UniProt P22223
Cadherin-3 (P22223)
Cadherin-3 (UniProt P22223): 33 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22223
- Protein
- Cadherin-3
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 21 · 4 records with a druggable one
Structures
34 records of P22223 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4OY9 | Crystal structure of human P-Cadherin EC1-EC2 in closed conformation | x-ray diffraction | A | — | — |
| 4OY9 | Crystal structure of human P-cadherin EC1-EC2 in closed conformation | x-ray diffraction | A | — | — |
| 4ZML | Crystal structure of human P-cadherin (ss-dimer) | x-ray diffraction | A | — | — |
| 4ZMN | Crystal structure of human P-cadherin (ss-dimer long) | x-ray diffraction | A | CA | 1 (best 0.41) |
| 4ZMN | Crystal structure of human P-cadherin (ss-dimer long) | x-ray diffraction | A | — | — |
| 4ZMO | Crystal structure of human P-cadherin (ss-dimer K14E) | x-ray diffraction | A | — | — |
| 4ZMO | Crystal structure of human P-cadherin (ss-dimer K14E) | x-ray diffraction | A | — | — |
| 4ZMP | Crystal structure of human P-cadherin (ss-dimer Q101L) | x-ray diffraction | A | CA | 1 (best 0.41) |
| 4ZMP | Crystal structure of human P-cadherin (ss-dimer Q101L) | x-ray diffraction | A | — | — |
| 4ZMQ | Crystal structure of human P-cadherin (ss-X-dimer) | x-ray diffraction | A, B | — | — |
| 4ZMQ | Crystal structure of human P-cadherin (ss-X-dimer) | x-ray diffraction | A, B | — | — |
| 4ZMT | Crystal structure of human P-cadherin (ss-X-dimer-long) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4ZMT | Crystal structure of human P-cadherin (ss-X-dimer-long) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4ZMV | Crystal structure of human P-cadherin (ss-X-dimer pocket I) | x-ray diffraction | A, B | — | — |
| 4ZMV | Crystal structure of human P-cadherin (ss-X-dimer pocket I) | x-ray diffraction | A, B | — | — |
| 4ZMW | Crystal structure of human P-cadherin (enc-X-dimer) | x-ray diffraction | A, B | CA, SO4, NI | 3 (best 0.70) |
| 4ZMW | Crystal structure of human P-cadherin (enc-X-dimer) | x-ray diffraction | A, B | — | — |
| 4ZMX | Crystal structure of human P-cadherin (int-X-dimer) | x-ray diffraction | A, B | — | — |
| 4ZMX | Crystal structure of human P-cadherin (int-X-dimer) | x-ray diffraction | A, B | — | — |
| 4ZMY | Crystal structure of human P-cadherin (monomer 1) | x-ray diffraction | A | — | — |
| 4ZMY | Crystal structure of human P-cadherin (monomer 1) | x-ray diffraction | A | — | — |
| 4ZMZ | Crystal structure of human P-cadherin (monomer 2) | x-ray diffraction | A | — | — |
| 4ZMZ | Crystal structure of human P-cadherin (monomer 2) | x-ray diffraction | A | — | — |
| 5JYL | Human P-cadherin MEC1 with scFv TSP7 bound | x-ray diffraction | A, C | — | 3 (best 0.75) |
| 5JYL | Human P-cadherin MEC1 with scfv TSP7 bound | x-ray diffraction | A, C | — | — |
| 5JYM | Human P-cadherin EC12 with scFv TSP11 bound | x-ray diffraction | A, C | CA | 6 (best 0.60) |
| 5JYM | Human P-cadherin EC12 with scfv TSP11 bound | x-ray diffraction | A, C | — | — |
| 6ZTB | Crystal Structure of human P-Cadherin EC1_EC2 | x-ray diffraction | I | CA, NA | — |
| 6ZTB | Crystal structure of human P-cadherin EC1_EC2 | x-ray diffraction | I | CA, NA | — |
| 6ZTR | Crystal Structure of the anti-human P-Cadherin Fab CQY684 in complex with human P-Cadherin(108-324) | x-ray diffraction | I, J | CA | 7 (best 0.76) |
| 6ZTR | Crystal structure of the anti-human P-cadherin Fab CQY684 in complex with human P-CADHERIN(108-324) | x-ray diffraction | I, J | CA | — |
| 7CME | Crystal structure of human P-cadherin MEC12 (X dimer) in complex with… | x-ray diffraction | A, B | G60, CA | — |
| 7CMF | Crystal structure of human P-cadherin REC12 (monomer) in complex with… | x-ray diffraction | A | CA, G60 | — |
| P22223 | AlphaFold monomer V2.0 prediction for cadherin-3 (P22223) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5JYM chain A against the predicted model P22223: TM-score 0.98, RMSD 0.83 Å
- 5JYM chain A against the predicted model P22223: TM-score 0.98, RMSD 0.83 Å
- 7CME chain A against the predicted model P22223: TM-score 0.97, RMSD 1.24 Å
- 7CME chain B against the predicted model P22223: TM-score 0.97, RMSD 1.32 Å
- 6ZTR chain J against the predicted model P22223: TM-score 0.97, RMSD 1.08 Å
- 6ZTR chain J against the predicted model P22223: TM-score 0.97, RMSD 1.08 Å
- 4ZMT chain E against the predicted model P22223: TM-score 0.96, RMSD 1.21 Å
- 4ZMT chain E against the predicted model P22223: TM-score 0.96, RMSD 1.21 Å
- 4ZMV chain A against the predicted model P22223: TM-score 0.96, RMSD 1.23 Å
- 4ZMV chain A against the predicted model P22223: TM-score 0.96, RMSD 1.23 Å
Elsewhere
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