UniProt P31013
Tyrosine phenol-lyase (P31013)
Tyrosine phenol-lyase (UniProt P31013), EC 4.1.99.2: 38 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P31013
- Protein
- Tyrosine phenol-lyase
- EC
- 4.1.99.2
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 24 · 3 records with a druggable one
Structures
39 records of P31013 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EZ1 | Holo tyrosine phenol-lyase from Citrobacter freundii at pH 8.0 | x-ray diffraction | A, B | — | — |
| 2EZ1 | Holo tyrosine phenol-lyase from citrobacter freundii at pH 8.0 | x-ray diffraction | A, B | — | — |
| 2EZ2 | Apo tyrosine phenol-lyase from Citrobacter freundii at pH 8.0 | x-ray diffraction | A, B | — | — |
| 2EZ2 | Apo tyrosine phenol-lyase from citrobacter freundii at pH 8.0 | x-ray diffraction | A, B | — | — |
| 2TPL | Tyrosine phenol-lyase from citrobacter intermedius complex with 3-(4'-HYDROXYPHENYL)PROPIONIC acid… | x-ray diffraction | A, B | — | — |
| 2TPL | Tyrosine phenol-lyase from citrobacter intermedius complex with 3-(4'- HYDROXYPHENYL)PROPIONIC… | x-ray diffraction | A, B | — | — |
| 2VLF | Quinonoid intermediate of Citrobacter freundii tyrosine phenol-lyase formed with alanine | x-ray diffraction | A, B | — | — |
| 2VLF | Quinonoid intermediate of citrobacter freundii tyrosine phenol-lyase formed with alanine | x-ray diffraction | A, B | — | — |
| 2VLH | Quinonoid intermediate of Citrobacter freundii tyrosine phenol-lyase formed with methionine | x-ray diffraction | A, B | — | — |
| 2VLH | Quinonoid intermediate of citrobacter freundii tyrosine phenol-lyase formed with methionine | x-ray diffraction | A, B | — | — |
| 2YCN | Y71F mutant of tyrosine phenol-lyase from Citrobacter freundii in complex with quinonoid… | x-ray diffraction | A, B | — | — |
| 2YCN | Y71F mutant of tyrosine phenol-lyase from citrobacter freundii in complex with quinonoid… | x-ray diffraction | A, B | — | — |
| 2YCP | F448H mutant of tyrosine phenol-lyase from Citrobacter freundii in complex with quinonoid… | x-ray diffraction | A, B, C, D | — | — |
| 2YCP | F448H mutant of tyrosine phenol-lyase from citrobacter freundii in complex with quinonoid… | x-ray diffraction | A, B, C, D | — | — |
| 2YCT | Tyrosine phenol-lyase from Citrobacter freundii in complex with pyridine N-oxide and the quinonoid… | x-ray diffraction | A, B | — | — |
| 2YCT | Tyrosine phenol-lyase from citrobacter freundii in complex with pyridine N-oxide and the quinonoid… | x-ray diffraction | A, B | — | — |
| 2YHK | D214A mutant of tyrosine phenol-lyase from Citrobacter freundii | x-ray diffraction | A, B | — | — |
| 2YHK | D214A mutant of tyrosine phenol-lyase from citrobacter freundii | x-ray diffraction | A, B | — | — |
| 6DUR | Citrobacter freundii tyrosine phenol-lyase complexed with L-phenylalanine | x-ray diffraction | A, B | P71, K, P70 | — |
| 6DUR | Citrobacter freundii tyrosine phenol-lyase complexed with L- phenylalanine | x-ray diffraction | A, B | P71, K, P70 | — |
| 6DVX | Citrobacter freundii tyrosine phenol-lyase F448A mutant complexed with L-phenylalanine | x-ray diffraction | A, B | K, P71, P70 | — |
| 6DXV | Citrobacter freundii tyrosine phenol-lyase F448A mutant | x-ray diffraction | A, B | K | — |
| 6DYT | Citrobacter freundii tyrosine phenol-lyase F448A mutant complexed with L-alanine | x-ray diffraction | A, B | K | — |
| 6DZ5 | Citrobacter freundii tyrosine phenol-lyase F448A mutant complexed with L-alanine | x-ray diffraction | A, B | K | — |
| 6ECG | Citrobacter freundii tyrosine phenol-lyase F448A mutant complexed with L-methionine | x-ray diffraction | A, B | K, PM9 | 8 (best 0.76) |
| 6ECG | Citrobacter freundii tyrosine phenol-lyase F448A mutant complexed with L-methionine | x-ray diffraction | A, B | K | — |
