MolNFT v1 · #172642 · protein
Crystal structure of sarcomeric protein fatz-1 (D91-fatz-1 construct) in complex with rod domain of alpha-actinin-2
7A8U: “Crystal structure of sarcomeric protein fatz-1 (D91-fatz-1 construct) in complex with rod domain of…”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #172642 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7A8U
- Type
- protein
- Length
- 485 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-actinin-2; Myozenin-1
- UniProt
- P35609, Q9NP98
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-actinin-2 | protein | 474 | 80% helix, 0% strand | P35609 |
| B | Myozenin-1 | protein | 11 | 0% helix, 0% strand | Q9NP98 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.54 | 0.87 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 460 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7A8U · Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with rod… · the same entry in another collection · chain A against A, TM-score 1.00
- P35609 · AlphaFold monomer V2.0 prediction for alpha-actinin-2 (P35609) · a predicted model of the same protein · chain A against A, TM-score 0.52
- Q9NP98 · AlphaFold monomer V2.0 prediction for myozenin-1 (Q9NP98) · a predicted model of the same protein · chain B against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35609
- Every structure of UniProt Q9NP98
- Elsewhere: RCSB PDB 7A8U · PDBe 7A8U · UniProt P35609 · UniProt Q9NP98
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