MolNFT v1 · #113031 · protein
Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
5A38: “Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.”. X-ray diffraction, 2 pockets (best druggability 0.63). MolNFT v1 #113031 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5A38
- Type
- protein
- Length
- 446 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-actinin-2
- UniProt
- P35609
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Alpha-actinin-2 | protein | 223 | 61% helix, 2% strand | P35609 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 489 | 0.63 | 0.76 | 54 | empty |
| 2 | 131 | 0.41 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 335 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5A38 · Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and… · the same entry in another collection · chain A against A, TM-score 1.00
- P35609 · AlphaFold monomer V2.0 prediction for alpha-actinin-2 (P35609) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35609
- Elsewhere: RCSB PDB 5A38 · PDBe 5A38 · UniProt P35609
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