| 6MLS | Citrobacter freundii tyrosine phenol-lyase complexed with 4- hydroxypyridine and aminoacrylate from… | x-ray diffraction | A, B | K, CQG | — |
| 6MME | Citrobacter freundii tyrosine phenol-lyase complexed with 4-hydroxypyridine and aminoacrylate from… | x-ray diffraction | A, B | K, CQG | — |
| 6MME | Citrobacter freundii tyrosine phenol-lyase complexed with 4- hydroxypyridine and aminoacrylate from… | x-ray diffraction | A, B | K, CQG | — |
| 6MO3 | Citrobacter freundii tyrosine phenol-lyase complexed with 4-hydroxypyridine and aminoacrylate from… | x-ray diffraction | A, B | CQG, 0JO, K, SER | 10 (best 0.81) |
| 6MO3 | Citrobacter freundii tyrosine phenol-lyase complexed with 4- hydroxypyridine and aminoacrylate from… | x-ray diffraction | A, B | CQG, K | — |
| 6MPD | Citrobacter freundii tyrosine phenol-lyase complexed with 4- hydroxypyridine and aminoacrylate from… | x-ray diffraction | A, B | K, CQG | — |
| 6MQQ | Citrobacter freundii F448A mutant tyrosine phenol-lyase complexed with 4-hydroxypyridine and… | x-ray diffraction | A, B | CQG, K | — |
| 6NV8 | Perdeuterated tyrosine phenol-lyase from Citrobacter freundii complexed with an aminoacrylate… | x-ray diffraction | A, B | K, CQG | — |
| 6NV8 | Perdeuterated tyrosine phenol-lyase from citrobacter freundii complexed with an aminoacrylate… | x-ray diffraction | A, B | K, CQG | — |
| 7TCS | M379A mutant tyrosine phenol-lyase complexed with L-methionine | x-ray diffraction | A, B, C, D | K, PN9, PLP | — |
| 7TDL | M379A mutant tyrosine phenol-lyase complexed with 3-bromo-DL-phenylalanine | x-ray diffraction | A, B, C, D | K, OY3, CL, PLP | — |
| 7TDL | M379A mutant tyrosine phenol-lyase complexed with 3-bromo-dl- phenylalanine | x-ray diffraction | A, B, C, D | K, OY3, CL, PLP | — |
| P31013 | AlphaFold monomer V2.0 prediction for tyrosine phenol-lyase (P31013) | predicted | A | — | 6 (best 0.73) |
Ligands
- K · Potassium ion · in 20 records
- CQG · pyridin-4-ol · in 9 records
- P70 · (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy) methyl]pyridin-4-yl}methylidene)-L-phenylalanine · in 3 records
- P71 · (2E)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy) methyl]pyridin-4(1H)-ylidene}methyl]imino}-3-phenylpropanoic acid · in 3 records
- PLP · Pyridoxal-5'-phosphate · in 3 records
- CL · Chloride ion · in 2 records
- OY3 · (4Z)-4-({[(1E)-2-(3-bromophenyl)-1-carboxyethylidene]azaniumyl}methylidene)-2-methyl-5-[(phosphonooxy)methyl]-1,4-dihydropyridin-3-olate · in 2 records
- 0JO · 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid · in 1 record
- PM9 · (2E)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}-4-(methylsulfanyl)butanoic acid · in 1 record
- PN9 · (4Z)-4-({[(1E)-1-carboxy-3-(methylsulfanyl) propylidene]azaniumyl}methylidene)-2-methyl-5-[(phosphonooxy)methyl]-1,4-dihydropyridin-3-olate · in 1 record
- SER · Serine · in 1 record
Experiment against prediction
- 2YCP chain A against the predicted model P31013: TM-score 1.00, RMSD 0.18 Å
- 2YCP chain A against the predicted model P31013: TM-score 1.00, RMSD 0.18 Å
- 7TCS chain A against the predicted model P31013: TM-score 1.00, RMSD 0.20 Å
- 2VLF chain A against the predicted model P31013: TM-score 1.00, RMSD 0.23 Å
- 2VLF chain A against the predicted model P31013: TM-score 1.00, RMSD 0.23 Å
- 6MO3 chain A against the predicted model P31013: TM-score 1.00, RMSD 0.25 Å
- 2YCN chain A against the predicted model P31013: TM-score 1.00, RMSD 0.25 Å
- 2YCN chain A against the predicted model P31013: TM-score 1.00, RMSD 0.25 Å
- 2VLH chain A against the predicted model P31013: TM-score 1.00, RMSD 0.25 Å
- 2VLH chain A against the predicted model P31013: TM-score 1.00, RMSD 0.25 Å
Elsewhere
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