UniProt P32455
Guanylate-binding protein 1 (P32455)
Guanylate-binding protein 1 (UniProt P32455), EC 3.6.5.-: 18 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P32455
- Protein
- Guanylate-binding protein 1
- EC
- 3.6.5.-
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 31 · 3 records with a druggable one
Structures
19 records of P32455 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DG3 | Structure of human guanylate binding protein-1 in nucleotide free form | x-ray diffraction | A | — | — |
| 1DG3 | Structure of human guanylate binding protein-1 in nucleotide free form | x-ray diffraction | A | — | — |
| 1F5N | Human guanylate binding protein-1 in complex with the GTP analogue, gmppnp. | x-ray diffraction | A | — | — |
| 1F5N | Human guanylate binding protein-1 in complex with the GTP analogue, gmppnp. | x-ray diffraction | A | — | — |
| 2B8W | Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1… | x-ray diffraction | A, B | — | — |
| 2B8W | Crystal-structure of the N-terminal large GTPase domain of human guanylate binding protein 1… | x-ray diffraction | A, B | — | — |
| 2B92 | Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1… | x-ray diffraction | A, B | — | — |
| 2B92 | Crystal-structure of the N-terminal large GTPase domain of human guanylate binding protein 1… | x-ray diffraction | A, B | — | — |
| 2BC9 | Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1… | x-ray diffraction | A | — | — |
| 2BC9 | Crystal-structure of the N-terminal large GTPase domain of human guanylate binding protein 1… | x-ray diffraction | A | — | — |
| 2D4H | Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1… | x-ray diffraction | A, B | — | — |
| 2D4H | Crystal-structure of the N-terminal large GTPase domain of human guanylate binding protein 1… | x-ray diffraction | A, B | — | — |
| 6K1Z | Crystal structure of farnesylated hGBP1 | x-ray diffraction | A | FAR | 7 (best 0.75) |
| 6K1Z | Crystal structure of farnesylated HGBP1 | x-ray diffraction | A | FAR | — |
| 6K2D | The crystal structure of GBP1 with LRR domain of IpaH9.8 | x-ray diffraction | A | — | 6 (best 0.66) |
| 6K2D | The crystal structure of GBP1 with lrr domain of IPAH9.8 | x-ray diffraction | A | — | — |
| 6LOJ | The complex structure of IPAH9.8-lrr and HGBP1 | x-ray diffraction | B | GDP | — |
| 8CQB | Cryo-EM structure of the human GBP1 dimer bound to GDP-AlF3 | electron microscopy | A, B | GDP, AF3, MG | 18 (best 0.88) |
| P32455 | AlphaFold monomer V2.0 prediction for guanylate-binding protein 1 (P32455) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1F5N chain A against the predicted model P32455: TM-score 0.99, RMSD 1.14 Å
- 1F5N chain A against the predicted model P32455: TM-score 0.99, RMSD 1.14 Å
- 1DG3 chain A against the predicted model P32455: TM-score 0.98, RMSD 1.18 Å
- 1DG3 chain A against the predicted model P32455: TM-score 0.98, RMSD 1.18 Å
- 6K1Z chain A against the predicted model P32455: TM-score 0.97, RMSD 1.60 Å
- 6K1Z chain A against the predicted model P32455: TM-score 0.97, RMSD 1.60 Å
- 6LOJ chain B against the predicted model P32455: TM-score 0.95, RMSD 2.25 Å
- 2B8W chain A against the predicted model P32455: TM-score 0.93, RMSD 1.92 Å
- 2B8W chain A against the predicted model P32455: TM-score 0.93, RMSD 1.92 Å
- 2B92 chain A against the predicted model P32455: TM-score 0.93, RMSD 1.92 Å
Elsewhere
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