MolNFT v1 · #169158 · protein

HEAAT3-ifs-na

6X2L · Excitatory amino acid transporter 3: “HEAAT3-ifs-na”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #169158 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6X2L
Type: protein
Length: 1,233 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Excitatory amino acid transporter 3
UniProt: P43005
Pockets: 20 · best druggability 0.88

Structure

electron microscopy · 1 distinct chain · 72% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Excitatory amino acid transporter 3	protein	411	72% helix, 3% strand	P43005

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1073	0.88	0.88	49	empty
2	344	0.75	0.87	43	empty
3	319	0.75	0.87	40	empty
4	343	0.75	0.86	39	empty
5	719	0.70	0.77	86	empty

Interfaces

3 interfaces between chains.

A–B · 1418 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 1396 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 1392 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6X2L · hEAAT3-IFS-Na · the same entry in another collection · chain A against A, TM-score 1.00
P43005 · AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 3 (P43005) · a predicted model of the same protein · chain A against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43005
Elsewhere: RCSB PDB 6X2L · PDBe 6X2L · UniProt P43005

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