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Ligand · YOF

YOF · 3-fluorotyrosine

YOF, 3-fluorotyrosine (C9 H10 F N O3, 199.2 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
YOF
Formula
C9 H10 F N O3
Class
ligand
Structures
12
PDB entries
6

Binding sites

YOF in 12 structures; the first of them:

  • 5YAK · The crystal structure of human IYD Thr239 mutant with ligand 3-Fluorotyrosine (F-Tyr) · YOF A502 · binds GLU157, TYR161, MET165, TRP169, LEU173, LEU176, THR178, ASN179 and 6 more
  • 6MPD · Citrobacter freundii tyrosine phenol-lyase complexed with 4-hydroxypyridine and… · YOF B1602 · binds TYR71, MET288, PHE36, THR49, SER51, ARG100, PHE123, THR124 and 8 more
  • 6Q1B · Crystal structure of oxidized iodotyrosine deiodinase (IYD) bound to FMN and… · YOF A302 · binds ARG15, GLU68, PHE71, TYR72, LEU79, TRP82, LEU83, PHE88 and 9 more
  • 7KQS · A 1.68-A resolution 3-fluoro-L-tyrosine bound crystal structure of heme-dependent… · YOF A404 · binds TRP84, HIS88, TYR141, ARG146, MET149, PHE156, SER157, GLY158 and 5 more
  • 7KQT · A 1.84-A resolution crystal structure of heme-dependent L-tyrosine hydroxylase in complex… · YOF A402 · binds TRP84, HIS88, TYR141, ARG146, MET149, PHE156, SER157, GLY158 and 6 more
  • 7KQU · A 1.58-A resolution crystal structure of ferric-hydroperoxo intermediate of L-tyrosine… · YOF A403 · binds TRP84, HIS88, TYR141, ARG146, MET149, PHE156, SER157, GLY158 and 5 more
  • 5YAK · The crystal structure of human iyd THR239 mutant with ligand 3- fluorotyrosine (F-tyr) · YOF A502 · binds GLU157, TYR161, MET165, TRP169, LEU173, LEU176, THR178, ASN179 and 6 more
  • 6MPD · Citrobacter freundii tyrosine phenol-lyase complexed with 4- hydroxypyridine and… · YOF B1602 · binds TYR71, MET288, PHE36, THR49, SER51, ARG100, PHE123, THR124 and 8 more
  • 6Q1B · Crystal structure of oxidized iodotyrosine deiodinase (iyd) bound to FMN and… · YOF A302 · binds ARG15, GLU68, PHE71, TYR72, LEU79, TRP82, LEU83, PHE88 and 9 more
  • 7KQS · A 1.68-a resolution 3-fluoro-L-tyrosine bound crystal structure of heme-dependent… · YOF A404 · binds TRP84, HIS88, TYR141, ARG146, MET149, PHE156, SER157, GLY158 and 5 more
  • 7KQT · A 1.84-a resolution crystal structure of heme-dependent L-tyrosine hydroxylase in complex… · YOF A402 · binds TRP84, HIS88, TYR141, ARG146, MET149, PHE156, SER157, GLY158 and 6 more
  • 7KQU · A 1.58-a resolution crystal structure of ferric-hydroperoxo intermediate of L-tyrosine… · YOF A403 · binds TRP84, HIS88, TYR141, ARG146, MET149, PHE156, SER157, GLY158 and 5 more

Residues it binds most

TYR 30, LEU 28, SER 28, PHE 18, ARG 24, MET 30, GLY 28, TRP 28, THR 18, ALA 12 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe
  • TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol
  • FMN · Flavin mononucleotide
  • BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol
  • 0JO · 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid
  • CQG · pyridin-4-ol
  • PEO · Hydrogen peroxide
  • K · Potassium ion
  • CL · Chloride ion
  • CYN · Cyanide ion
  • P33 · 3,6,9,12,15,18-hexaoxaicosane-1,20-diol

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