MolNFT v1 · #162547 · protein

Crystal structure of casein kinase 1 delta (CK1 delta) complexed with SR3029 inhibitor

6RCG · Casein kinase I isoform delta: “Crystal structure of casein kinase 1 delta (CK1 delta) complexed with SR3029 inhibitor”. X-ray diffraction, 1 ligand (K0E), 2 pockets (best druggability 0.65). MolNFT v1 #162547 on GenesisL1: 3D…

PDB: 6RCG
Type: protein
Length: 295 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Casein kinase I isoform delta
EC: 2.7.11.1, 2.7.11.26
UniProt: P48730
Ligands: K0E
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26)	protein	295	39% helix, 20% strand	P48730

Ligands and binding sites

K0E · ~{N}-[[6,7-bis(fluoranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(3-fluorophenyl)-2-morpholin-4-yl-purin-6-amine · ligand · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	199	0.65	0.84	27	K0E
2	173	0.46	0.76	23	empty

Compared structures

6RCG · Crystal structure of Casein kinase 1 delta (CK1 delta) complexed with SR3029 inhibitor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48730
Elsewhere: RCSB PDB 6RCG · PDBe 6RCG · UniProt P48730

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.