MolNFT v1 · #169180 · protein

HEAAT3-asymmetric-1O2I

6X3E · Excitatory amino acid transporter 3: “HEAAT3-asymmetric-1O2I”. Electron microscopy, 2 ligands (ASP, NA), 18 pockets (best druggability 0.88). MolNFT v1 #169180 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6X3E
Type: protein
Length: 1,241 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Excitatory amino acid transporter 3
UniProt: P43005
Ligands: ASP, NA
Pockets: 18 · best druggability 0.88

Structure

electron microscopy · 2 distinct chains · 71% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Excitatory amino acid transporter 3	protein	419	70% helix, 4% strand	P43005
B, C	Excitatory amino acid transporter 3	protein	411	72% helix, 3% strand	P43005

Ligands and binding sites

ASP · Aspartic acid · ligand · chains A
NA · Sodium ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1048	0.88	0.88	49	empty
2	282	0.76	0.88	38	empty
3	286	0.75	0.87	42	empty
4	876	0.74	0.78	79	empty
5	722	0.70	0.77	84	empty

Interfaces

3 interfaces between chains.

A–B · 1437 Å² buried · 13 hydrogen bonds · protein-protein
A–C · 1412 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 1412 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

6X3E · hEAAT3-Asymmetric-1o2i · the same entry in another collection · chain A against A, TM-score 1.00
P43005 · AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 3 (P43005) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43005
Elsewhere: RCSB PDB 6X3E · PDBe 6X3E · UniProt P43005

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.