UniProt P35609
Alpha-actinin-2 (P35609)
Alpha-actinin-2 (UniProt P35609): 29 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35609
- Protein
- Alpha-actinin-2
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 22 · 5 records with a druggable one
Structures
30 records of P35609 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H8B | EF-hands 3,4 from alpha-actinin / Z-repeat 7 from titin | solution nmr | A | — | — |
| 1H8B | Ef-hands 3,4 from alpha-actinin / Z-repeat 7 from titin | solution nmr | A | — | — |
| 1HCI | Crystal structure of the rod domain of alpha-actinin | x-ray diffraction | A, B | — | — |
| 1HCI | Crystal structure of the rod domain of alpha-actinin | x-ray diffraction | A, B | — | — |
| 1QUU | Crystal structure of two central spectrin-like repeats from alpha-actinin | x-ray diffraction | A | — | — |
| 1QUU | Crystal structure of two central spectrin-like repeats from alpha- actinin | x-ray diffraction | A | — | — |
| 4D1E | The crystal structure of human muscle alpha-actinin-2 | x-ray diffraction | A | — | — |
| 4D1E | The crystal structure of human muscle alpha-actinin-2 | x-ray diffraction | A | — | — |
| 5A36 | Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation… | x-ray diffraction | A, B | — | 2 (best 0.68) |
| 5A36 | Mutations in the calponin homology domain of alpha-actinin- 2 affect actin binding and… | x-ray diffraction | A, B | — | — |
| 5A37 | Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation… | x-ray diffraction | A, B | — | — |
| 5A37 | Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation… | x-ray diffraction | A, B | — | — |
| 5A38 | Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation… | x-ray diffraction | A, B | — | 2 (best 0.63) |
| 5A38 | Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation… | x-ray diffraction | A, B | — | — |
| 5A4B | Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation… | x-ray diffraction | A, B | — | — |
| 5A4B | Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation… | x-ray diffraction | A, B | — | — |
| 6SWT | Affimer9 co-crystalised with the CH domains of alpha actinin 2. | x-ray diffraction | A | — | 2 (best 0.40) |
| 6SWT | AFFIMER9 co-crystalised with the ch domains of alpha actinin 2. | x-ray diffraction | A | — | — |
| 6TS3 | EF-hands 3 and 4 of alpha-actinin in complex with CaMKII regulatory segment | x-ray diffraction | A, B | — | — |
| 6TS3 | Ef-hands 3 and 4 of alpha-actinin in complex with camkii regulatory segment | x-ray diffraction | A, B | — | — |
| 7A8T | Crystal structure of sarcomeric protein fatz-1 (mini-fatz-1 construct) in complex with rod domain… | x-ray diffraction | A | — | — |
| 7A8U | Crystal structure of sarcomeric protein fatz-1 (D91-fatz-1 construct) in complex with rod domain of… | x-ray diffraction | A | — | — |
| 7ANK | Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with half dimer of… | x-ray diffraction | A, B | — | 13 (best 0.74) |
| 7ANK | Crystal structure of sarcomeric protein fatz-1 (D91-fatz-1 construct) in complex with half dimer of… | x-ray diffraction | A, B | — | — |
| 7B55 | Crystal structure of camkii-actinin complex bound to mes | x-ray diffraction | A | — | — |
| 7B56 | Crystal structure of CaMKII-actinin complex bound to AMPPNP | x-ray diffraction | A | ANP | 1 (best 0.78) |
| 7B56 | Crystal structure of camkii-actinin complex bound to amppnp | x-ray diffraction | A | ANP | — |
| 7B57 | Crystal structure of CaMKII-actinin complex bound to ADP | x-ray diffraction | A | — | 2 (best 0.69) |
| 7B57 | Crystal structure of camkii-actinin complex bound to ADP | x-ray diffraction | A | — | — |
| P35609 | AlphaFold monomer V2.0 prediction for alpha-actinin-2 (P35609) | predicted | A | — | — |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
Experiment against prediction
- 5A4B chain A against the predicted model P35609: TM-score 0.99, RMSD 0.51 Å
- 5A4B chain A against the predicted model P35609: TM-score 0.99, RMSD 0.51 Å
- 5A4B chain B against the predicted model P35609: TM-score 0.99, RMSD 0.52 Å
- 5A4B chain B against the predicted model P35609: TM-score 0.99, RMSD 0.52 Å
- 5A38 chain A against the predicted model P35609: TM-score 0.99, RMSD 0.52 Å
- 5A38 chain A against the predicted model P35609: TM-score 0.99, RMSD 0.52 Å
- 5A38 chain B against the predicted model P35609: TM-score 0.99, RMSD 0.53 Å
- 5A38 chain B against the predicted model P35609: TM-score 0.99, RMSD 0.53 Å
- 5A37 chain B against the predicted model P35609: TM-score 0.99, RMSD 0.58 Å
- 5A37 chain B against the predicted model P35609: TM-score 0.99, RMSD 0.58 Å
Elsewhere
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