UniProt P43005
Excitatory amino acid transporter 3 (P43005)
Excitatory amino acid transporter 3 (UniProt P43005): 8 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P43005
- Protein
- Excitatory amino acid transporter 3
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 27 · 2 records with a druggable one
Structures
9 records of P43005 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6S3Q | Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with TFB-TBOA | electron microscopy | A, B, C | 7O9, Y01, PC1 | 20 (best 0.86) |
| 6S3Q | Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with tfb-tboa | electron microscopy | A, B, C | 7O9, Y01, PC1 | — |
| 6X2L | HEAAT3-ifs-na | electron microscopy | A, B, C | — | — |
| 6X2Z | HEAAT3-ofs-asp | — | — | — | |
| 6X3E | HEAAT3-asymmetric-1O2I | electron microscopy | A, B, C | NA | — |
| 6X3F | HEAAT3-ifs-apo | electron microscopy | A, B, C | CHT | — |
| 7NSG | Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with hip-B | electron microscopy | A, B, C | UR5, UR8, Y01, PC1 | — |
| 8CTD | Human excitatory amino acid transporter 3 (EAAT3) protomer with bound glutamate in an outward… | electron microscopy | A | GLU, NA, HG | 7 (best 0.69) |
| P43005 | AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 3 (P43005) | predicted | A | — | — |
Ligands
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 3 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- 7O9 · (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl) phenyl]carbonylamino]phenyl]methoxy]butanedioic acid · in 2 records
- NA · Sodium ion · in 2 records
- CHT · Choline ion · in 1 record
- GLU · Glutamic acid · in 1 record
- HG · Mercury (II) ion · in 1 record
- UR5 · (+)-3-hydroxy-4,5,6,6A-tetrahydro-3AH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid · in 1 record
- UR8 · (-)-3-hydroxy-4,5,6,6A-tetrahydro-3AH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid · in 1 record
Experiment against prediction
- 6X3E chain A against the predicted model P43005: TM-score 0.98, RMSD 1.19 Å
- 8CTD chain A against the predicted model P43005: TM-score 0.97, RMSD 1.41 Å
- 6X3F chain C against the predicted model P43005: TM-score 0.65, RMSD 4.68 Å
- 6X3F chain A against the predicted model P43005: TM-score 0.65, RMSD 4.68 Å
- 6X3F chain B against the predicted model P43005: TM-score 0.65, RMSD 4.68 Å
- 6X2L chain A against the predicted model P43005: TM-score 0.63, RMSD 5.06 Å
- 6X2L chain C against the predicted model P43005: TM-score 0.63, RMSD 5.06 Å
- 6X2L chain B against the predicted model P43005: TM-score 0.63, RMSD 5.06 Å
- 6X3E chain B against the predicted model P43005: TM-score 0.63, RMSD 5.07 Å
- 6X3E chain C against the predicted model P43005: TM-score 0.62, RMSD 5.10 Å
Elsewhere
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