MolNFT v1 · #160902 · protein
Human casein kinase 1 delta site 2 mutant (K171E)
6PXP · Casein kinase I isoform delta: “Human casein kinase 1 delta site 2 mutant (K171E)”. X-ray diffraction, 1 ligand (SO4), 8 pockets (best druggability 0.65). MolNFT v1 #160902 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6PXP
- Type
- protein
- Length
- 581 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase I isoform delta
- EC
- 2.7.11.1, 2.7.11.26
- UniProt
- P48730
- Ligands
- SO4
- Pockets
- 8 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26) | protein | 288 | 38% helix, 20% strand | P48730 |
| B | Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26) | protein | 293 | 39% helix, 19% strand | P48730 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 10 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.65 | 0.82 | 61 | empty |
| 2 | 135 | 0.55 | 0.82 | 19 | empty |
| 3 | 104 | 0.55 | 0.84 | 20 | empty |
| 4 | 64 | 0.55 | 0.87 | 15 | empty |
| 5 | 74 | 0.48 | 0.82 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1446 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6PXP · Human Casein Kinase 1 delta Site 2 mutant (K171E) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48730
- Elsewhere: RCSB PDB 6PXP · PDBe 6PXP · UniProt P48730
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