UniProt P42264
Glutamate receptor ionotropic, kainate 3 (P42264)
Glutamate receptor ionotropic, kainate 3 (UniProt P42264): 29 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P42264
- Protein
- Glutamate receptor ionotropic, kainate 3
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 20 · 1 record with a druggable one
Structures
30 records of P42264 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3S9E | Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate | x-ray diffraction | A, B | — | — |
| 3S9E | Crystal structure of the kainate receptor GLUK3 ligand binding domain in complex with (S)-glutamate | x-ray diffraction | A, B | — | — |
| 3U92 | Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form | x-ray diffraction | A, B | — | — |
| 3U92 | Crystal structure of the GLUK3 ligand binding domain complex with kainate and zinc: P2221 form | x-ray diffraction | A, B | — | — |
| 3U93 | Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P2221 form | x-ray diffraction | A, B | — | — |
| 3U93 | Crystal structure of the GLUK3 ligand binding domain complex with glutamate and zinc: P2221 form | x-ray diffraction | A, B | — | — |
| 3U94 | Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P21212 form | x-ray diffraction | A, B, C, D | — | — |
| 3U94 | Crystal structure of the GLUK3 ligand binding domain complex with glutamate and zinc: P21212 form | x-ray diffraction | A, B, C, D | — | — |
| 4E0W | Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with kainate | x-ray diffraction | A | — | — |
| 4E0W | Crystal structure of the kainate receptor GLUK3 ligand binding domain in complex with kainate | x-ray diffraction | A | — | — |
| 4G8N | Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist… | x-ray diffraction | A | — | — |
| 4G8N | Crystal structure of the kainate receptor GLUK3 ligand-binding domain in complex with the agonist… | x-ray diffraction | A | — | — |
| 4IGR | Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist… | x-ray diffraction | A | — | — |
| 4IGR | Crystal structure of the kainate receptor GLUK3 ligand-binding domain in complex with the agonist… | x-ray diffraction | A | — | — |
| 4MH5 | Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate | x-ray diffraction | A | — | — |
| 4MH5 | Crystal structure of the kainate receptor GLUK3 ligand binding domain in complex with (S)-glutamate | x-ray diffraction | A | — | — |
| 4NWC | Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist… | x-ray diffraction | A | — | — |
| 4NWC | Crystal structure of the GLUK3 ligand-binding domain (S1S2) in complex with the agonist… | x-ray diffraction | A | — | — |
| 4NWD | Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist… | x-ray diffraction | A | — | — |
| 4NWD | Crystal structure of the kainate receptor GLUK3 ligand-binding domain in complex with the agonist… | x-ray diffraction | A | — | — |
| 5NF6 | Structure of GLUK3 ligand-binding domain (S1S2) in complex with cip-as at 2.55 a resolution | x-ray diffraction | B, A | ZN, 8VN, CL | — |
| 5O4F | Structure of GLUK3 ligand-binding domain (S1S2) in complex with the agonist lm-12B at 2.10 a… | x-ray diffraction | B, A | 8VE, ZN, CL | — |
| 6F28 | Crystal structure of the kainate receptor GLUK3 ligand binding domain in complex with… | x-ray diffraction | A, B | ZN, CG8, CL, SO4 | — |
| 6F29 | Crystal structure of the kainate receptor GLUK3 ligand binding domain in complex with… | x-ray diffraction | A | K, CL | — |
| 6JFY | GLUK3 receptor trapped in desensitized state | electron microscopy | D, A, C, B | — | — |
| 6JFZ | GLUK3 receptor complex with UBP310 | electron microscopy | A, B, D, C | — | — |
| 6JMV | Crystal structure of the GluK3 ligand binding domain complex with SYM and zinc | x-ray diffraction | A, B | CL, ZN, NA | — |
| 6JMV | Crystal structure of the GLUK3 ligand binding domain complex with sym and zinc | x-ray diffraction | A, B | CL, ZN, NA | — |
| 8BSU | Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate… | x-ray diffraction | A, B, C, D, E, F, G, H | 2J9, ZN, CL, SO4, KAI | 20 (best 0.81) |
| P42264 | AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 3 (P42264) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 7 records
- ZN · Zinc ion · in 6 records
- NA · Sodium ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- 2J9 · 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide · in 1 record
- 8VE · (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid · in 1 record
- 8VN · (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid · in 1 record
- CG8 · (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5, 7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid · in 1 record
- K · Potassium ion · in 1 record
- KAI · 3-(carboxymethyl)-4-isopropenylproline · in 1 record
Experiment against prediction
- 8BSU chain E against the predicted model P42264: TM-score 0.99, RMSD 0.68 Å
- 8BSU chain B against the predicted model P42264: TM-score 0.99, RMSD 0.69 Å
- 8BSU chain C against the predicted model P42264: TM-score 0.99, RMSD 0.72 Å
- 8BSU chain H against the predicted model P42264: TM-score 0.98, RMSD 0.75 Å
- 5O4F chain B against the predicted model P42264: TM-score 0.98, RMSD 0.77 Å
- 6F28 chain B against the predicted model P42264: TM-score 0.98, RMSD 0.78 Å
- 8BSU chain F against the predicted model P42264: TM-score 0.98, RMSD 0.78 Å
- 8BSU chain A against the predicted model P42264: TM-score 0.98, RMSD 0.81 Å
- 8BSU chain D against the predicted model P42264: TM-score 0.98, RMSD 0.83 Å
- 8BSU chain G against the predicted model P42264: TM-score 0.98, RMSD 0.84 Å
Elsewhere
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