UniProt P34942
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (P34942)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (UniProt P34942): 40 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 51 pockets. Binding sites, druggability and experiment…
- UniProt
- P34942
- Protein
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 51 · 23 records with a druggable one
Structures
41 records of P34942 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LC5 | Structure of mammalian respiratory complex I, CLASS2 | electron microscopy | O | — | — |
| 5LDW | Structure of mammalian respiratory Complex I, class1 | electron microscopy | O | — | — |
| 5LDW | Structure of mammalian respiratory complex I, CLASS1 | electron microscopy | O | — | — |
| 5LDX | Structure of mammalian respiratory complex I, CLASS3. | electron microscopy | O | — | — |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | O | — | 1 (best 0.87) |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | O | — | — |
| 7DGQ | Activity optimized supercomplex state1 | electron microscopy | S | PC1 | 1 (best 0.84) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | S | PC1 | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | S | PC1 | — |
| 7DKF | Activity optimized supercomplex state4 | electron microscopy | S2 | PC1 | — |
| 7QSD | Bovine complex I in the active state at 3.1 A | electron microscopy | O | 3PE, GTP, MG | 2 (best 0.81) |
| 7QSD | Bovine complex I in the active state at 3.1 a | electron microscopy | O | 3PE, GTP, MG | — |
| 7QSK | Bovine complex I in lipid nanodisc, active-Q10 | electron microscopy | O | 3PE, CDL, GTP, MG | — |
| 7QSL | Bovine complex I in lipid nanodisc, active-apo | electron microscopy | O | 3PE, CDL, GTP, MG | — |
| 7QSM | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | electron microscopy | O | 3PE, CDL, PC1, GTP, MG | 2 (best 0.85) |
| 7QSM | Bovine complex I in lipid nanodisc, deactive-ligand (composite) | electron microscopy | O | CDL, PC1, GTP, MG, 3PE | — |
| 7QSN | Bovine complex I in lipid nanodisc, deactive-apo | electron microscopy | O | 3PE, CDL, PC1, GTP, MG | — |
| 7QSO | Bovine complex I in lipid nanodisc, State 3 (Slack) | electron microscopy | O | CDL, GTP, MG | — |
| 7QSO | Bovine complex I in lipid nanodisc, state 3 (slack) | electron microscopy | O | CDL, GTP, MG | — |
| 7R41 | Bovine complex I in the presence of IM1761092, active class i (Composite map) | electron microscopy | O | 3PE, GTP, MG | 2 (best 0.81) |
| 7R43 | Bovine complex I in the presence of IM1761092, active class iii (Composite map) | electron microscopy | O | GTP, MG, 3PE | — |
| 7R44 | Bovine complex I in the presence of IM1761092, active class iv (Composite map) | electron microscopy | O | 3PE, GTP, MG | 3 (best 0.84) |
| 7R45 | Bovine complex I in the presence of IM1761092, deactive class i (Composite map) | electron microscopy | O | 3PE, GTP, MG | 3 (best 0.84) |
| 7R46 | Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) | electron microscopy | O | GTP, MG, 3PE | 2 (best 0.81) |
| 7R47 | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | electron microscopy | O | 3PE, GTP, MG | — |
| 7R48 | Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) | electron microscopy | O | 3PE, GTP, MG | 1 (best 0.83) |
| 7R4C | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | electron microscopy | O | GTP, MG, 3PE | 2 (best 0.84) |
| 7R4G | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | electron microscopy | O | CDL, 3PE, GTP, MG | — |
| 8Q0A | Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | O | 3PE, CDL, MG, DGT, PLC | 3 (best 0.83) |
| 8Q0F | Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | O | CDL, 3PE, DGT, MG | 3 (best 0.84) |
| 8Q0J | Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. | electron microscopy | O | 3PE, CDL, DGT, MG | 1 (best 0.83) |
| 8Q0M | Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | O | CDL, DGT, MG, 3PE, PLC | 2 (best 0.83) |
| 8Q1P | Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially… | electron microscopy | O | 3PE, CDL, DGT, MG | 2 (best 0.81) |
| 8Q1U | Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially… | electron microscopy | O | 3PE, CDL, PLC, DGT | 3 (best 0.84) |
| 8Q1Y | Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially… | electron microscopy | O | CDL, 3PE, DGT, MG, PLC | 2 (best 0.84) |
| 8Q25 | Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially… | electron microscopy | O | 3PE, CDL, MG, DGT, PLC | 2 (best 0.82) |
| 8Q46 | Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | O | 3PE, CDL, DGT, MG | 3 (best 0.85) |
| 8Q47 | Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. | electron microscopy | O | 3PE, CDL, DGT, MG, PLC | 3 (best 0.84) |
| 8Q49 | Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | O | 3PE, CDL, DGT, MG, PLC | 2 (best 0.85) |
| 8Q4A | Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | O | 3PE, CDL, DGT, MG, PLC | 2 (best 0.86) |
| P34942 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit… | predicted | A | — | 4 (best 0.64) |
Ligands
- MG · Magnesium ion · in 29 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 28 records
- CDL · Cardiolipin · in 20 records
- GTP · Guanosine-5'-triphosphate · in 18 records
- DGT · 2'-deoxyguanosine-5'-triphosphate · in 12 records
- PLC · Diundecyl phosphatidyl choline · in 8 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 7 records
Experiment against prediction
- 7R48 chain O against the predicted model P34942: TM-score 0.99, RMSD 0.53 Å
- 7R45 chain O against the predicted model P34942: TM-score 0.99, RMSD 0.54 Å
- 8Q49 chain O against the predicted model P34942: TM-score 0.99, RMSD 0.54 Å
- 7QSN chain O against the predicted model P34942: TM-score 0.99, RMSD 0.54 Å
- 7R46 chain O against the predicted model P34942: TM-score 0.99, RMSD 0.54 Å
- 7QSM chain O against the predicted model P34942: TM-score 0.99, RMSD 0.55 Å
- 7QSM chain O against the predicted model P34942: TM-score 0.99, RMSD 0.55 Å
- 8Q4A chain O against the predicted model P34942: TM-score 0.99, RMSD 0.55 Å
- 7R47 chain O against the predicted model P34942: TM-score 0.99, RMSD 0.56 Å
- 7R4C chain O against the predicted model P34942: TM-score 0.99, RMSD 0.57 Å
Elsewhere
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