 | x-ray diffraction | A, B | LCI | — |
| 6GZM | Crystal structure of human ckidelta with A86 | x-ray diffraction | A, B | LCI | — |
| 6HMP | Crystal structure of human Casein Kinase I delta in complex with a photoswitchable… | x-ray diffraction | A, B | GEW, PO4 | — |
| 6HMP | Crystal structure of human casein kinase I delta in complex with a photoswitchable… | x-ray diffraction | A, B | GEW, PO4 | — |
| 6HMR | Crystal structure of human Casein Kinase I delta in complex with a photoswitchable… | x-ray diffraction | A, B | GE5 | — |
| 6HMR | Crystal structure of human casein kinase I delta in complex with a photoswitchable… | x-ray diffraction | A, B | GE5 | — |
| 6PXN | Human Casein Kinase 1 delta Tau mutant (R178C) | x-ray diffraction | A, B | SO4 | 5 (best 0.69) |
| 6PXN | Human casein kinase 1 delta tau mutant (R178C) | x-ray diffraction | A, B | SO4 | — |
| 6PXO | Human casein kinase 1 delta (anion-free crystallization conditions) | x-ray diffraction | A, B | — | — |
| 6PXP | Human casein kinase 1 delta site 2 mutant (K171E) | x-ray diffraction | A, B | SO4 | — |
| 6RCG | Crystal structure of casein kinase 1 delta (CK1 delta) complexed with SR3029 inhibitor | x-ray diffraction | A | K0E | — |
| 6RCH | Crystal structure of casein kinase I isoform delta (CK1 delta) complexed with SR4133 inhibitor | x-ray diffraction | A, B | SO4, NA, K0B | — |
| 6RU6 | Crystal structure of casein kinase I delta (CK1D) in complex with monophosphorylated P63 PAD1P… | x-ray diffraction | A, B | ACP, NA, SO4 | — |
| 6RU7 | Crystal structure of Casein Kinase I delta (CK1d) in complex with double phosphorylated p63 PAD2P… | x-ray diffraction | A, B | ADP, NA | 4 (best 0.76) |
| 6RU7 | Crystal structure of casein kinase I delta (CK1D) in complex with double phosphorylated P63 PAD2P… | x-ray diffraction | A, B | ADP, NA | — |
| 6RU8 | Crystal structure of Casein Kinase I delta (CK1d) in complex with triple phosphorylated p63 PAD3P… | x-ray diffraction | A, B, C, D | ADP, NA, SO4 | 12 (best 0.82) |
| 6RU8 | Crystal structure of casein kinase I delta (CK1D) in complex with triple phosphorylated P63 PAD3P… | x-ray diffraction | A, B, C, D | ADP, NA, SO4 | — |
| 7P7F | Crystal structure of phosphorylated pT220 Casein Kinase I delta (CK1d), conformation 1 | x-ray diffraction | A, B, C, D | SO4, AMP, ADN | 13 (best 0.83) |
| 7P7F | Crystal structure of phosphorylated PT220 casein kinase I delta (CK1D), conformation 1 | x-ray diffraction | A, B, C, D | SO4, AMP, ADN | — |
| 7P7G | Crystal structure of phosphorylated PT220 casein kinase I delta (CK1D), conformation 2 and 3 | x-ray diffraction | A, B | AMP | — |
| 7P7H | Crystal structure of Casein Kinase I delta (CK1d) with alphaG-in conformation | x-ray diffraction | A, B | AMP | 6 (best 0.78) |
9 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 22 records
- NA · Sodium ion · in 6 records
- AMP · Adenosine monophosphate · in 5 records
- ADP · Adenosine-5'-diphosphate · in 4 records
- PO4 · Phosphate ion · in 4 records
- SRT · S,R meso-tartaric acid · in 3 records
- ZN · Zinc ion · in 3 records
- 9WG · 4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one · in 2 records
- 9XK · ~{N}-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxidanylidene-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]ethanamide · in 2 records
- ADN · Adenosine · in 2 records
- CG5 · (9~{R},10~{R},11~{S})-~{N}-[4-[3-(4-fluorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]pyridin-2-yl]-4-(4-methoxyphenyl)-10,11-bis(oxidanyl)-1,7-diazatricyclo[7.3.0.0^{3,7}]dodeca-3,5-diene-6-carboxamide · in 2 records
- D5Q · 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide · in 2 records
- GE5 · 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-[(~{E})-phenyldiazenyl]-1,3-thiazol-5-yl]pyridin-2-yl]propanamide · in 2 records
- GEW · 3-(2,5-dimethoxyphenyl)-~{N}-[4-[5-(4-fluorophenyl)-2-[(~{E})-(4-fluorophenyl)diazenyl]-3-methyl-imidazol-4-yl]pyridin-2-yl]propanamide · in 2 records
- LCI · [4-[[4-[5-(cyclopropylmethyl)-1-methyl-pyrazol-4-yl]-5-fluoranyl-pyrimidin-2-yl]amino]cyclohexyl]azanium · in 2 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 1 record
- AUE · 6-(3-chlorophenyl)pteridine-2,4,7-triamine · in 1 record
- AUG · 6-(3-bromophenyl)pteridine-2,4,7-triamine · in 1 record
- C9Z · (9~{S},10~{S},11~{R})-~{N}-[4-[3-(4-fluorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]pyridin-2-yl]-4-(4-methoxyphenyl)-10,11-bis(oxidanyl)-1,7-diazatricyclo[7.3.0.0^{3,7}]dodeca-3,5-diene-6-carboxamide · in 1 record
- EYI · 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]-1~{H}-pyrrolo[2,3-b]pyridine · in 1 record
- EZQ · 4-[5-(4-fluorophenyl)-3-(pyridin-4-ylmethyl)imidazol-4-yl]-1~{H}-pyrrolo[2,3-b]pyridine · in 1 record
- K0B · ~{N}-[[4,5-bis(fluoranyl)-1~{H}-benzimidazol-2-yl]methyl]-2-morpholin-4-yl-9-naphthalen-2-yl-purin-6-amine · in 1 record
- K0E · ~{N}-[[6,7-bis(fluoranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(3-fluorophenyl)-2-morpholin-4-yl-purin-6-amine · in 1 record
- S93 · ~{N}5-~{tert}-butyl-2-(3-chloranyl-4-fluoranyl-phenyl)-6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazine-3,5-dicarboxamide · in 1 record
Experiment against prediction
- 8D7M chain A against the predicted model P48730: TM-score 0.99, RMSD 0.57 Å
- 6F1W chain B against the predicted model P48730: TM-score 0.99, RMSD 0.56 Å
- 4HGT chain A against the predicted model P48730: TM-score 0.99, RMSD 0.60 Å
- 4HGT chain A against the predicted model P48730: TM-score 0.99, RMSD 0.60 Å
- 8D7O chain A against the predicted model P48730: TM-score 0.99, RMSD 0.61 Å
- 8D7N chain A against the predicted model P48730: TM-score 0.99, RMSD 0.62 Å
- 4KBC chain A against the predicted model P48730: TM-score 0.99, RMSD 0.65 Å
- 4KBC chain A against the predicted model P48730: TM-score 0.99, RMSD 0.65 Å
- 4KBK chain B against the predicted model P48730: TM-score 0.99, RMSD 0.65 Å
- 4KB8 chain C against the predicted model P48730: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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