MolNFT v1 · #88649 · protein

The crystal structure of human muscle alpha-actinin-2

4D1E: “The crystal structure of human muscle alpha-actinin-2”. X-ray diffraction, 5 pockets (best druggability 0.79). MolNFT v1 #88649 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4D1E
Type: protein
Length: 859 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-actinin-2
UniProt: P35609
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-actinin-2	protein	859	70% helix, 1% strand	P35609

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	885	0.79	0.81	69	empty
2	94	0.38	0.76	19	empty
3	91	0.37	0.76	17	empty
4	50	0.35	0.79	9	empty
5	50	0.34	0.78	12	empty

Modifications

Observed in the structure: 13 modified (methylation).

Compared structures

4D1E · The crystal structure of human muscle alpha-actinin-2 · the same entry in another collection · chain A against A, TM-score 1.00
P35609 · AlphaFold monomer V2.0 prediction for alpha-actinin-2 (P35609) · a predicted model of the same protein · chain A against A, TM-score 0.42

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35609
Elsewhere: RCSB PDB 4D1E · PDBe 4D1E · UniProt P35609

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