UniProt P39900
Macrophage metalloelastase (P39900)
Macrophage metalloelastase (UniProt P39900), EC 3.4.24.65: 167 experimental structures on GenesisL1, 25 ligands bound, 42 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P39900
- Protein
- Macrophage metalloelastase
- EC
- 3.4.24.65
- Experimental structures
- 167
- Predicted models
- 0
- Ligands
- 25
- Pockets
- 42 · 13 records with a druggable one
Structures
167 records of P39900 in the MolNFT archive: 167 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JIZ | Crystal Structure Analysis of human Macrophage Elastase MMP-12 | x-ray diffraction | A, B | — | — |
| 1JIZ | Crystal structure analysis of human macrophage elastase mmp- 12 | x-ray diffraction | A, B | — | — |
| 1JK3 | Crystal structure of human MMP-12 (Macrophage Elastase) at true atomic resolution | x-ray diffraction | A | — | — |
| 1JK3 | Crystal structure of human mmp-12 (macrophage elastase) at true atomic resolution | x-ray diffraction | A | — | — |
| 1OS2 | Ternary enzyme-product-inhibitor complexes of human MMP12 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1OS2 | Ternary enzyme-product-inhibitor complexes of human MMP12 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1OS9 | Binary enzyme-product complexes of human MMP12 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1OS9 | Binary enzyme-product complexes of human MMP12 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1RMZ | Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH at 1.3 A… | x-ray diffraction | A | — | — |
| 1RMZ | Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor nngh at 1.3 a… | x-ray diffraction | A | — | — |
| 1ROS | Crystal structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy… | x-ray diffraction | A, B | — | — |
| 1ROS | Crystal structure of mmp-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H… | x-ray diffraction | A, B | — | — |
| 1UTT | Crystal Structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy… | x-ray diffraction | A | — | — |
| 1UTT | Crystal structure of mmp-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H… | x-ray diffraction | A | — | — |
| 1UTZ | Crystal Structure of MMP-12 complexed to (2R)-3-({[4-[(pyridin-4-yl)phenyl]-thien-2-yl}carboxamido)(… | x-ray diffraction | A, B | — | — |
| 1UTZ | Crystal structure of mmp-12 complexed to (2R)-3-({[4-[(pyridin-4-yl)… | x-ray diffraction | A, B | — | — |
| 1Y93 | Crystal structure of the catalytic domain of human MMP12 complexed with acetohydroxamic acid at… | x-ray diffraction | A | — | — |
| 1Y93 | Crystal structure of the catalytic domain of human MMP12 complexed with acetohydroxamic acid at… | x-ray diffraction | A | — | — |
| 1YCM | Solution Structure of matrix metalloproteinase 12 (MMP12) in the presence of… | solution nmr | A | — | — |
| 1YCM | Solution structure of matrix metalloproteinase 12 (MMP12) in the presence of… | solution nmr | A | — | — |
| 1Z3J | Solution Structure of MMP12 in the presence of N-isobutyl-N-4-methoxyphenylsulfonyl]glycyl… | solution nmr | A | — | — |
| 1Z3J | Solution structure of MMP12 in the presence of N-isobutyl-N-4- METHOXYPHENYLSULFONYL]GLYCYL… | solution nmr | A | — | — |
| 2HU6 | Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor | x-ray diffraction | A | — | — |
| 2HU6 | Crystal structure of human mmp-12 in complex with acetohydroxamic acid and a bicyclic inhibitor | x-ray diffraction | A | — | — |
| 2JXY | Solution structure of the hemopexin-like domain of MMP12 | solution nmr | A | — | — |
| 2JXY | Solution structure of the hemopexin-like domain of MMP12 | solution nmr | A | — | — |
| 2K2G | Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12)… | solution nmr | A | — | — |
| 2K2G | Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (mmp-12)… | solution nmr | A | — | — |
| 2K9C | Paramagnetic shifts in solid-state NMR of Proteins to elicit structural information | solution nmr | A | — | — |
| 2K9C | Paramagnetic shifts in solid-state NMR of proteins to elicit structural information | solution nmr | A | — | — |
| 2KRJ | High-Resolution Solid-State NMR Structure of a 17.6 kDa Protein | solid-state nmr | A | — | — |
| 2KRJ | High-resolution solid-state NMR structure of a 17.6 kda protein | solid-state nmr | A | — | — |
| 2MLR | Membrane Bilayer complex with Matrix Metalloproteinase-12 at its Alpha-face | solution nmr | A | — | — |
| 2MLR | Membrane bilayer complex with matrix metalloproteinase-12 at its alpha-face | solution nmr | A | — | — |
| 2MLS | Membrane Bilayer complex with Matrix Metalloproteinase-12 at its Beta-face | solution nmr | A | — | — |
| 2MLS | Membrane bilayer complex with matrix metalloproteinase-12 at its beta- face | solution nmr | A | — | — |
| 2N8R | Productive complex between MMP-12 and synthetic triple-helical collagen, revealed through… | solution nmr | A | — | — |
| 2N8R | Productive complex between mmp-12 and synthetic triple-helical collagen, revealed through… | solution nmr | A | — | — |
| 2OXU | Uninhibited form of human MMP-12 | x-ray diffraction | A | — | — |
| 2OXU | Uninhibited form of human mmp-12 | x-ray diffraction | A | — | — |
