UniProt P29317
Ephrin type-A receptor 2 (P29317)
Ephrin type-A receptor 2 (UniProt P29317), EC 2.7.10.1: 142 experimental structures and 1 predicted model on GenesisL1, 58 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P29317
- Protein
- Ephrin type-A receptor 2
- EC
- 2.7.10.1
- Experimental structures
- 142
- Predicted models
- 1
- Ligands
- 58
- Pockets
- 52 · 16 records with a druggable one
Structures
143 records of P29317 in the MolNFT archive: 142 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MQB | Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase | x-ray diffraction | A, B | — | — |
| 1MQB | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase | x-ray diffraction | A, B | — | — |
| 2E8N | Solution structure of the C-terminal SAM-domain of EphaA2: Ephrin type-A receptor 2 precursor (EC… | solution nmr | A | — | — |
| 2E8N | Solution structure of the C-terminal SAM-domain of EPHAA2: ephrin type-a receptor 2 precursor (ec… | solution nmr | A | — | — |
| 2K9Y | EphA2 dimeric structure in the lipidic bicelle at pH 5.0 | solution nmr | A, B | — | — |
| 2K9Y | EPHA2 dimeric structure in the lipidic bicelle at pH 5.0 | solution nmr | A, B | — | — |
| 2KSO | EphA2:SHIP2 SAM:SAM complex | solution nmr | A | — | — |
| 2KSO | EPHA2:SHIP2 SAM:SAM complex | solution nmr | A | — | — |
| 2X10 | Crystal structure of the complete EphA2 ectodomain | x-ray diffraction | A | — | — |
| 2X10 | Crystal structure of the complete EPHA2 ectodomain | x-ray diffraction | A | — | — |
| 2X11 | Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain | x-ray diffraction | A | — | — |
| 2X11 | Crystal structure of the complete EPHA2 ectodomain in complex with ephrin A5 receptor binding domain | x-ray diffraction | A | — | — |
| 3C8X | Crystal structure of the ligand binding domain of human Ephrin A2 (Epha2) receptor protein kinase | x-ray diffraction | A | — | — |
| 3C8X | Crystal structure of the ligand binding domain of human ephrin A2 (EPHA2) receptor protein kinase | x-ray diffraction | A | — | — |
| 3CZU | Crystal structure of the human ephrin A2- ephrin A1 complex | x-ray diffraction | A | — | — |
| 3CZU | Crystal structure of the human ephrin A2- ephrin A1 complex | x-ray diffraction | A | — | — |
| 3HEI | Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain… | x-ray diffraction | A, C, E, G, I, K, M, O | — | — |
| 3HEI | Ligand recognition by a-class eph receptors: crystal structures of the EPHA2 ligand-binding domain… | x-ray diffraction | A, C, E, G, I, K, M, O | — | — |
| 3HPN | Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HPN | Ligand recognition by a-class eph receptors: crystal structures of the EPHA2 ligand-binding domain… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3KKA | Co-crystal structure of the sam domains of EPHA1 AND EPHA2 | x-ray diffraction | C, D, E | — | — |
| 3KKA | Co-crystal structure of the SAM domains of EPHA1 and EPHA2 | x-ray diffraction | C, D, E | — | — |
| 3MBW | Crystal structure of the human ephrin A2 LBD and CRD domains in complex with ephrin A1 | x-ray diffraction | A | — | — |
| 3MBW | Crystal structure of the human ephrin A2 lbd and crd domains in complex with ephrin A1 | x-ray diffraction | A | — | — |
| 3MX0 | Crystal Structure of EphA2 ectodomain in complex with ephrin-A5 | x-ray diffraction | A, C | — | — |
| 3MX0 | Crystal structure of EPHA2 ectodomain in complex with ephrin-A5 | x-ray diffraction | A, C | — | — |
| 3SKJ | Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody | x-ray diffraction | E, F | — | — |
| 3SKJ | Structural and functional characterization of an agonistic anti-human EPHA2 monoclonal antibody | x-ray diffraction | E, F | — | — |
| 4P2K | Structure of Ephrin type-A receptor 2 | x-ray diffraction | A | — | — |
| 4P2K | Structure of ephrin type-a receptor 2 | x-ray diffraction | A | — | — |
| 4PDO | Structure of Ephrin type-A receptor 2 | x-ray diffraction | A, B | — | — |
| 4PDO | Structure of ephrin type-a receptor 2 | x-ray diffraction | A, B | — | — |
| 4TRL | Structure of Ephrin type-A receptor 2 | x-ray diffraction | A | — | — |
| 4TRL | Structure of ephrin type-a receptor 2 | x-ray diffraction | A | — | — |
| 5EK7 | Structure of the autoinhibited Epha2 JMS-KD | x-ray diffraction | A, B | — | — |
| 5EK7 | Structure of the autoinhibited EPHA2 jms-kd | x-ray diffraction | A, B | — | — |
| 5I9U | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase | x-ray diffraction | A | — | — |
| 5I9V | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with AGS | x-ray diffraction | A | AGS | 2 (best 0.66) |
| 5I9V | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with ags | x-ray diffraction | A | — | — |
| 5I9W | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with ANP | x-ray diffraction | A | ANP | 2 (best 0.61) |
| 5I9W | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with anp | x-ray diffraction | A | — | — |
| 5I9X | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with bosutinib (SKI-606) | x-ray diffraction | A | DB8 | — |
| 5I9X | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with bosutinib (ski-606) | x-ray diffraction | A | — | — |
| 5I9Y | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with dasatinib | x-ray diffraction | A | 1N1 | — |
| 5I9Y | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with dasatinib | x-ray diffraction | A | — | — |
| 5I9Z | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with danusertib (PHA739358) | x-ray diffraction | A | 627 | — |
