Ligand · 88Z
88Z · N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide
88Z, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (C34 H34 F2 N4 O6, 632.7 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB…
- Component
- 88Z
- Formula
- C34 H34 F2 N4 O6
- Class
- ligand
- Structures
- 4
- PDB entries
- 3
Binding sites
88Z in 4 structures; the first of them:
- 6SD9 · Crystal structure of wild-type cMET bound by foretinib · 88Z A1402 · binds ILE1084, VAL1092, ALA1108, LYS1110, GLU1127, GLY1128, MET1131, PHE1134 and 17 more
- 6I2Y · Human STK10 bound to foretinib · 88Z A2000 · binds LEU42, VAL50, ALA63, LYS65, LEU85, ILE93, VAL94, ILE108 and 13 more
- 6SD9 · Crystal structure of wild-type cmet bound by foretinib · 88Z A1402 · binds ILE1084, VAL1092, ALA1108, LYS1110, GLU1127, GLY1128, MET1131, PHE1134 and 16 more
- 6SDC · Crystal structure of D1228V cmet bound by foretinib · 88Z A1401 · binds ILE1084, VAL1092, ALA1108, LYS1110, GLU1127, MET1131, PHE1134, VAL1139 and 15 more
Residues it binds most
LEU 5, VAL 5, PHE 5, ALA 5, ILE 5, MET 3, GLY 5, LYS 5, ASP 5, GLU 5 (residue and the binding sites it lines).
Found with
- CL · Chloride ion
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