| 2OXW | Human MMP-12 complexed with the peptide IAG | x-ray diffraction | A | — | — |
| 2OXW | Human mmp-12 complexed with the peptide iag | x-ray diffraction | A | — | — |
| 2OXZ | Human MMP-12 in complex with two peptides PQG and IAG | x-ray diffraction | A | — | — |
| 2OXZ | Human mmp-12 in complex with two peptides pqg and iag | x-ray diffraction | A | — | — |
| 2POJ | NMR Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (MMP-12) | solution nmr | A | — | — |
| 2POJ | NMR solution structure of the inhibitor-free state of macrophage metalloelastase (mmp-12) | solution nmr | A | — | — |
| 2W0D | Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach… | x-ray diffraction | A, B, C, D | — | — |
| 2W0D | Does a fast nuclear magnetic resonance spectroscopy- and X-ray crystallography hybrid approach… | x-ray diffraction | A, B, C, D | — | — |
| 2WO8 | MMP12 complex with a beta hydroxy carboxylic acid | x-ray diffraction | A, B, C, D | — | — |
| 2WO8 | MMP12 complex with a beta hydroxy carboxylic acid | x-ray diffraction | A, B, C, D | — | — |
| 2WO9 | MMP12 complex with a beta hydroxy carboxylic acid | x-ray diffraction | A, B, C, D | — | — |
| 2WO9 | MMP12 complex with a beta hydroxy carboxylic acid | x-ray diffraction | A, B, C, D | — | — |
| 2WOA | MMP12 complex with a beta hydroxy carboxylic acid | x-ray diffraction | A, B, C, D | — | — |
| 2WOA | MMP12 complex with a beta hydroxy carboxylic acid | x-ray diffraction | A, B, C, D | — | — |
| 2Z2D | Solution structure of human macrophage elastase (MMP-12) catalytic domain complexed with a… | solution nmr | A | — | — |
| 2Z2D | Solution structure of human macrophage elastase (mmp-12) catalytic domain complexed with a… | solution nmr | A | — | — |
| 3BA0 | Crystal structure of full-length human MMP-12 | x-ray diffraction | A | — | — |
| 3BA0 | Crystal structure of full-length human mmp-12 | x-ray diffraction | A | — | — |
| 3EHX | Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor… | x-ray diffraction | A | — | — |
| 3EHX | Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor… | x-ray diffraction | A | — | — |
107 records more on the page itself.
Ligands
- CA · Calcium ion · in 31 records
- ZN · Zinc ion · in 31 records
- HAE · Acetohydroxamic acid · in 8 records
- R47 · N-[(2S)-3-[(S)-(4-bromophenyl)(hydroxy)phosphoryl]-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}propanoyl]-L-alpha-glutamyl-L-alpha-glutamine · in 5 records
- 6PJ · Cy5.5-PEG2 · in 4 records
- 56O · N-[(2R)-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}-4-(hydroxyamino)-4-oxobutanoyl]-L-alpha-glutamyl-L-alpha-glutamine · in 2 records
- 8NT · 3-[5-[(3~{S})-1,2-dithiolan-3-yl]pentanoylamino]propane-1-sulfonic acid · in 2 records
- 8NW · 5-[(3~{S})-1,2-dithiolan-3-yl]-~{N}-(3-oxidanylpropyl) pentanamide · in 2 records
- B9N · (2~{S})-2-[2-[4-(4-methoxyphenyl) phenyl]sulfonylphenyl]pentanedioic acid · in 2 records
- B9Z · (2~{S})-2-[2-[4-(4-methoxyphenyl) phenyl]sulfanylphenyl]pentanedioic acid · in 2 records
- BR · Bromide ion · in 2 records
- NGH · N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid · in 2 records
- 2IF · ~{N}1,~{N}3-bis[4-[[(4~{R})-4-[[4-[[3,5-bis(bromanyl) phenyl]methoxy]phenyl]sulfonylamino]-5-(oxidanylamino)-5-oxidanylidene-pentyl]amino]-4-oxidanylidene-butyl]benzene-1,3-dicarboxamide · in 1 record
- 55L · (R)-4-(((S)-1-(((S)-1-amino-4-carboxy-1-oxobutan-2-yl)amino)-4-carboxy-1-oxobutan-2-yl)amino)-3-((3-(3'-chloro-[1,1'-biphenyl]-4-yl)isoxazol-5-yl)methyl)-4-oxobutanoate · in 1 record
- 67F · (2S)-2-{[2-({[(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]carbamothioyl}amino)ethyl](biphenyl-4-ylsulfonyl)amino}-3-methylbutanoic acid (non-preferred name) · in 1 record
- 67M · (2R)-2-[({1-[3-({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}oxy)propyl]-1H-1,2,3-triazol-4-yl}methyl)(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid (non-preferred name) · in 1 record
- A1H07 · ~{N}-[[(4~{R})-4-cyclopropyl-2,5-bis(oxidanylidene)imidazolidin-4-yl]methyl]-2-(3-fluorophenyl)-1,2,3-triazole-4-carboxamide · in 1 record
- BKW · 2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]ethanoic acid · in 1 record
- CL · Chloride ion · in 1 record
- H27 · (2R)-2-[{(E)-2-[({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}carbamothioyl)amino]ethenyl}(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid · in 1 record
- K0Q · ~{N}-[2-(1~{H}-indol-3-yl)ethyl]-2-(3-oxidanyl-2-oxidanylidene-pyridin-1-yl)ethanamide · in 1 record
- K8T · 2-(3-oxidanyl-2-oxidanylidene-pyridin-1-yl)-~{N}-[2-(4-phenylphenyl)ethyl]ethanamide · in 1 record
- LPW · 2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]-~{N}-oxidanyl-ethanamide · in 1 record
- V24 · N-[([1,1'-biphenyl]-4-yl)sulfonyl]-N-({1-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-1H-1,2,3-triazol-4-yl}methyl)-D-valine · in 1 record
- V28 · N-({1-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-1H-1,2,3-triazol-4-yl}methyl)-N-[([1,1'-biphenyl]-4-yl)sulfonyl]-D-valine · in 1 record
Elsewhere
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