| 5I9Z | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with danusertib (PHA739358) | x-ray diffraction | A | — | — |
| 5IA0 | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237) | x-ray diffraction | A, B, C | A5B | — |
| 5IA0 | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with alisertib (MLN8237) | x-ray diffraction | A, B, C | — | — |
| 5IA1 | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with MLN8054 | x-ray diffraction | A | ZZL | — |
| 5IA1 | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with MLN8054 | x-ray diffraction | A | — | — |
| 5IA2 | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with compound 66 | x-ray diffraction | A | — | — |
| 5IA3 | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with PD173955 | x-ray diffraction | A | P17 | — |
| 5IA3 | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with PD173955 | x-ray diffraction | A | — | — |
| 5IA4 | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with foretinib (XL880) | x-ray diffraction | A | — | — |
| 5IA5 | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with golvatinib (E7050) | x-ray diffraction | A | GV0 | — |
| 5IA5 | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with golvatinib (E7050) | x-ray diffraction | A | — | — |
| 5NJZ | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1g | x-ray diffraction | A | 8ZH | — |
| 5NJZ | Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with compound 1G | x-ray diffraction | A | 8ZH | — |
| 5NK0 | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1j | x-ray diffraction | A | 91E | — |
83 records more on the page itself.
Ligands
- MG · Magnesium ion · in 4 records
- NH2 · Amino group · in 4 records
- 8ZZ · ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{R}, 4~{R})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide · in 3 records
- ACE · Acetyl group · in 3 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 3 records
- BTN · Biotin · in 3 records
- 29N · 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one · in 2 records
- 8ZH · ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide · in 2 records
- 8ZQ · 2-[[3-(2-aminophenyl)-5-(piperidin-4-ylcarbamoyl) phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide · in 2 records
- 8ZT · ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[(3,5-dimorpholin-4-ylphenyl)amino]-1,3-thiazole-5-carboxamide · in 2 records
- 8ZW · ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]-1,3-thiazole-5-carboxamide · in 2 records
- 90N · 2-[[3-[(4-azanyl-6-methyl-1,3,5-triazin-2-yl) carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide · in 2 records
- 90T · (3~{S})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl) carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidine-3-carboxylic acid · in 2 records
- 90W · ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(4-oxidanylcyclohexyl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide · in 2 records
- 90Z · ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(2,2,6,6-tetramethyl-1-oxidanyl-piperidin-4-yl) carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide · in 2 records
- 912 · (2~{Z})-~{N}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1, 3-thiazolidine-5-carboxamide · in 2 records
- 91E · 2-[[3-[(3-azanyl-2,2-dimethyl-propyl) carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide · in 2 records
- 92Q · ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{S})-pyrrolidin-3-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide · in 2 records
- CL · Chloride ion · in 2 records
- CS · Cesium ion · in 2 records
- DXK · 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine · in 2 records
- G02 · 4-methyl-3-[(1-methyl-6-pyrazin-2-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl) phenyl]benzamide · in 2 records
- G0E · 4-methyl-3-[(1-methyl-6-pyrimidin-5-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl) phenyl]benzamide · in 2 records
- G0K · 4-methyl-3-[(2-pyridin-3-ylpyrido[2,3-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide · in 2 records
- G0Q · ~{N}-(3-chlorophenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide · in 2 records
- HNZ · 3-[(4-imidazol-1-yl-6-piperazin-1-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl) phenyl]benzamide · in 2 records
- HO8 · 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl) phenyl]benzamide · in 2 records
- HOT · 3-[[4-imidazol-1-yl-6-(4-oxidanylpiperidin-1-yl)-1,3,5-triazin-2-yl]amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide · in 2 records
- NA · Sodium ion · in 2 records
- 1N1 · N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide · in 1 record
Experiment against prediction
- 3HEI chain M against the predicted model P29317: TM-score 0.99, RMSD 0.48 Å
- 3HEI chain M against the predicted model P29317: TM-score 0.99, RMSD 0.48 Å
- 3HEI chain A against the predicted model P29317: TM-score 0.99, RMSD 0.47 Å
- 3HEI chain A against the predicted model P29317: TM-score 0.99, RMSD 0.47 Å
- 3HEI chain O against the predicted model P29317: TM-score 0.99, RMSD 0.49 Å
- 3HEI chain O against the predicted model P29317: TM-score 0.99, RMSD 0.49 Å
- 3HEI chain C against the predicted model P29317: TM-score 0.99, RMSD 0.50 Å
- 3HEI chain C against the predicted model P29317: TM-score 0.99, RMSD 0.50 Å
- 3HEI chain G against the predicted model P29317: TM-score 0.99, RMSD 0.52 Å
- 3HEI chain G against the predicted model P29317: TM-score 0.99, RMSD 0.52 Å
Elsewhere
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