UniProt P30291

Wee1-like protein kinase (P30291)

Wee1-like protein kinase (UniProt P30291), EC 2.7.10.2: 45 experimental structures on GenesisL1, 17 ligands bound, 36 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt: P30291
Protein: Wee1-like protein kinase
EC: 2.7.10.2
Experimental structures: 45
Predicted models: 0
Ligands: 17
Pockets: 36 · 10 records with a druggable one

Structures

45 records of P30291 in the MolNFT archive: 45 experimental, 0 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1X8B	Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824	x-ray diffraction	A	—	—
1X8B	Structure of human WEE1A kinase: kinase domain complexed with inhibitor PD0407824	x-ray diffraction	A	—	—
2IN6	Wee1 kinase complex with inhibitor PD311839	x-ray diffraction	A	—	—
2IN6	WEE1 kinase complex with inhibitor PD311839	x-ray diffraction	A	—	—
2IO6	Wee1 kinase complexed with inhibitor PD330961	x-ray diffraction	A	—	—
2IO6	WEE1 kinase complexed with inhibitor PD330961	x-ray diffraction	A	—	—
2Z2W	Human Wee1 kinase complexed with inhibitor PF0335770	x-ray diffraction	A	—	—
2Z2W	Human WEE1 kinase complexed with inhibitor PF0335770	x-ray diffraction	A	—	—
3BI6	Wee1 kinase complex with inhibitor PD352396	x-ray diffraction	A	—	—
3BI6	WEE1 kinase complex with inhibitor PD352396	x-ray diffraction	A	—	—
3BIZ	Wee1 kinase complex with inhibitor PD331618	x-ray diffraction	A	—	—
3BIZ	WEE1 kinase complex with inhibitor PD331618	x-ray diffraction	A	—	—
3CQE	Wee1 kinase complex with inhibitor PD074291	x-ray diffraction	A	—	—
3CQE	WEE1 kinase complex with inhibitor PD074291	x-ray diffraction	A	—	—
3CR0	Wee1 kinase complex with inhibitor PD259_809	x-ray diffraction	A	—	—
3CR0	WEE1 kinase complex with inhibitor PD259_809	x-ray diffraction	A	—	—
5V5Y	Crystal structure of human WEE1 kinase domain in complex with MK1775	x-ray diffraction	A	8X7	—
5V5Y	Crystal structure of human WEE1 kinase domain in complex with MK1775	x-ray diffraction	A	8X7	—
5VC3	Crystal structure of human WEE1 kinase domain in complex with bosutinib	x-ray diffraction	A	DB8, CL	3 (best 0.70)
5VC3	Crystal structure of human WEE1 kinase domain in complex with bosutinib	x-ray diffraction	A	DB8, CL	—
5VC4	Crystal structure of HUMAN WEE1 KINASE domain in complex with Bosutinib-isomer	x-ray diffraction	A	XZN, PO4	5 (best 0.70)
5VC4	Crystal structure of human WEE1 kinase domain in complex with bosutinib-isomer	x-ray diffraction	A	XZN, PO4	—
5VC5	Crystal structure of human WEE1 kinase domain in complex with PD-166285	x-ray diffraction	A	96M, CL	—
5VC5	Crystal structure of human WEE1 kinase domain in complex with pd- 166285	x-ray diffraction	A	96M, CL	—
5VC6	crystal structure of human WEE1 kinase domain in complex with PHA-848125	x-ray diffraction	A	P48	4 (best 0.69)
5VC6	Crystal structure of human WEE1 kinase domain in complex with pha- 848125	x-ray diffraction	A	P48	—
5VD2	crystal structure of human WEE1 kinase domain in complex with PF-03814735	x-ray diffraction	A	34W, PO4, CL	3 (best 0.67)
5VD2	Crystal structure of human WEE1 kinase domain in complex with pf- 03814735	x-ray diffraction	A	34W, PO4, CL	—
5VD4	CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-016, a MK1775 analougue	x-ray diffraction	A	99J, PO4, CL	—
5VD4	Crystal structure of human WEE1 kinase domain in complex with rac-IV- 016, a MK1775 analougue	x-ray diffraction	A	99J, PO4, CL	—
5VD5	CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-050, a MK1775 analougue	x-ray diffraction	A	99M, CL	3 (best 0.72)
5VD5	Crystal structure of human WEE1 kinase domain in complex with rac-IV- 050, a MK1775 analougue	x-ray diffraction	A	99M, CL	—
5VD7	CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-098, a MK1775 analogue	x-ray diffraction	A	99V, CL	4 (best 0.69)
5VD7	Crystal structure of human WEE1 kinase domain in complex with rac-IV- 098, a MK1775 analogue	x-ray diffraction	A	99V, CL	—
5VD8	Crystal structure of human WEE1 kinase domain in complex with RAC-IV-099, a MK1775 analogue	x-ray diffraction	A	98M, CL	—
5VD8	Crystal structure of human WEE1 kinase domain in complex with rac-IV- 099, a MK1775 analogue	x-ray diffraction	A	98M, CL	—
5VD9	Crystal structure of human WEE1 kinase domain in complex with RAC-IV-097, a MK1775 analogue	x-ray diffraction	A	98G, CL	—
5VD9	Crystal structure of human WEE1 kinase domain in complex with rac-IV- 097, a MK1775 analogue	x-ray diffraction	A	98G, CL	—
5VDA	Crystal structure of human WEE1 kinase domain in complex with RAC-IV-101, a MK1775 analogue	x-ray diffraction	A	98D, CL	4 (best 0.65)
5VDA	Crystal structure of human WEE1 kinase domain in complex with rac-IV- 101, a MK1775 analogue	x-ray diffraction	A	98D, CL	—
7N3U	Crystal structure of human WEE1 kinase domain in complex with ZN-c3	x-ray diffraction	A	05J	2 (best 0.69)
7N3U	Crystal structure of human WEE1 kinase domain in complex with zn-C3	x-ray diffraction	A	05J	—
8BJU	HUMAN WEE1 KINASE IN COMPLEX WITH INHIBITOR 1-[6-(1-Hydroxy-1-methyl-ethyl)-pyridin-2-yl]-2-(2-metho…	x-ray diffraction	A	QT9	3 (best 0.68)
8WDK	The complex structure of Cul2-VCB-Protac-Wee1	electron microscopy	W	W6U	5 (best 0.71)
P30291	AlphaFold monomer V2.0 prediction for WEE1-like protein kinase (P30291)	—		—	—

Ligands

CL · Chloride ion · in 18 records
PO4 · Phosphate ion · in 6 records
05J · 1-[(7R)-7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one · in 2 records
34W · N-{2-[(1S,4R)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide · in 2 records
8X7 · 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one · in 2 records
96M · 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino) ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one · in 2 records
98D · 1-{6-[(1S)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one · in 2 records
98G · 1-{6-[(1R)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one · in 2 records
98M · 6-{[3-chloro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one · in 2 records
99J · 6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1-{6-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]pyridin-2-yl}-1,2-dihydro-3H-pyrazolo[3, 4-d]pyrimidin-3-one · in 2 records
99M · 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(morpholin-4-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one · in 2 records
99V · 6-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one · in 2 records
DB8 · 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile · in 2 records
P48 · N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl) phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide · in 2 records
XZN · 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile · in 2 records
QT9 · 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one · in 1 record
W6U · (2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[4-[4-[4-[[3-oxidanylidene-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]-2-prop-2-enyl-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]piperazin-1-yl]butoxy]propanoylamino]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide · in 1 record

Elsewhere

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