MolNFT v2 · #152383 · protein
Crystal structure of human Casein Kinase I delta in complex with a photoswitchable 2-Azothiazole-based inhibitor (compound 2)
6HMR: “Crystal structure of human Casein Kinase I delta in complex with a photoswitchable 2-Azothiazole-based…”. X-ray diffraction at 1.782, 1 ligand (GE5). MolNFT v2 #152383 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6HMR
- Type
- protein
- Length
- 567 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.782
- Source
- Homo sapiens
- UniProt
- P48730
- Ligands
- GE5
Structure
x-ray diffraction · resolution 1.782 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 287 | — | P48730 |
| B | — | protein | 280 | — | P48730 |
Ligands and binding sites
- GE5 · 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-[(~{E})-phenyldiazenyl]-1,3-thiazol-5-yl]pyridin-2-yl]propanamide · ligand · 2 copies · chains A, B
- MLA · Malonic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6HMR · Crystal structure of human casein kinase I delta in complex with a photoswitchable… · the same entry in another collection · chain A against A, TM-score 1.00
- P48730 · AlphaFold monomer V2.0 prediction for casein kinase I isoform delta (P48730) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48730
- Elsewhere: RCSB PDB 6HMR · PDBe 6HMR · UniProt P48730
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